1. Gene
  2. LAX1 - lymphocyte transmembrane adaptor 1 Gene

LAX1 - lymphocyte transmembrane adaptor 1 Gene

Homo sapiens

Also known as LAX

Gene ID: 54900 | Gene type: protein coding

About LAX1

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:203,765,183-203,776,372 (from NCBI)

This gene has 3 transcripts (splice variants) and 97 orthologues. Biased expression in lymph node (RPKM 6.4), appendix (RPKM 5.1) and 13 other tissues.

Summary

Enables SH2 domain binding activity and protein kinase binding activity. Involved in several processes, including B cell activation; negative regulation of MAP kinase activity; and negative regulation of T cell activation. Located in Golgi apparatus; cytosol; and plasma membrane. Is integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

LAX1 Products(3)

mRNA Protein Name
NM_001136190.2 NP_001129662.1 lymphocyte transmembrane adapter 1 isoform b
NM_001282878.1 NP_001269807.1 lymphocyte transmembrane adapter 1 isoform c
NM_017773.4 NP_060243.2 lymphocyte transmembrane adapter 1 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables SH2 domain binding IDA
IDA: Inferred from direct assay
12359715 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12359715 GOA
enables protein kinase binding IDA
IDA: Inferred from direct assay
12359715 GOA
Biological Process GO Annotation Evidence Reference Source
involved in B cell activation IDA
IDA: Inferred from direct assay
12359715 GOA
involved in immune response IDA
IDA: Inferred from direct assay
12359715 GOA
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
12359715 GOA
involved in negative regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
12359715 GOA
involved in negative regulation of T cell activation IDA
IDA: Inferred from direct assay
12359715 GOA
Cellular Component GO Annotation Evidence Reference Source
located in membrane IDA
IDA: Inferred from direct assay
12359715 GOA
NOT located in membrane raft IDA
IDA: Inferred from direct assay
12359715 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lymphocyte transmembrane adapter 1

LAT-like membrane associated protein

LAX1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
LAX1 Q8IWV1 STAMBPL1 Homo sapiens Q96FJ0
Y2H Prey Pooling
25416956
Intra
LAX1 Q8IWV1 STAMBPL1 Homo sapiens Q96FJ0
Y2H Array
25416956
Intra
LAX1 Q8IWV1 STAMBPL1 Homo sapiens Q96FJ0
Validated Y2H
25416956
Intra
LAX1 Q8IWV1 GRB7 Homo sapiens Q14451
Y2H Array
31515488
Intra
LAX1 Q8IWV1 GRB7 Homo sapiens Q14451
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Rheumatic Pulmonary Valve Disease

Rheumatic Disease Of Pulmonary Valve

Rheumatic Pulmonary Incompetence

Aortic Valve Insufficiency

Aortic Regurgitation

Rheumatic Aortic Regurgitation

Aortic Insufficiency

Rheumatic Aortic Insufficiency

Rheumatic Aortic Valve Insufficiency

Aortic Incompetence

Corrigan'S Disease

Rheumatic Aortic Valve Regurgitation

Aortic Valve Incompetency

Ai - [Aortic Incompetence]

Incompetent Aortic Valve

Ar - [Aortic Regurgitation]

Calcific Aortic Valve Regurgitation

Myxomatous Aortic Valve Regurgitation

Annular Incompetency Of Aortic Valve

Austin Flint Murmur

Flint Murmur

Rheumatic Aortic Incompetence

Rheumatic Ai - [Aortic Insufficiency]

Mitral Valve Insufficiency

Mitral Regurgitation

Congenital Insufficiency Of Mitral Valve

Congenital Mitral Insufficiency

Congenital Mitral Regurgitation

Mitral Valve Incompetence

Mitral Valve Regurgitation

Mr - [Mitral Regurgitation]

Mi - [Mitral Incompetence]

Mitral Valve Annular Incompetency

Congenital Mitral Valve Incompetence

Congenital Mitral Valve Insufficiency

Congenital Mitral Valve Regurgitation

Congenital Mitral Incompetence

Mitral Valve Disease

Chronic Rheumatic Mitral Valve

Rheumatic Mitral Insufficiency

Disease Of Mitral Valve

Mitral Rh Valve Dis.

Rheumatic Disease Of Mitral Valve

Rheumatic Mitral Valve Changes

Rheumatic Mitral Valve Incompetence

Rheumatic Mitral Valve Regurgitation

Abnormality Of The Mitral Valve

Diseases Of Mitral Valve

Rheumatic Mitral Regurgitation

Patent Foramen Ovale

Atrial Septal Defect Within Oval Fossa

Foramen Ovale Patent

Ostium Secundum Atrial Septal Defect

Atrial Septal Defect, Ostium Secundum Type

Foramen Ovale, Patent

Defect, Patent Or Persistent, Ostium Secundum

Ostium Secundum Type Atrial Septal Defect

Persistent Ostium Secundum

Asd Ostium Secundum Type

Ostium Secundum Asd

Osasd

Asd, Ostium Secundum Type

Pfo - [Patent Foramen Ovale]

Open Foramen Ovale

Open Oval Foramen

Persistent Foramen Ovale

Secundum Atrial Septal Defect

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus LAX1 RGD RGD:1563522
Bos taurus LAX1 VGNC VGNC:30802
Mus musculus LAX1 MGD MGI:2443362
Felis catus LAX1 VGNC VGNC:107891
Macaca mulatta LAX1 VGNC VGNC:106401
Canis familiaris LAX1 VGNC VGNC:42600