SYNDIG1 - synapse differentiation inducing 1 Gene

Homo sapiens

Also known as DSPC2; IFITMD5; TMEM90B; C20orf39

Gene ID: 79953 | Gene type: protein coding

About SYNDIG1

Cytogenetic location: 20p11.21 Genomic coordinates (GRCh38): 20:24,469,629-24,666,616 (from NCBI)

This gene has 2 transcripts (splice variants), 192 orthologues and 3 paralogues. Biased expression in brain (RPKM 1.9), heart (RPKM 1.6) and 11 other tissues.

Summary

This gene encodes a protein that belongs to the interferon-induced transmembrane family of proteins. A similar protein in rat is thought to regulate the development of excitatory synapses. [provided by RefSeq, Jul 2013]

SYNDIG1 Products(3)

mRNA	Protein	Name
NM_001323606.2	NP_001310535.1	synapse differentiation-inducing gene protein 1
NM_001323607.2	NP_001310536.1	synapse differentiation-inducing gene protein 1
NM_024893.3	NP_079169.1	synapse differentiation-inducing gene protein 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of synapse assembly	IDA IDA: Inferred from direct assay	20152115	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SYNDIG1 Protein Structure

CD225

0
100
200
258 a.a.

Protein Preferred Names

Protein Names

synapse differentiation-inducing gene protein 1

dispanin subfamily C member 2

SYNDIG1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SYNDIG1	Q9H7V2	SLC16A13	Homo sapiens	Q7RTY0	Y2H Array	32296183
Intra	SYNDIG1	Q9H7V2	SLC16A13	Homo sapiens	Q7RTY0	Y2H Prey Pooling	32296183
Intra	SYNDIG1	Q9H7V2	TLCD4	Homo sapiens	Q96MV1	Y2H Array	32296183
Intra	SYNDIG1	Q9H7V2	TLCD4	Homo sapiens	Q96MV1	Y2H Prey Pooling	32296183
Intra	SYNDIG1	Q9H7V2	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	SYNDIG1	Q9H7V2	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	SYNDIG1	Q9H7V2	GPRC5D	Homo sapiens	Q9NZD1	Validated Y2H	32296183
Intra	SYNDIG1	Q9H7V2	SLC35C2	Homo sapiens	Q9NQQ7-3	Validated Y2H	32296183
Intra	SYNDIG1	Q9H7V2	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Prey Pooling	32296183
Intra	SYNDIG1	Q9H7V2	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Array	32296183
Intra	SYNDIG1	Q9H7V2	GPR42	Homo sapiens	O15529	Y2H Array	32296183
Intra	SYNDIG1	Q9H7V2	GPR42	Homo sapiens	O15529	Y2H Prey Pooling	32296183
Intra	SYNDIG1	Q9H7V2	ELOVL4	Homo sapiens	Q9GZR5	Y2H Prey Pooling	32296183
Intra	SYNDIG1	Q9H7V2	ELOVL4	Homo sapiens	Q9GZR5	Y2H Array	32296183
Intra	SYNDIG1	Q9H7V2	FFAR2	Homo sapiens	O15552	Y2H Array	32296183
Intra	SYNDIG1	Q9H7V2	FFAR2	Homo sapiens	O15552	Y2H Prey Pooling	32296183
Intra	SYNDIG1	Q9H7V2	FATE1	Homo sapiens	Q969F0	Y2H Prey Pooling	32296183
Intra	SYNDIG1	Q9H7V2	FATE1	Homo sapiens	Q969F0	Y2H Array	32296183
Intra	SYNDIG1	Q9H7V2	FATE1	Homo sapiens	Q969F0	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Osteogenesis Imperfecta, Type V

Osteogenesis Imperfecta Type 5	OI5
Osteogenesis Imperfecta Type V	Oi Type 5
Oi Type V	Oi, Type V
Oi With Calcification In Interosseous Membranes	Type V Oi
Osteogenesis Imperfecta 5	Oi-V

Gliofibroma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14083	SYNDIG1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14084	SYNDIG1L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SYNDIG1	VGNC	VGNC:35519
Macaca mulatta	SYNDIG1	VGNC	VGNC:78130
Rattus norvegicus	SYNDIG1	RGD	RGD:1310753
Felis catus	SYNDIG1	VGNC	VGNC:81233
Canis familiaris	SYNDIG1	VGNC	VGNC:47025
Mus musculus	SYNDIG1	MGD	MGI:3702158

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