TMED9 - transmembrane p24 trafficking protein 9 Gene

Homo sapiens

Also known as p25; GMP25; p24a2; HSGP25L2G; p24alpha2

Gene ID: 54732 | Gene type: protein coding

About TMED9

This gene has 6 transcripts (splice variants), 207 orthologues and 8 paralogues. Ubiquitous expression in placenta (RPKM 102.0), colon (RPKM 69.9) and 25 other tissues.

Summary

This gene is a member of a family of genes encoding transport proteins located in the endoplasmic reticulum and the Golgi. A similar gene in mouse is the target of MicroRNA miR-296, which is part of an imprinted cluster. [provided by RefSeq, Jul 2016]

TMED9 Products(1)

mRNA	Protein	Name
NM_017510.6	NP_059980.2	transmembrane emp24 domain-containing protein 9 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16595549	GOA
enables syntaxin binding	IPI IPI: Inferred from physical interaction	21545355	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in COPI coating of Golgi vesicle	IMP IMP: Inferred from mutant phenotype	18287528	GOA
involved in Golgi organization	IMP IMP: Inferred from mutant phenotype	18287528	GOA
NOT involved in early endosome to Golgi transport	IMP IMP: Inferred from mutant phenotype	18287528	GOA
involved in positive regulation of organelle organization	IMP IMP: Inferred from mutant phenotype	18287528	GOA
NOT involved in protein exit from endoplasmic reticulum	IMP IMP: Inferred from mutant phenotype	18287528	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	12237308	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	12237308	GOA
located in endoplasmic reticulum-Golgi intermediate compartment	IDA IDA: Inferred from direct assay	12237308	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMED9 Protein Structure

EMP24_GP25L

0
100
200
235 a.a.

Protein Preferred Names

Protein Names

transmembrane emp24 domain-containing protein 9

glycoprotein 25L2

TMED9 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TMED9	Q9BVK6	TMEM60	Homo sapiens	Q9H2L4	Validated Y2H	32296183
Intra	TMED9	Q9BVK6	TMEM60	Homo sapiens	Q9H2L4	Y2H Array	32296183
Intra	TMED9	Q9BVK6	PTPN2	Homo sapiens	P17706-1	Confocal	16595549
Intra	TMED9	Q9BVK6	PTPN2	Homo sapiens	P17706-1	Y2H	16595549
Intra	TMED9	Q9BVK6	PTPN2	Homo sapiens	P17706-1	Anti Tag CoIP	16595549

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TMED9 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76678	TMED9 Protein, Human (HEK293, His)	Q9BVK6/NP_059980.2 (L38-R202)	≥95%
HY-P76679	TMED9 Protein, Human (HEK293, Fc)	Q9BVK6 (M1-R202)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14640	TMED9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TMED9	RGD	RGD:1307627
Macaca mulatta	TMED9	VGNC	VGNC:110427
Mus musculus	TMED9	MGD	MGI:1914761
Others	TMED9	NCBI

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