GPRC5D - G protein-coupled receptor class C group 5 member D Gene

Homo sapiens

Gene ID: 55507 | Gene type: protein coding

About GPRC5D

Cytogenetic location: 12p13.1 Genomic coordinates (GRCh38): 12:12,940,575-12,952,170 (from NCBI)

This gene has 2 transcripts (splice variants), 197 orthologues and 3 paralogues. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a member of the G protein-coupled receptor family; however, the specific function of this gene has not yet been determined. [provided by RefSeq, Jul 2008]

GPRC5D Products(1)

mRNA	Protein	Name
NM_018654.2	NP_061124.1	G-protein coupled receptor family C group 5 member D

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPRC5D Protein Structure

7tm_3

0
100
200
300
345 a.a.

Protein Preferred Names

Protein Names

G-protein coupled receptor family C group 5 member D

orphan G-protein coupled receptor

GPRC5D Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GPRC5D	Q9NZD1	LRRC25	Homo sapiens	Q8N386	Y2H Array	32296183
Intra	GPRC5D	Q9NZD1	LRRC25	Homo sapiens	Q8N386	Y2H Prey Pooling	32296183
Intra	GPRC5D	Q9NZD1	LHFPL5	Homo sapiens	Q8TAF8	Y2H Prey Pooling	32296183
Intra	GPRC5D	Q9NZD1	PVR	Homo sapiens	P15151	Y2H Array	32296183
Intra	GPRC5D	Q9NZD1	PVR	Homo sapiens	P15151	Y2H Prey Pooling	32296183
Intra	GPRC5D	Q9NZD1	SYNDIG1	Homo sapiens	Q9H7V2	Y2H Prey Pooling	32296183
Intra	GPRC5D	Q9NZD1	SYNDIG1	Homo sapiens	Q9H7V2	Y2H Array	32296183
Intra	GPRC5D	Q9NZD1	YIPF1	Homo sapiens	Q9Y548	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GPRC5D Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77958	GPRC5D Protein-VLP, Human (HEK293)	Q9NZD1-1 (M1-V345)	≥95%
HY-P77959	GPRC5D Protein-VLP, Human (Biotinylated, HEK293)	Q9NZD1-1 (M1-V345)	≥95%
HY-P700457	GPRC5D Protein-VLP, Human (HEK293, C-His)	Q9NZD1-1 (M1-V345)	≥95%

Related Diseases

Diseases

Alias

Smoldering Myeloma

Keratopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99394	Talquetamab		98.52%	Unkown

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05752	GPRC5D Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GPRC5D	VGNC	VGNC:41451
Felis catus	GPRC5D	VGNC	VGNC:62695
Macaca mulatta	GPRC5D	VGNC	VGNC:72935
Bos taurus	GPRC5D	VGNC	VGNC:29608
Mus musculus	GPRC5D	MGD	MGI:1935037
Rattus norvegicus	GPRC5D	RGD	RGD:1563887
Macaca fascicularis	GPRC5D	NCBI	NCBI:102122120
Others	GPRC5D	NCBI

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