USP47 - ubiquitin specific peptidase 47 Gene

Homo sapiens

Also known as TRFP

Gene ID: 55031 | Gene type: protein coding

About USP47

Cytogenetic location: 11p15.3 Genomic coordinates (GRCh38): 11:11,841,972-11,961,887 (from NCBI)

This gene has 11 transcripts (splice variants), 207 orthologues and 71 paralogues. Ubiquitous expression in brain (RPKM 11.7), heart (RPKM 10.2) and 25 other tissues.

Summary

Enables WD40-repeat domain binding activity and thiol-dependent Deubiquitinase. Involved in several processes, including monoubiquitinated protein deubiquitination; negative regulation of G2/M transition of mitotic cell cycle; and negative regulation of nitrogen compound metabolic process. Located in cytoplasm. Part of SCF ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

USP47 Products(16)

mRNA	Protein	Name
NM_001282659.2	NP_001269588.1	ubiquitin carboxyl-terminal hydrolase 47 isoform a
NM_001330208.2	NP_001317137.1	ubiquitin carboxyl-terminal hydrolase 47 isoform c
NM_001372091.1	NP_001359020.1	ubiquitin carboxyl-terminal hydrolase 47 isoform d
NM_001372092.1	NP_001359021.1	ubiquitin carboxyl-terminal hydrolase 47 isoform e
NM_001372093.1	NP_001359022.1	ubiquitin carboxyl-terminal hydrolase 47 isoform f
NM_001372094.1	NP_001359023.1	ubiquitin carboxyl-terminal hydrolase 47 isoform f
NM_001372095.1	NP_001359024.1	ubiquitin carboxyl-terminal hydrolase 47 isoform g
NM_001372096.1	NP_001359025.1	ubiquitin carboxyl-terminal hydrolase 47 isoform h
NM_001372097.1	NP_001359026.1	ubiquitin carboxyl-terminal hydrolase 47 isoform i
NM_001372098.1	NP_001359027.1	ubiquitin carboxyl-terminal hydrolase 47 isoform j
NM_001372099.1	NP_001359028.1	ubiquitin carboxyl-terminal hydrolase 47 isoform k
NM_001372100.1	NP_001359029.1	ubiquitin carboxyl-terminal hydrolase 47 isoform l
NM_001372101.1	NP_001359030.1	ubiquitin carboxyl-terminal hydrolase 47 isoform n
NM_001372102.1	NP_001359031.1	ubiquitin carboxyl-terminal hydrolase 47 isoform o
NM_001372103.1	NP_001359032.1	ubiquitin carboxyl-terminal hydrolase 47 isoform m
NM_017944.4	NP_060414.3	ubiquitin carboxyl-terminal hydrolase 47 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables WD40-repeat domain binding	IPI IPI: Inferred from physical interaction	19966869	GOA
enables cysteine-type deubiquitinase activity	IDA IDA: Inferred from direct assay	21362556	GOA
enables deubiquitinase activity	IDA IDA: Inferred from direct assay	26169834	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21362556	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	21362556	GOA
involved in base-excision repair	IMP IMP: Inferred from mutant phenotype	21362556	GOA
involved in monoubiquitinated protein deubiquitination	IDA IDA: Inferred from direct assay	21362556	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19966869	GOA
involved in negative regulation of G2/M transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	19966869	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	19966869	GOA
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	19966869	GOA
involved in positive regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	26169834	GOA
involved in positive regulation of cell growth	IMP IMP: Inferred from mutant phenotype	19966869	GOA
involved in response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	19966869	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of SCF ubiquitin ligase complex	IDA IDA: Inferred from direct assay	19966869	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	21362556	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	36749823	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP47 Protein Structure

UCH

0
300
600
900
1200
1375 a.a.

Protein Preferred Names

Protein Names

ubiquitin carboxyl-terminal hydrolase 47

Trf (TATA binding protein-related factor)-proximal homolog

USP47 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	USP47	Q96K76	AP4M1	Homo sapiens	O00189	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13865	P 22077	Inhibitor	98.07%	Unkown
HY-112937	GNE-6640	Inhibitor	99.91%	Unkown
HY-13487	USP7/USP47 inhibitor	Inhibitor	98.58%	Unkown
HY-134817	USP7-IN-8	Inhibitor	99.04%	Unkown
HY-RS15558	USP47 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-111166	USP7/USP47 inhibitor 1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	USP47	RGD	RGD:1310411
Bos taurus	USP47	VGNC	VGNC:36732
Felis catus	USP47	VGNC	VGNC:66890
Mus musculus	USP47	MGD	MGI:1922246
Macaca mulatta	USP47	VGNC	VGNC:79230
Canis familiaris	USP47	VGNC	VGNC:48198
Others	USP47	NCBI

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