NADSYN1 - NAD synthetase 1 Gene

Homo sapiens

Also known as VCRL3

Gene ID: 55191 | Gene type: protein coding

About NADSYN1

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:71,453,203-71,501,816 (from NCBI)

This gene has 23 transcripts (splice variants), 212 orthologues and is associated with 3 phenotypes. Ubiquitous expression in bone marrow (RPKM 25.3), duodenum (RPKM 20.8) and 25 other tissues.

Summary

Nicotinamide adenine dinucleotide (NAD) is a coenzyme in metabolic redox reactions, a precursor for several cell signaling molecules, and a substrate for protein posttranslational modifications. NAD synthetase (EC 6.3.5.1) catalyzes the final step in the biosynthesis of NAD from nicotinic acid adenine dinucleotide (NaAD).[supplied by OMIM, Apr 2004]

NADSYN1 Products(1)

mRNA	Protein	Name
NM_018161.5	NP_060631.2	glutamine-dependent NAD(+) synthetase

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables NAD+ synthase (glutamine-hydrolyzing) activity	IMP IMP: Inferred from mutant phenotype	31883644	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in 'de novo' NAD biosynthetic process	IMP IMP: Inferred from mutant phenotype	31883644	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NADSYN1 Protein Structure

CN_hydrolase

NAD_synthase

0
200
400
600
706 a.a.

Protein Preferred Names

Protein Names

glutamine-dependent NAD(+) synthetase

NAD(+) synthase

Related Diseases

Diseases

Alias

Vertebral, Cardiac, Renal, And Limb Defects Syndrome 3

VCRL3	Congenital Nad Deficiency Disorder 3
Congenital Nad Deficiency Disorder

Congenital Vertebral-Cardiac-Renal Anomalies Syndrome

Congenital Nad Deficiency Disorder

Superficial Keratitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09006	NADSYN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NADSYN1	MGD	MGI:1926164
Canis familiaris	NADSYN1	VGNC	VGNC:43606
Macaca mulatta	NADSYN1	VGNC	VGNC:75048
Bos taurus	NADSYN1	VGNC	VGNC:31865
Rattus norvegicus	NADSYN1	RGD	RGD:727801
Felis catus	NADSYN1	VGNC	VGNC:63711

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