2. Gene
  3. ODAD2 - outer dynein arm docking complex subunit 2 Gene

ODAD2 - outer dynein arm docking complex subunit 2 Gene

  • Gene
  • Protein
Homo sapiens (human)

Also known as gudu; ARMC4; CILD23

Gene ID: 55130 | Gene type: protein coding

About ODAD2

Summary

The protein encoded by this gene contains ten Armadillo repeat motifs (ARMs) and one HEAT repeat, and is thought to be involved in ciliary and flagellar movement. This protein has been shown to localize to the ciliary axonemes and at the ciliary base of respiratory cells. Studies indicate that mutations in this gene cause partial outer dynein arm (ODA) defects in respiratory cilia. The cilia of cells with mutations in this gene displayed either reduced ciliary beat frequency and amplitude, or, complete immotility. Some individuals with primary ciliary dyskensia (PCD) have been shown to have mutations in this gene. PCD is characterized by chronic airway disease and left/right body asymmetry defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]

ODAD2 Products(1)

mRNA Protein Name
XM_047425411.1 XP_047281367.1 outer dynein arm-docking complex subunit 2 isoform X8
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cilium movement IMP
IMP: Inferred from mutant phenotype
23849778 GOA
acts upstream of or within determination of left/right symmetry IMP
IMP: Inferred from mutant phenotype
23849778 GOA
acts upstream of or within outer dynein arm assembly IMP
IMP: Inferred from mutant phenotype
23849778 GOA
acts upstream of or within regulation of cilium beat frequency IMP
IMP: Inferred from mutant phenotype
24203976 GOA
Cellular Component GO Annotation Evidence Reference Source
located in axoneme IDA
IDA: Inferred from direct assay
23849778 GOA
located in ciliary base IDA
IDA: Inferred from direct assay
23849778 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

outer dynein arm-docking complex subunit 2

armadillo repeat containing 4

armadillo repeat-containing protein 4

testis tissue sperm-binding protein Li 74n

ODAD2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ODAD2 Q5T2S8 NR4A2 Homo sapiens P43354
Y2H Prey Pooling
32296183
Intra
ODAD2 Q5T2S8 NR4A2 Homo sapiens P43354
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction