2. Gene
  3. RALGPS2 - Ral GEF with PH domain and SH3 binding motif 2 Gene

RALGPS2 - Ral GEF with PH domain and SH3 binding motif 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as dJ595C2.1

Gene ID: 55103 | Gene type: protein coding

About RALGPS2

Cytogenetic location: 1q25.2 Genomic coordinates (GRCh38): 1:178,725,244-178,921,840 (from NCBI)

This gene has 8 transcripts (splice variants), 204 orthologues and 24 paralogues. Broad expression in testis (RPKM 23.5), lymph node (RPKM 18.8) and 22 other tissues.

Summary

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of Ral protein signal transduction; regulation of catalytic activity; and small GTPase mediated signal transduction. Predicted to be located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

RALGPS2 Products(3)

mRNA Protein Name
NM_001286247.2 NP_001273176.1 ras-specific guanine nucleotide-releasing factor RalGPS2 isoform 2
NM_001400042.1 NP_001386971.1 ras-specific guanine nucleotide-releasing factor RalGPS2 isoform 3
NM_152663.5 NP_689876.2 ras-specific guanine nucleotide-releasing factor RalGPS2 isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15778465 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RALGPS2 Protein Structure

RasGEF

RasGEF: RasGEF domain (47 - 219)

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  • 583 a.a.
Protein Preferred Names Protein Names

ras-specific guanine nucleotide-releasing factor RalGPS2

Ral-A exchange factor RalGPS2

RALGPS2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
RALGPS2 Q86X27 OSBPL3 Homo sapiens Q9H4L5
Validated Y2H
32296183
Intra
RALGPS2 Q86X27 OSBPL3 Homo sapiens Q9H4L5
Y2H Array
32296183
Intra
RALGPS2 Q86X27 OSBPL3 Homo sapiens Q9H4L5
Y2H Prey Pooling
32296183
Intra
RALGPS2 Q86X27 YWHAE Homo sapiens P62258
Crosslink
36931259
Intra
RALGPS2 Q86X27 SFN Homo sapiens P31947
TAP
15778465
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P10760 PhAc-ALGP-Dox / Unkown
HY-RS11634 RALGPS2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta RALGPS2 VGNC VGNC:76572
Felis catus RALGPS2 VGNC VGNC:64486
Canis familiaris RALGPS2 VGNC VGNC:45336
Rattus norvegicus RALGPS2 RGD RGD:1311537
Mus musculus RALGPS2 MGD MGI:1925505
Bos taurus RALGPS2 VGNC VGNC:33705