2. Gene
  3. PPP3CC - protein phosphatase 3 catalytic subunit gamma Gene

PPP3CC - protein phosphatase 3 catalytic subunit gamma Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CNA3; CALNA3; PP2Bgamma

Gene ID: 5533 | Gene type: protein coding

About PPP3CC

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:22,441,078-22,541,125 (from NCBI)

This gene has 8 transcripts (splice variants), 211 orthologues and 12 paralogues. Broad expression in testis (RPKM 12.3), lymph node (RPKM 5.3) and 24 other tissues.

Summary

Calcineurin is a calcium-dependent, calmodulin-stimulated protein Phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for Calcineurin. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

PPP3CC Products(3)

mRNA Protein Name
NM_001243974.2 NP_001230903.1 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 1
NM_001243975.2 NP_001230904.1 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 3
NM_005605.5 NP_005596.2 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 2

PPP3CC Protein Structure

Metallophos

Metallophos: Calcineurin-like phosphoesterase (80 - 280)

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  • 512 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

CAM-PRP catalytic subunit

Related Diseases

Diseases Alias
Melancholia
Schizophrenia 11

Sczd11

Schizophrenia Susceptibility Locus, Chromosome 10q-Related
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Schizophrenia 6

SCZD6

Schizophrenia Susceptibility Locus, Chromosome 8p-Related

Schizophrenia, Type 6
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11025 PPP3CC Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PPP3CC VGNC VGNC:69021
Rattus norvegicus PPP3CC RGD RGD:621616
Mus musculus PPP3CC MGD MGI:107162
Canis familiaris PPP3CC VGNC VGNC:44920
Macaca mulatta PPP3CC VGNC VGNC:76383
Bos taurus PPP3CC VGNC VGNC:33267