PPP3CC - protein phosphatase 3 catalytic subunit gamma Gene

Homo sapiens

Also known as CNA3; CALNA3; PP2Bgamma

Gene ID: 5533 | Gene type: protein coding

About PPP3CC

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:22,441,078-22,541,125 (from NCBI)

This gene has 8 transcripts (splice variants), 211 orthologues and 12 paralogues. Broad expression in testis (RPKM 12.3), lymph node (RPKM 5.3) and 24 other tissues.

Summary

Calcineurin is a calcium-dependent, calmodulin-stimulated protein Phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for Calcineurin. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

PPP3CC Products(3)

mRNA	Protein	Name
NM_001243974.2	NP_001230903.1	serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 1
NM_001243975.2	NP_001230904.1	serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 3
NM_005605.5	NP_005596.2	serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium-dependent protein serine/threonine phosphatase activity	IDA IDA: Inferred from direct assay	26429887	GOA
enables calmodulin-dependent protein phosphatase activity	IDA IDA: Inferred from direct assay	19154138	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in calcineurin-NFAT signaling cascade	IDA IDA: Inferred from direct assay	19154138	GOA
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	19154138	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19154138	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP3CC Protein Structure

Metallophos

0
100
200
300
400
512 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

CAM-PRP catalytic subunit

PPP3CC Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PPP3CC	P48454	SPATA33	Homo sapiens	Q96N06	Validated Y2H	32296183
Intra	PPP3CC	P48454	UNC119	Homo sapiens	Q13432	Validated Y2H	32296183
Intra	PPP3CC	P48454	AMPH	Homo sapiens	P49418	Y2H Array	25416956
Intra	PPP3CC	P48454	AMPH	Homo sapiens	P49418	Validated Y2H	25416956
Intra	PPP3CC	P48454	PPP3R1	Homo sapiens	P63098	Anti Tag CoIP	28514442
Intra	PPP3CC	P48454	PPP3R1	Homo sapiens	P63098	Validated Y2H	32296183
Intra	PPP3CC	P48454	PPP3R1	Homo sapiens	P63098	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Melancholia

Schizophrenia 11

Sczd11

Schizophrenia Susceptibility Locus, Chromosome 10q-Related

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Schizophrenia 6

SCZD6	Schizophrenia Susceptibility Locus, Chromosome 8p-Related
Schizophrenia, Type 6

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11025	PPP3CC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PPP3CC	VGNC	VGNC:69021
Rattus norvegicus	PPP3CC	RGD	RGD:621616
Mus musculus	PPP3CC	MGD	MGI:107162
Canis familiaris	PPP3CC	VGNC	VGNC:44920
Macaca mulatta	PPP3CC	VGNC	VGNC:76383
Bos taurus	PPP3CC	VGNC	VGNC:33267

Name
Email *

	Sorry, but the email address you supplied was invalid.