SIRPG - signal regulatory protein gamma Gene

Homo sapiens

Also known as CD172g; SIRPB2; SIRP-B2; bA77C3.1; SIRPgamma

Gene ID: 55423 | Gene type: protein coding

About SIRPG

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:1,629,152-1,686,455 (from NCBI)

This gene has 7 transcripts (splice variants), 281 orthologues and 4 paralogues. Biased expression in lymph node (RPKM 13.6), appendix (RPKM 6.0) and 8 other tissues.

Summary

The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

SIRPG Products(3)

mRNA	Protein	Name
NM_001039508.2	NP_001034597.1	signal-regulatory protein gamma isoform 3 precursor
NM_018556.4	NP_061026.2	signal-regulatory protein gamma isoform 1 precursor
NM_080816.3	NP_543006.2	signal-regulatory protein gamma isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15383453	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of T cell activation	IDA IDA: Inferred from direct assay	15383453	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	15383453	GOA
involved in positive regulation of cell-cell adhesion	IDA IDA: Inferred from direct assay	15383453	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	15383453	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIRPG Protein Structure

V-set

C1-set

0
100
200
300
387 a.a.

Protein Preferred Names

Protein Names

signal-regulatory protein gamma

CD172 antigen-like family member B

SIRPG Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SIRPG	Q9P1W8	CD47	Homo sapiens	Q08722	FACS	15383453
Intra	SIRPG	Q9P1W8	GATM	Homo sapiens	P50440	Y2H Array	32814053
Intra	SIRPG	Q9P1W8	GATM	Homo sapiens	P50440	Validated Y2H	32814053
Intra	SIRPG	Q9P1W8	GATM	Homo sapiens	P50440	Y2H Pooling	32814053
Intra	SIRPG	Q9P1W8	FOS	Homo sapiens	P01100	Validated Y2H	32814053
Intra	SIRPG	Q9P1W8	FOS	Homo sapiens	P01100	Y2H Array	32814053
Intra	SIRPG	Q9P1W8	FOS	Homo sapiens	P01100	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SIRPG Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71316	SIRP gamma Protein, Human (HEK293, Fc)	Q9P1W8-1(E29-P360)	≥95%
HY-P78210	SIRP gamma Protein, Human (Biotinylated, HEK293, His-Avi)	Q9P1W8-1 (E29-P360)	≥95%
HY-P78521	SIRP gamma Protein, Human (HEK293, His-Avi)	Q9P1W8-1 (E29-P360)	≥95%

Related Diseases

Diseases

Alias

Hemolytic Disease Of Fetus And Newborn, Rh-Induced

Rh Deficiency Syndrome	Rh Disease
HDFNRH	Rh Fetomaternal Incompatibility
Rh-Null Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12936	SIRPG Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca fascicularis	SIRPG	NCBI
Others	SIRPG	NCBI

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