TAPBPL - TAP binding protein like Gene

Homo sapiens

Also known as TAPBPR; TAPBP-R

Gene ID: 55080 | Gene type: protein coding

About TAPBPL

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:6,451,649-6,472,006 (from NCBI)

This gene has 8 transcripts (splice variants), 182 orthologues and 2 paralogues. Ubiquitous expression in duodenum (RPKM 8.1), small intestine (RPKM 7.3) and 25 other tissues.

Summary

Tapasin, or TAPBP (MIM 601962), is a member of the variable-constant Ig superfamily that links major histocompatibility complex (MHC) class I molecules to the transporter associated with antigen processing (TAP; see MIM 170260) in the endoplasmic reticulum (ER). The TAPBP gene is located near the MHC complex on chromosome 6p21.3. TAPBPL is a member of the Ig superfamily that is localized on chromosome 12p13.3, a region somewhat paralogous to the MHC.[supplied by OMIM, Mar 2008]

TAPBPL Products(2)

mRNA	Protein	Name
NM_001351355.2	NP_001338284.1	tapasin-related protein isoform 2
NM_018009.5	NP_060479.3	tapasin-related protein isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables MHC class I protein complex binding	IDA IDA: Inferred from direct assay	23401559	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23401559	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of antigen processing and presentation of peptide antigen via MHC class I	IDA IDA: Inferred from direct assay	23401559	GOA
involved in peptide antigen assembly with MHC class I protein complex	IDA IDA: Inferred from direct assay	26869717	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	23401559	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAPBPL Protein Structure

V-set

C1-set

0
100
200
300
400
468 a.a.

Protein Preferred Names

Protein Names

tapasin-related protein

TAP binding protein related

TAPBPL Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TAPBPL	Q9BX59	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	TAPBPL	Q9BX59	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	TAPBPL	Q9BX59	HLA-B	Homo sapiens	P01889	Anti Bait CoIP	26439010
Intra	TAPBPL	Q9BX59	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	TAPBPL	Q9BX59	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	TAPBPL	Q9BX59	KRT35	Homo sapiens	Q92764	Y2H Array	32296183
Intra	TAPBPL	Q9BX59	KRT35	Homo sapiens	Q92764	Y2H Prey Pooling	32296183
Intra	TAPBPL	Q9BX59	TEPSIN	Homo sapiens	Q96N21	Y2H Prey Pooling	32296183
Intra	TAPBPL	Q9BX59	TEPSIN	Homo sapiens	Q96N21	Y2H Array	32296183
Intra	TAPBPL	Q9BX59	PM20D2	Homo sapiens	Q8IYS1	Y2H Array	32296183
Intra	TAPBPL	Q9BX59	PM20D2	Homo sapiens	Q8IYS1	Y2H Prey Pooling	32296183
Intra	TAPBPL	Q9BX59	TCF4	Homo sapiens	P15884-3	Y2H Prey Pooling	32296183
Intra	TAPBPL	Q9BX59	TCF4	Homo sapiens	P15884-3	Y2H Array	32296183
Intra	TAPBPL	Q9BX59	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	TAPBPL	Q9BX59	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	TAPBPL	Q9BX59	HLA-A	Homo sapiens	P01892	Anti Bait CoIP	26439010
Intra	TAPBPL	Q9BX59	HLA-A	Homo sapiens	P01892	Anti Bait CoIP	24163410
Intra	TAPBPL	Q9BX59	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	TAPBPL	Q9BX59	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	TAPBPL	Q9BX59	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	TAPBPL	Q9BX59	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spastic Ataxia 1, Autosomal Dominant

SPAX1	Ataxia, Spastic, 1, Autosomal Dominant
Autosomal Dominant Spastic Ataxia Type 1	Ataxia, Spastic, Type 1, Autosomal Dominant

Spastic Ataxia 1

Myasthenic Syndrome, Congenital, 25, Presynaptic

CMS25

Myasthenic Syndrome, Congenital, 25

Congenital Myasthenic Syndrome

Congenital Myasthenia	Congenital Myasthenic Syndromes
Cms	Myasthenic Syndromes, Congenital
Myasthenic Syndromes Congenital	Myasthenic Syndrome, Congenital
Congenital Myasthenic Syndrome Ib	Congenital And Developmental Myasthenia
Developmental Myasthenia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14204	TAPBPL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TAPBPL	MGD	MGI:2384853
Felis catus	TAPBPL	VGNC	VGNC:65953
Rattus norvegicus	TAPBPL	RGD	RGD:1307893
Canis familiaris	TAPBPL	VGNC	VGNC:47107
Bos taurus	TAPBPL	VGNC	VGNC:35600
Macaca mulatta	TAPBPL	NCBI	NCBI:712626
Others	TAPBPL	NCBI

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