2. Gene
  3. DPP8 - dipeptidyl peptidase 8 Gene

DPP8 - dipeptidyl peptidase 8 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DP8; DPRP1; DPRP-1; MST097; MSTP097; MSTP135; MSTP141

Gene ID: 54878 | Gene type: protein coding

About DPP8

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:65,442,467-65,517,689 (from NCBI)

This gene has 16 transcripts (splice variants), 133 orthologues and 6 paralogues. Ubiquitous expression in brain (RPKM 9.5), testis (RPKM 9.3) and 25 other tissues.

Summary

This gene encodes a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with Dipeptidyl Peptidase IV in that it is ubiquitously expressed, and hydrolyzes the same substrates. These similarities suggest that, like Dipeptidyl Peptidase IV, this protein may play a role in T-cell activation and immune function. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

DPP8 Products(6)

mRNA Protein Name
NM_001320875.2 NP_001307804.1 dipeptidyl peptidase 8 isoform 3
NM_001320876.2 NP_001307805.1 dipeptidyl peptidase 8 isoform 1
NM_017743.6 NP_060213.2 dipeptidyl peptidase 8 isoform 2
NM_130434.5 NP_569118.1 dipeptidyl peptidase 8 isoform 1
NM_197960.4 NP_932064.1 dipeptidyl peptidase 8 isoform 3
NM_197961.4 NP_932065.1 dipeptidyl peptidase 8 isoform 4
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables dipeptidyl-peptidase activity IDA
IDA: Inferred from direct assay
31525884 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
31525884 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of programmed cell death IDA
IDA: Inferred from direct assay
32796818 GOA
Cellular Component GO Annotation Evidence Reference Source
is active in cytoplasm IDA
IDA: Inferred from direct assay
12534281 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DPP8 Protein Structure

DPPIV_N

DPPIV_N: Dipeptidyl peptidase IV (DPP IV) N-terminal region (175 - 595)

Peptidase_S9

Peptidase_S9: Prolyl oligopeptidase family (687 - 890)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 898 a.a.
Protein Preferred Names Protein Names

dipeptidyl peptidase 8

DPP VIII

Related Diseases

Diseases Alias
Li-Fraumeni Syndrome 2

LFS2

Li-Fraumeni Syndrome, Type 2

Li-Fraumeni Syndrome
Nasopharyngitis

Chronic Nasopharyngitis

Chronic Rhinopharyngitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-A0023 Alogliptin Benzoate Inhibitor 99.99% Unkown
HY-A0023A Alogliptin Inhibitor 99.92% Unkown
HY-14877 Anagliptin Inhibitor 99.91% Unkown
HY-14877A Anagliptin hydrochloride Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-13233A Talabostat mesylate Inhibitor 98.16% Phase 3
HY-13233 Talabostat Inhibitor / Phase 3
Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-116304 1G244 98.66% Unkown
HY-A0023AS1 Alogliptin-d3 Inhibitor 99.61% Unkown
HY-151871 ICeD-2 Inhibitor / Unkown
HY-D2327 DPP-8/9 probe-1 Inhibitor / Unkown
HY-RS03968 DPP8 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-U00346A TS-021 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DPP8 MGD MGI:1921638
Felis catus DPP8 VGNC VGNC:61606
Bos taurus DPP8 VGNC VGNC:28189
Macaca mulatta DPP8 VGNC VGNC:71849
Rattus norvegicus DPP8 RGD RGD:1310901
Canis familiaris DPP8 VGNC VGNC:40077
Others DPP8 NCBI