AURKAIP1 - aurora kinase A interacting protein 1 Gene

Homo sapiens

Also known as AIP; AKIP; MRP-S38

Gene ID: 54998 | Gene type: protein coding

About AURKAIP1

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:1,373,736-1,375,207 (from NCBI)

This gene has 6 transcripts (splice variants) and 189 orthologues. Ubiquitous expression in testis (RPKM 40.0), kidney (RPKM 27.3) and 25 other tissues.

Summary

Acts upstream of or within positive regulation of proteolysis. Located in mitochondrion and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

AURKAIP1 Products(3)

mRNA	Protein	Name
NM_001127229.2	NP_001120701.1	aurora kinase A-interacting protein
NM_001127230.2	NP_001120702.1	aurora kinase A-interacting protein
NM_017900.3	NP_060370.1	aurora kinase A-interacting protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12244051	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within positive regulation of proteolysis	IDA IDA: Inferred from direct assay	12244051	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	27184847	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12244051	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AURKAIP1 Protein Structure

DUF1713

0
100
199 a.a.

Protein Preferred Names

Protein Names

aurora kinase A-interacting protein

28S ribosomal protein S38, mitochondrial

Related Diseases

Diseases

Alias

Hermansky-Pudlak Syndrome 3

HPS3	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial
Delta Storage Pool Disease	Hermansky-Pudlak Syndrome, Type 3
Platelet Storage Pool Deficiency	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01269	AURKAIP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	AURKAIP1	VGNC	VGNC:56004
Macaca mulatta	AURKAIP1	VGNC	VGNC:106321
Bos taurus	AURKAIP1	VGNC	VGNC:26350
Mus musculus	AURKAIP1	MGD	MGI:1913327
Felis catus	AURKAIP1	VGNC	VGNC:60043

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