HPF1 - histone PARylation factor 1 Gene

Homo sapiens

Also known as C4orf27

Gene ID: 54969 | Gene type: protein coding

About HPF1

Cytogenetic location: 4q33 Genomic coordinates (GRCh38): 4:169,729,470-169,757,944 (from NCBI)

This gene has 3 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in brain (RPKM 6.3), endometrium (RPKM 6.0) and 25 other tissues.

Summary

Enables chromatin binding activity and histone binding activity. Involved in double-strand break repair; peptidyl-serine ADP-ribosylation; and regulation of protein modification process. Located in chromatin; nucleus; and site of DNA damage. [provided by Alliance of Genome Resources, Apr 2022]

HPF1 Products(1)

mRNA	Protein	Name
NM_017867.3	NP_060337.2	histone PARylation factor 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	32939087	GOA
enables histone binding	IDA IDA: Inferred from direct assay	27067600	GOA
enables protein ADP-ribosyltransferase-substrate adaptor activity	IDA IDA: Inferred from direct assay	28190768	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	27067600	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	27067600	GOA
involved in DNA repair	IDA IDA: Inferred from direct assay	32028527	GOA
involved in DNA repair-dependent chromatin remodeling	IDA IDA: Inferred from direct assay	32939087	GOA
involved in double-strand break repair	IDA IDA: Inferred from direct assay	32028527	GOA
involved in regulation of protein ADP-ribosylation	IDA IDA: Inferred from direct assay	33186521	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	27067600	GOA
located in nucleus	IDA IDA: Inferred from direct assay	27067600	GOA
is active in site of DNA damage	IDA IDA: Inferred from direct assay	32028527	GOA
located in site of DNA damage	IDA IDA: Inferred from direct assay	32939087	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HPF1 Protein Structure

DUF2228

0
100
200
300
346 a.a.

Protein Preferred Names

Protein Names

histone PARylation factor 1

UPF0609 protein C4orf27

Related Diseases

Diseases

Alias

Neurodegeneration, Childhood-Onset, Stress-Induced, With Variable Ataxia And Seizures

CONDSIAS

Stress-Induced Childhood-Onset Neurodegeneration With Variable Ataxia And Seizures

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06337	HPF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HPF1	MGD	MGI:1919862
Bos taurus	HPF1	VGNC	VGNC:56972
Macaca mulatta	HPF1	VGNC	VGNC:100235
Rattus norvegicus	HPF1	RGD	RGD:1311747
Canis familiaris	HPF1	VGNC	VGNC:50635
Felis catus	HPF1	VGNC	VGNC:78510

Name
Email *

	Sorry, but the email address you supplied was invalid.