C1orf56 - chromosome 1 open reading frame 56 Gene

Homo sapiens

Also known as MENT

Gene ID: 54964 | Gene type: protein coding

About C1orf56

This gene has 3 transcripts (splice variants) and 87 orthologues. Broad expression in testis (RPKM 26.8), spleen (RPKM 8.3) and 24 other tissues.

Summary

This gene is a proto-oncogene whose promoter is methylated by DNA Methyltransferase 3B (DNMT3B), which represses the proto-oncogene. However, a catalytically inactive isoform of DNMT3B is overexpressed in lymphomas, leading to hypomethylation of the proto-oncogene's promoter and derepression of the proto-oncogene. [provided by RefSeq, Sep 2016]

C1orf56 Products(1)

mRNA	Protein	Name
NM_017860.5	NP_060330.2	protein MENT precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	22133874	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

C1orf56 Protein Structure

PMSI1

0
100
200
300
341 a.a.

Protein Preferred Names

Protein Names

protein MENT

methylated in normal thymocytes protein

C1orf56 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MENT	Q9BUN1	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	MENT	Q9BUN1	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	MENT	Q9BUN1	TCF4	Homo sapiens	P15884-3	Y2H Prey Pooling	32296183
Intra	MENT	Q9BUN1	TCF4	Homo sapiens	P15884-3	Y2H Array	32296183
Intra	MENT	Q9BUN1	COX20	Homo sapiens	Q5RI15	Y2H Prey Pooling	32296183
Intra	MENT	Q9BUN1	COX20	Homo sapiens	Q5RI15	Y2H Array	32296183
Intra	MENT	Q9BUN1	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	MENT	Q9BUN1	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	MENT	Q9BUN1	CRX	Homo sapiens	O43186	Y2H Array	32296183
Intra	MENT	Q9BUN1	CRX	Homo sapiens	O43186	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Corneal Dystrophy, Posterior Polymorphous, 1

Posterior Polymorphous Corneal Dystrophy	Ppcd
Maumenee Corneal Dystrophy	Posterior Polymorphous Corneal Dystrophy 1
PPCD1	Corneal Dystrophy, Hereditary Polymorphous Posterior
Corneal Endothelial Dystrophy 1, Autosomal Dominant	Schlichting Dystrophy
Ched1	Corneal Endothelial Dystrophy 1, Autosomal Dominant, Formerly
Ched1, Formerly	Hereditary Polymorphus Posterior Corneal Dystrophy
Posterior Polymorphous Dystrophy	Hereditary Polymorphous Posterior Corneal Dystrophy
Dystrophy, Corneal, Posterior Polymorphous	Dystrophy, Corneal, Posterior Polymorphous, Type 1
Polymorphous Corneal Dystrophy	Corneal Endothelial Dystrophy 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01717	C1orf56 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	C1orf56	RGD	RGD:1359334
Mus musculus	C1orf56	MGD	MGI:2684974
Macaca mulatta	C1orf56	VGNC	VGNC:70392
Bos taurus	C1orf56	VGNC	VGNC:52715
Canis familiaris	C1orf56	VGNC	VGNC:49219

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