TFG - trafficking from ER to golgi regulator Gene

Homo sapiens

Also known as TF6; HMSNP; SPG57; TRKT3

Gene ID: 10342 | Gene type: protein coding

About TFG

Cytogenetic location: 3q12.2 Genomic coordinates (GRCh38): 3:100,709,290-100,748,967 (from NCBI)

This gene has 36 transcripts (splice variants), 217 orthologues and is associated with 67 phenotypes. Ubiquitous expression in duodenum (RPKM 35.2), placenta (RPKM 33.3) and 25 other tissues.

Summary

There are several documented fusion oncoproteins encoded partially by this gene. This gene also participates in several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may play a role in the NF-kappaB pathway. Multiple transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]

TFG Products(4)

mRNA	Protein	Name
NM_001007565.2	NP_001007566.1	protein TFG isoform 1
NM_001195478.2	NP_001182407.1	protein TFG isoform 1
NM_001195479.2	NP_001182408.1	protein TFG isoform 2
NM_006070.6	NP_006061.2	protein TFG isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16169070	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	21478858	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum exit site	IDA IDA: Inferred from direct assay	21478858	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TFG Protein Structure

PB1

0
100
200
300
400 a.a.

Protein Preferred Names

Protein Names

protein TFG

TRK-fused

TFG Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TFG	Q92734	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
Intra	TFG	Q92734	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	ANXA11	Homo sapiens	Q5T0G8	Y2H Array	25416956
Intra	TFG	Q92734	ANXA11	Homo sapiens	Q5T0G8	Y2H Prey Pooling	25416956
Intra	TFG	Q92734	ANXA11	Homo sapiens	Q5T0G8	Validated Y2H	25416956
Intra	TFG	Q92734	NID2	Homo sapiens	Q8IV28	Y2H Array	32296183
Intra	TFG	Q92734	NID2	Homo sapiens	Q8IV28	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	ARHGEF16	Homo sapiens	Q5VV41	Y2H Prey Pooling	25416956
Intra	TFG	Q92734	MSS51	Homo sapiens	Q4VC12	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	ACTMAP	Homo sapiens	Q5BKX5-3	Y2H Array	32296183
Intra	TFG	Q92734	ACTMAP	Homo sapiens	Q5BKX5-3	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	FAM168A	Homo sapiens	Q92567-2	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	FAM168A	Homo sapiens	Q92567-2	Y2H Array	32296183
Intra	TFG	Q92734	BOLL	Homo sapiens	Q8N9W6-4	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	BOLL	Homo sapiens	Q8N9W6-4	Y2H Array	32296183
Intra	TFG	Q92734	SAXO4	Homo sapiens	Q7Z5V6-2	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	SAXO4	Homo sapiens	Q7Z5V6-2	Y2H Array	32296183
Intra	TFG	Q92734	WWOX	Homo sapiens	Q9NZC7-5	Y2H Array	32296183
Intra	TFG	Q92734	WWOX	Homo sapiens	Q9NZC7-5	Validated Y2H	32296183
Intra	TFG	Q92734	WWOX	Homo sapiens	Q9NZC7-5	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	TBX19	Homo sapiens	O60806	Y2H Array	32296183
Intra	TFG	Q92734	TBX19	Homo sapiens	O60806	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	SMUG1	Homo sapiens	Q53HV7-2	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	SMUG1	Homo sapiens	Q53HV7-2	Y2H Array	32296183
Intra	TFG	Q92734	PRR20D	Homo sapiens	P86480	Y2H Array	32296183
Intra	TFG	Q92734	PRR20D	Homo sapiens	P86480	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	EYA2	Homo sapiens	O00167-2	Y2H Array	32296183
Intra	TFG	Q92734	EYA2	Homo sapiens	O00167-2	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	OXER1	Homo sapiens	Q8TDS5	Y2H Array	32296183
Intra	TFG	Q92734	OXER1	Homo sapiens	Q8TDS5	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	STH	Homo sapiens	Q8IWL8	Y2H Array	32296183
Intra	TFG	Q92734	STH	Homo sapiens	Q8IWL8	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	FOXH1	Homo sapiens	O75593	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	FOXH1	Homo sapiens	O75593	Y2H Array	32296183
Intra	TFG	Q92734	ZMYM5	Homo sapiens	Q9UJ78-2	Y2H Array	32296183
Intra	TFG	Q92734	ZMYM5	Homo sapiens	Q9UJ78-2	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	ZMYM5	Homo sapiens	Q9UJ78-2	Validated Y2H	32296183
Intra	TFG	Q92734	RNF4	Homo sapiens	P78317	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	RNF4	Homo sapiens	P78317	Y2H Array	32296183
Intra	TFG	Q92734	SF3A2	Homo sapiens	Q15428	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	SF3A2	Homo sapiens	Q15428	Y2H Array	32296183
Intra	TFG	Q92734	UBAP2	Homo sapiens	Q5T6F2	Y2H Array	32296183
Intra	TFG	Q92734	UBAP2	Homo sapiens	Q5T6F2	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	VPS37C	Homo sapiens	A5D8V6	Y2H Array	25416956
Intra	TFG	Q92734	VPS37C	Homo sapiens	A5D8V6	Y2H Array	32296183
Intra	TFG	Q92734	VPS37C	Homo sapiens	A5D8V6	Y2H Prey Pooling	25416956
Intra	TFG	Q92734	VPS37C	Homo sapiens	A5D8V6	Validated Y2H	25416956
Intra	TFG	Q92734	VPS37C	Homo sapiens	A5D8V6	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	SF3B4	Homo sapiens	Q15427	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	SF3B4	Homo sapiens	Q15427	Y2H Array	32296183
Intra	TFG	Q92734	HNRNPF	Homo sapiens	P52597	Y2H Prey Pooling	25416956
Intra	TFG	Q92734	TFG	Homo sapiens	Q92734	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	TFG	Homo sapiens	Q92734	Validated Y2H	32296183
Intra	TFG	Q92734	TFG	Homo sapiens	Q92734	Y2H Array	25416956
Intra	TFG	Q92734	TFG	Homo sapiens	Q92734	Y2H Pooling	16169070
Intra	TFG	Q92734	TFG	Homo sapiens	Q92734	BFG-2H	27107012
Intra	TFG	Q92734	TFG	Homo sapiens	Q92734	Y2H Array	32296183
Intra	TFG	Q92734	TFG	Homo sapiens	Q92734	Validated Y2H	27107012
Intra	TFG	Q92734	PFDN5	Homo sapiens	Q99471	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	PFDN5	Homo sapiens	Q99471	Validated Y2H	32296183
Intra	TFG	Q92734	PFDN5	Homo sapiens	Q99471	Y2H Array	32296183
Intra	TFG	Q92734	KRTAP26-1	Homo sapiens	Q6PEX3	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	KRTAP26-1	Homo sapiens	Q6PEX3	Y2H Array	32296183
Intra	TFG	Q92734	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	TFG	Q92734	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	CSTF2	Homo sapiens	P33240	Y2H Array	25416956
Intra	TFG	Q92734	CSTF2	Homo sapiens	P33240	Y2H Prey Pooling	25416956
Intra	TFG	Q92734	ANXA11	Homo sapiens	P50995	Y2H Array	31515488
Intra	TFG	Q92734	MAGED1	Homo sapiens	Q9Y5V3	Validated Y2H	32296183
Intra	TFG	Q92734	MAGED1	Homo sapiens	Q9Y5V3	Y2H Array	25416956
Intra	TFG	Q92734	MAGED1	Homo sapiens	Q9Y5V3	Y2H Array	32296183
Intra	TFG	Q92734	MAGED1	Homo sapiens	Q9Y5V3	Y2H Prey Pooling	25416956
Intra	TFG	Q92734	MAGED1	Homo sapiens	Q9Y5V3	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	MAGED1	Homo sapiens	Q9Y5V3	Validated Y2H	25416956
Intra	TFG	Q92734	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	DAZAP2	Homo sapiens	Q15038	Y2H Array	32296183
Intra	TFG	Q92734	PEF1	Homo sapiens	Q9UBV8	Validated Y2H	32296183
Intra	TFG	Q92734	PEF1	Homo sapiens	Q9UBV8	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	PEF1	Homo sapiens	Q9UBV8	Y2H Array	32296183
Intra	TFG	Q92734	PLA2G10	Homo sapiens	O15496	Y2H Array	32296183
Intra	TFG	Q92734	PLA2G10	Homo sapiens	O15496	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	LENG8	Homo sapiens	Q96PV6	Validated Y2H	32296183
Intra	TFG	Q92734	EWSR1	Homo sapiens	Q01844	Y2H Array	25416956
Intra	TFG	Q92734	DVL3	Homo sapiens	Q92997	Y2H Array	32296183
Intra	TFG	Q92734	DVL3	Homo sapiens	Q92997	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	DVL3	Homo sapiens	Q92997	Validated Y2H	32296183
Intra	TFG	Q92734	PLSCR1	Homo sapiens	O15162	Pull Down	16189514
Intra	TFG	Q92734	RBPMS	Homo sapiens	Q93062	Validated Y2H	25416956
Intra	TFG	Q92734	RBPMS	Homo sapiens	Q93062	Y2H Array	25416956
Intra	TFG	Q92734	MAPK1IP1L	Homo sapiens	Q8NDC0	Y2H Prey Pooling	25416956
Intra	TFG	Q92734	MAPK1IP1L	Homo sapiens	Q8NDC0	Validated Y2H	25416956
Intra	TFG	Q92734	MAPK1IP1L	Homo sapiens	Q8NDC0	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	MAPK1IP1L	Homo sapiens	Q8NDC0	Y2H Array	25416956
Intra	TFG	Q92734	MAPK1IP1L	Homo sapiens	Q8NDC0	Y2H Array	32296183
Intra	TFG	Q92734	SPG21	Homo sapiens	Q9NZD8	Validated Y2H	25416956
Intra	TFG	Q92734	SPG21	Homo sapiens	Q9NZD8	Y2H Array	25416956
Intra	TFG	Q92734	SPMIP9	Homo sapiens	Q96LM6	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	SPMIP9	Homo sapiens	Q96LM6	Validated Y2H	32296183
Intra	TFG	Q92734	SPMIP9	Homo sapiens	Q96LM6	Y2H Array	32296183
Intra	TFG	Q92734	CEP55	Homo sapiens	Q53EZ4	Y2H Array	32296183
Intra	TFG	Q92734	CEP55	Homo sapiens	Q53EZ4	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	CRX	Homo sapiens	O43186	Y2H Array	32296183
Intra	TFG	Q92734	CRX	Homo sapiens	O43186	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	INTS11	Homo sapiens	Q5TA45	Y2H Array	32296183
Intra	TFG	Q92734	INTS11	Homo sapiens	Q5TA45	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	NADSYN1	Homo sapiens	Q6IA69	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	NADSYN1	Homo sapiens	Q6IA69	Y2H Array	32296183
Intra	TFG	Q92734	SEC24A	Homo sapiens	O95486	Y2H Array	25416956
Intra	TFG	Q92734	SEC24A	Homo sapiens	O95486	Y2H Prey Pooling	25416956
Intra	TFG	Q92734	METTL27	Homo sapiens	Q8N6F8	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	METTL27	Homo sapiens	Q8N6F8	Y2H Array	32296183
Intra	TFG	Q92734	LASP1	Homo sapiens	Q14847-2	Y2H Array	32296183
Intra	TFG	Q92734	LASP1	Homo sapiens	Q14847-2	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	POU2AF1	Homo sapiens	Q16633	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	POU2AF1	Homo sapiens	Q16633	Y2H Array	32296183
Intra	TFG	Q92734	PLEKHG4	Homo sapiens	Q58EX7	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	PLEKHG4	Homo sapiens	Q58EX7	Y2H Array	32296183
Intra	TFG	Q92734	BPIFA1	Homo sapiens	Q9NP55	Validated Y2H	32296183
Intra	TFG	Q92734	BPIFA1	Homo sapiens	Q9NP55	Y2H Prey Pooling	32296183
Intra	TFG	Q92734	BPIFA1	Homo sapiens	Q9NP55	Y2H Array	32296183
Intra	TFG	Q92734	BOLL	Homo sapiens	Q8N9W6	Y2H Prey Pooling	25416956
Intra	TFG	Q92734	BOLL	Homo sapiens	Q8N9W6	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

TFG Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82536	TFG Antibody (YA2281)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Spastic Paraplegia 57, Autosomal Recessive

SPG57	Hereditary Spastic Paraplegia 57
Autosomal Recessive Spastic Paraplegia Type 57	Autosomal Recessive Spastic Paraplegia 57
Spastic Paraplegia Due To Partial Tfg Deficiency	Paraplegia, Spastic, Type 57, Autosomal Recessive

Neuropathy, Hereditary Motor And Sensory, Okinawa Type

Hereditary Motor And Sensory Neuropathy, Okinawa Type	HMSNO
Hereditary Motor And Sensory Neuropathy, Proximal Type	Hmsnp
Hereditary Motor And Sensory Neuropathy, Proximal Type, Formerly	Hmsnp, Formerly
Hereditary Motor And Sensory Neuropathy Okinawa	Neuropathy, Motor And Sensory, Hereditary, Okinawa Type

Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Tfg Mutation

Cmt2 Due To Tfg Mutation

Chondrosarcoma, Extraskeletal Myxoid

Extraskeletal Myxoid Chondrosarcoma	Emc
Myxoid Extraosseous Chondrosarcoma

Differentiated Thyroid Carcinoma

Papillary Or Follicular Thyroid Carcinoma	Well-Differentiated Thyroid Carcinoma
Differentiated Thyroid Gland Carcinoma

Charcot-Marie-Tooth Disease

Cmt	Hmsn
Hereditary Motor And Sensory Neuropathy	Pma
Cmt - Charcot-Marie-Tooth Disease	Charcot Marie Tooth Disease
Charcot-Marie-Tooth Hereditary Neuropathy	Charcot-Marie-Tooth Syndrome
Peroneal Muscular Atrophy	Hereditary Motor And Sensory Neuropathies

Anaplastic Large Cell Lymphoma

Alcl	Cd30 Positive Anaplastic Large Cell Lymphoma
Ki-1 Positive Anaplastic Large Cell Lymphoma	Primary Systemic Alcl
Sacl	Ki-1+ Anaplastic Large Cell Lymphoma

Chondrosarcoma

Cartilaginous Cancer	Chondrosarcoma Of Bone
Primary Chondrosarcoma Of The Bone	CHDSA

Occipital Lobe Neoplasm

Neoplasm Of Occipital Lobe	Malignant Neoplasm Of Occipital Lobe
Tumor Of Occipital Lobe

Paraplegia

Paraplegia, Lower

Severe Or Complete Loss Of Motor Function In The Lower Extremities And Lower Portions Of The Trunk

Lymphoma

Lymphoid Cancer	Lymphomas
Lymphoid Cancers	Lymphoid Neoplasm
Lymphoma Nos	Nhl - [Non-Hodgkin Lymphoma]
Non-Hodgkin Lymphoma	Non-Hodgkin Lymphoma, Nos
Non-Hodgkin Malignant Lymphoma Nos

Dental Fluorosis

Mottled Teeth	Intrinsic Enamel Discolouration Of Fluorosis
Mottling Of Enamel	Fluorosis, Dental
Dental Fluorosis, Acquired

Bone Chondrosarcoma

Spondylometaphyseal Dysplasia, Corner Fracture Type

SMDCF	Spondylometaphyseal Dysplasia, Sutcliffe Type
Spondylometaphyseal Dysplasia Corner Fracture Type	Spondylometaphyseal Dysplasia, 'Corner Fracture' Type
Spondylometaphyseal Dysplasia Sutcliffe Type	Sutcliffe Type Of Spondylometaphyseal Dysplasia
Spondylometaphyseal Dysplasia - Sutcliffe Type	Smd, Corner Fractures Type
Smd, Sutcliffe Type	Sutcliffe Smd
Dysplasia, Spondylometaphyseal, Corner Fracture Type

Inflammatory Myofibroblastic Tumor

Inflammatory Fibrosarcoma

Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive

Charcot-Marie-Tooth Disease Type 4	Charcot-Marie-Tooth Disease Type 4e
Hereditary Motor And Sensory Neuropathy	Cmt4e
CHN1	Hypomyelinating Neuropathy, Congenital, 1
Charcot-Marie-Tooth Neuropathy Type 4e	Neuropathy, Congenital Hypomyelinating, 1
Ar-Cmt1	Autosomal Recessive Demyelinating Charcot-Marie-Tooth
Cmt4	Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive
Hypomyelination, Severe Congenital	Charcot-Marie-Tooth Disease, Type 4e
Charcot-Marie-Tooth Neuropathy, Type 4e	Autosomal Recessive Congenital Hypomyelinating Or Amyelinating Neuropathy
Autosomal Recessive Congenital Hypomyelinating Neuropathy	Congenital Amyelinating Neuropathy
Congenital Hypomyelinating Neuropathy Autosomal Recessive	Neuropathy, Congenital Hypomyelinating Or Amyelinating
Severe Congenital Hypomyelination	Hereditary Sensory Motor Neuropathy
Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive	Neuropathy, Hypomyelinating, Congenital, Type 1
Neuropathy, Motor And Sensory, Hereditary	Congenital Hypomyelinating Neuropathy
Hereditary Motor And Sensory Neuropathies	Hereditary Sensorimotor Neuropathy
Hmsn - [Hereditary Motor And Sensory Neuropathy]	Hsmn - [Hereditary Sensory And Motor Neuropathy]
Hereditary Motor And Sensory Neuropathy, Types I-Iv

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia	Hereditary Spastic Paraparesis
Strumpell-Lorrain Disease	Familial Spastic Paraparesis
Hsp	Spg
Strümpell-Lorrain Disease	Spastic Paraplegia, Hereditary
French Settlement Disease	Strumpell-Lorrain Syndrome
Fsp	Spastic Paraplegia, Familial
Spastic Paraplegia Hereditary	Spastic Paraplegia 3, Autosomal Dominant
Spastic Paraparesis	Hereditary Spastic Paralysis
Familial Spastic Paralysis	Hereditary Spastic Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14425	TFG Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TFG	RGD	RGD:1309751
Macaca mulatta	TFG	VGNC	VGNC:82715
Canis familiaris	TFG	VGNC	VGNC:47299
Mus musculus	TFG	MGD	MGI:1338041
Felis catus	TFG	VGNC	VGNC:66122
Others	TFG	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.