2. Gene
  3. NRDE2 - NRDE-2, necessary for RNA interference, domain containing Gene

NRDE2 - NRDE-2, necessary for RNA interference, domain containing Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as C14orf102

Gene ID: 55051 | Gene type: protein coding

About NRDE2

Cytogenetic location: 14q32.11 Genomic coordinates (GRCh38): 14:90,267,860-90,331,941 (from NCBI)

This gene has 10 transcripts (splice variants) and 190 orthologues. Ubiquitous expression in duodenum (RPKM 3.4), thyroid (RPKM 3.4) and 25 other tissues.

Summary

Involved in several processes, including RNA splicing; negative regulation of RNA catabolic process; and positive regulation of RNA export from nucleus. Located in nuclear speck and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

NRDE2 Products(1)

mRNA Protein Name
NM_017970.4 NP_060440.2 nuclear exosome regulator NRDE2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
29902117 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA damage response IMP
IMP: Inferred from mutant phenotype
29902117 GOA
involved in RNA splicing IMP
IMP: Inferred from mutant phenotype
30538148 GOA
involved in mRNA stabilization IMP
IMP: Inferred from mutant phenotype
30842217 GOA
involved in mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
30538148 GOA
involved in positive regulation of RNA export from nucleus IMP
IMP: Inferred from mutant phenotype
30842217 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nuclear speck IDA
IDA: Inferred from direct assay
30538148 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
30842217 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
30538148 GOA
located in nucleus IDA
IDA: Inferred from direct assay
29902117 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NRDE2 Protein Structure

NRDE-2

NRDE-2: NRDE-2, necessary for RNA interference (308 - 649)

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  • 1164 a.a.
Protein Preferred Names Protein Names

nuclear exosome regulator NRDE2

UPF0614 protein C14orf102

NRDE2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra NRDE2 Q9H7Z3 UQCC2 Homo sapiens Q9BRT2
Y2H Array
32296183
Intra NRDE2 Q9H7Z3 UQCC2 Homo sapiens Q9BRT2
Y2H Prey Pooling
32296183
Intra NRDE2 Q9H7Z3 LHX3 Homo sapiens Q9UBR4-2
Validated Y2H
32296183
Intra NRDE2 Q9H7Z3 LHX3 Homo sapiens Q9UBR4-2
Y2H Array
32296183
Intra NRDE2 Q9H7Z3 LHX3 Homo sapiens Q9UBR4-2
Y2H Prey Pooling
32296183
Intra NRDE2 Q9H7Z3 VPS28 Homo sapiens Q9UK41-2
Y2H Prey Pooling
32296183
Intra NRDE2 Q9H7Z3 VPS28 Homo sapiens Q9UK41-2
Validated Y2H
32296183
Intra NRDE2 Q9H7Z3 VPS28 Homo sapiens Q9UK41-2
Y2H Array
32296183
Intra NRDE2 Q9H7Z3 RCOR3 Homo sapiens Q9P2K3-2
Validated Y2H
32296183
Intra NRDE2 Q9H7Z3 CCDC183 Homo sapiens G5E9W6
Y2H Prey Pooling
32296183
Intra NRDE2 Q9H7Z3 CCDC183 Homo sapiens G5E9W6
Y2H Array
32296183
Intra NRDE2 Q9H7Z3 HAUS8 Homo sapiens Q9BT25
Y2H Prey Pooling
32296183
Intra NRDE2 Q9H7Z3 HAUS8 Homo sapiens Q9BT25
Y2H Array
32296183
Intra NRDE2 Q9H7Z3 MED29 Homo sapiens Q9NX70
Y2H Array
32296183
Intra NRDE2 Q9H7Z3 MED29 Homo sapiens Q9NX70
Y2H Prey Pooling
32296183
Intra NRDE2 Q9H7Z3 MED29 Homo sapiens Q9NX70
Validated Y2H
32296183
Intra NRDE2 Q9H7Z3 MESD Homo sapiens Q14696
Y2H Prey Pooling
32296183
Intra NRDE2 Q9H7Z3 MESD Homo sapiens Q14696
Y2H Array
32296183
Intra NRDE2 Q9H7Z3 ITGB3BP Homo sapiens Q13352
Y2H Array
32296183
Intra NRDE2 Q9H7Z3 ITGB3BP Homo sapiens Q13352
Y2H Prey Pooling
32296183
Intra NRDE2 Q9H7Z3 SPG21 Homo sapiens Q9NZD8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hypertrichosis Universalis Congenita, Ambras Type

Ambras Syndrome

Hypertrichosis, Congenital Generalized

HTC1

HTC2

Chromosome Xq27.1 Interchromosomal Insertion Syndrome

Cgh

Hcg

Ambras Type Hypertrichosis Universalis Congenita

X-Linked Congenital Generalized Hypertrichosis

Congenital Generalized Hypertrichosis, Macias-Flores Type

Macias Flores-Garcia Cruz-Rivera Syndrome

Htc 1

Hypertrichosis Universalis Congenita Ambras Type

Hypertrichosis Congenital Generalized X-Linked

Macias-Flores Garcia-Cruz Rivera Syndrome

Congenital Generalized Hypertrichosis, Ambras Type
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09565 NRDE2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NRDE2 VGNC VGNC:32259
Rattus norvegicus NRDE2 RGD RGD:1565082
Mus musculus NRDE2 MGD MGI:2670969
Macaca mulatta NRDE2 VGNC VGNC:75440
Canis familiaris NRDE2 VGNC VGNC:43965
Felis catus NRDE2 VGNC VGNC:63878