GID8 - GID complex subunit 8 homolog Gene

Homo sapiens

Also known as TWA1; C20orf11

Gene ID: 54994 | Gene type: protein coding

About GID8

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:62,938,147-62,948,475 (from NCBI)

This gene has 2 transcripts (splice variants), 278 orthologues and 3 paralogues. Ubiquitous expression in esophagus (RPKM 17.5), ovary (RPKM 15.5) and 25 other tissues.

Summary

Predicted to enable protein homodimerization activity. Involved in positive regulation of canonical Wnt signaling pathway and positive regulation of cell population proliferation. Located in cell junction; cytosol; and nucleoplasm. Part of ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

GID8 Products(1)

mRNA	Protein	Name
NM_017896.3	NP_060366.1	glucose-induced degradation protein 8 homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	27173435	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	28829046	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	28829046	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17467196	GOA
located in cytosol	IDA IDA: Inferred from direct assay	24143168	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17467196	GOA
part of ubiquitin ligase complex	IDA IDA: Inferred from direct assay	29911972	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GID8 Protein Structure

LisH

CLTH

0
100
200
228 a.a.

Protein Preferred Names

Protein Names

glucose-induced degradation protein 8 homolog

protein C20orf11

GID8 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GID8	Q9NWU2	RMND5A	Homo sapiens	Q9H871	TAP	27173435
Intra	GID8	Q9NWU2	RMND5A	Homo sapiens	Q9H871	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Lissencephaly

Pachygyria	Broad Gyri Of Cerebrum
Large Gyri Of Cerebrum	Macrogyria

Lissencephaly 1

LIS1	Classic Lissencephaly
Ils	Subcortical Laminar Heterotopia
Lissencephaly Due To Lis1 Mutation	Lissencephaly Sequence, Isolated
Lissencephaly, Classic	Pafah1b1-Related Lissencephaly
Classical Lissencephaly	Lissencephaly Type 1
Lissencephaly-1	Subcortical Band Heterotopia
Double Cortex	Lissencephaly Classic
Lissencephaly Sequence Isolated	Isolated Lissencephaly Sequence
Type 1 Lissencephaly	Lissencephaly Syndrome Type 1
SBH	Sclh
Lissencephaly, Type 1	Type I Lissencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05420	GID8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GID8	RGD	RGD:735024
Bos taurus	GID8	VGNC	VGNC:29353
Macaca mulatta	GID8	VGNC	VGNC:72949
Canis familiaris	GID8	VGNC	VGNC:41211
Mus musculus	GID8	MGD	MGI:1923675

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