2. Gene
  3. GRB7 - growth factor receptor bound protein 7 Gene

GRB7 - growth factor receptor bound protein 7 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 2886 | Gene type: protein coding

About GRB7

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:39,737,938-39,747,285 (from NCBI)

This gene has 14 transcripts (splice variants), 197 orthologues and 4 paralogues. Broad expression in kidney (RPKM 6.4), esophagus (RPKM 5.5) and 16 other tissues.

Summary

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of Receptor Tyrosine Kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the Integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

GRB7 Products(5)

mRNA Protein Name
NM_001030002.3 NP_001025173.1 growth factor receptor-bound protein 7 isoform a
NM_001242442.2 NP_001229371.2 growth factor receptor-bound protein 7 isoform b
NM_001242443.2 NP_001229372.1 growth factor receptor-bound protein 7 isoform a
NM_001330207.2 NP_001317136.1 growth factor receptor-bound protein 7 isoform c
NM_005310.5 NP_005301.2 growth factor receptor-bound protein 7 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
15841400 GOA
enables phosphatidylinositol binding IDA
IDA: Inferred from direct assay
12021278 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
8940081 GOA
enables protein kinase binding IDA
IDA: Inferred from direct assay
12021278 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of cell migration IDA
IDA: Inferred from direct assay
10893408 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytosol IDA
IDA: Inferred from direct assay
10893408 GOA
located in focal adhesion IDA
IDA: Inferred from direct assay
10893408 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRB7 Protein Structure

RA

RA: Ras association (RalGDS/AF-6) domain (101 - 184)

PH

PH: PH domain (231 - 334)

BPS

BPS: BPS (Between PH and SH2) (365 - 412)

SH2

SH2: SH2 domain (431 - 512)

  • 0
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  • 500
  • 532 a.a.
Protein Preferred Names Protein Names

growth factor receptor-bound protein 7

B47

GRB7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
GRB7 Q14451 LAX1 Homo sapiens Q8IWV1
Validated Y2H
25416956
Intra
GRB7 Q14451 LAX1 Homo sapiens Q8IWV1
Y2H Prey Pooling
25416956
Intra
GRB7 Q14451 KIT Homo sapiens P10721
FPS
24728074
Intra
GRB7 Q14451 TRIM36 Homo sapiens Q9NQ86
Validated Y2H
25416956
Intra
GRB7 Q14451 KCTD6 Homo sapiens Q8NC69
Validated Y2H
25416956
Intra
GRB7 Q14451 KCTD6 Homo sapiens Q8NC69
Y2H Prey Pooling
25416956
Intra
GRB7 Q14451 HAX1 Homo sapiens O00165
Anti Bait CoIP
20665473
Intra
GRB7 Q14451 OLIG1 Homo sapiens Q8TAK6
Lumier
25814554
Intra
GRB7 Q14451 RND1 Homo sapiens Q92730
Y2H
10664463
Intra
GRB7 Q14451 AR Homo sapiens P10275
FPS
24728074
Intra
GRB7 Q14451 ERBB2 Homo sapiens P04626
NMR
12975581
Intra
GRB7 Q14451 ERBB2 Homo sapiens P04626
Protein Array
16273093
Intra
GRB7 Q14451 PDGFRB Homo sapiens P09619
Pull Down
8940081
Intra
GRB7 Q14451 PDGFRB Homo sapiens P09619
Competition Binding
8940081
Intra
GRB7 Q14451 LY6G6F Homo sapiens Q5SQ64
Anti Tag CoIP
12852788
Intra
GRB7 Q14451 PTK2 Homo sapiens Q05397
Y2H Array
25814554
Intra
GRB7 Q14451 PTK2 Homo sapiens Q05397
Lumier
25814554
Intra
GRB7 Q14451 ERBB3 Homo sapiens P21860
Competition Binding
9516479
Intra
GRB7 Q14451 ERBB3 Homo sapiens P21860
Protein Array
16273093
Intra
GRB7 Q14451 EPHB1 Homo sapiens P54762
Y2H
12223469
Cross
GRB7 Q14451 CALM Bos taurus P62157
Pull Down
15806159
Cross
GRB7 Q14451 Calm1 Rattus norvegicus P0DP29
Far-WB
15806159
Cross
GRB7 Q14451 Calm1 Rattus norvegicus P0DP29
Filter Binding
15806159
Cross: Cross-species interaction Intra: Intraspecies interaction

GRB7 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81420 GRB7 Antibody (YA1165) IHC-P Human

Related Diseases

Diseases Alias
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
Esophageal Cancer

Esophageal Carcinoma

Carcinoma Of Esophagus

Esophageal Squamous Cell Carcinoma, Somatic

Esophageal Carcinoma, Somatic

Esophagus Cancer

Gastric Cardia Adenocarcinoma

Esophageal Neoplasms

Esophageal Cancer, Somatic

Cancer Of Esophagus

Cancer Of Oesophagus

Carcinoma Of Oesophagus

Ca Lower Third Oesophagus

Ca Middle Third Oesophagus

Malignant Neoplasm Of Distal Third Of Esophagus

Malignant Neoplasm Of Lower Third Of Oesophagus

Malignant Neoplasm Of Middle Third Of Oesophagus

Malignant Neoplasm Of Proximal Third Of Esophagus

Malignant Neoplasm Of Upper Third Esophagus

Malignant Tumor Of Abdominal Esophagus

Malignant Tumor Of Distal Third Of Esophagus

Malignant Tumor Of Proximal Third Of Esophagus

Malignant Tumor Of The Middle Third Of The Esophagus

ESCR

Aerodigestive Tract Cancer

Escc

Esophageal Squamous Cell Carcinoma

Cancer, Esophageal

Malignant Neoplasm Of Esophagus

Squamous Cell Carcinoma Of Esophagus

Malignant Neoplasm Of Middle Third Of Esophagus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05781 GRB7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GRB7 MGD MGI:102683
Macaca mulatta GRB7 VGNC VGNC:73270
Canis familiaris GRB7 VGNC VGNC:41473
Bos taurus GRB7 VGNC VGNC:29632
Rattus norvegicus GRB7 RGD RGD:619759
Felis catus GRB7 VGNC VGNC:67458
Others GRB7 NCBI