PRG2 - proteoglycan 2, pro eosinophil major basic protein Gene

Homo sapiens

Also known as MBP; BMPG; MBP1; proMBP

Gene ID: 5553 | Gene type: protein coding

About PRG2

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:57,386,780-57,390,650 (from NCBI)

This gene has 4 transcripts (splice variants), 98 orthologues and 1 paralogue. Restricted expression toward placenta (RPKM 1164.9).

Summary

The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several Other proteins including pregnancy-associated plasma protein A (PAPPA), Angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]

PRG2 Products(4)

mRNA	Protein	Name
NM_001243245.3	NP_001230174.1	bone marrow proteoglycan isoform 2 preproprotein
NM_001302926.2	NP_001289855.1	bone marrow proteoglycan isoform 1 preproprotein
NM_001302927.2	NP_001289856.1	bone marrow proteoglycan isoform 1 preproprotein
NM_002728.6	NP_002719.3	bone marrow proteoglycan isoform 1 preproprotein

PRG2 Protein Structure

Lectin_C

0
100
200
222 a.a.

Protein Preferred Names

Protein Names

bone marrow proteoglycan

eosinophil granule major basic protein

PRG2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PRG2	P13727	PAPPA	Homo sapiens	Q13219	GMS	12421832
Intra	PRG2	P13727	PAPPA	Homo sapiens	Q13219	Chromatography	7685339

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PRG2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7672	BMPG Protein, Human (HEK293, His)	AAH05929.1 (L17-Y222 )	≥95%

Related Diseases

Diseases

Alias

Hypereosinophilic Syndrome

Eosinophilia	HES
Eosinophilic Leukocytosis	Hypereosinophilic Syndrome, Idiopathic
Idiopathic Hypereosinophilic Syndrome	Disseminated Eosinophilic Collagen Disease
Eosinophilic Disorder	Disorders With Increased Eosinophil Counts

Dermatographia

Dermatographic Urticaria	Dermographism
Symptomatic Dermographism	Urticaria Factitia
Factitious Urticaria	Dermatographism

Conidiobolomycosis

Infection By Conidiobolus	Rhinoentomophthoromycosis
Entomophthoromycosis Conidiobolae

Esophagitis

Acute Esophagitis

Churg-Strauss Syndrome

Eosinophilic Granulomatosis With Polyangiitis	Allergic Granulomatous Angiitis
Churg-Strauss Vasculitis	Allergic Angiitis
Egpa	Granulomatous Allergic Angiitis
Allergic Granulomatosis Angiitis	Allergic Angiitis And Granulomatosis
Allergic Granulomatosis	Allergic Granulomatous And Angiitis
Css

Urticaria

Nettle Rash	Hives
Wheal	Urticaria Nos

Rhinitis

Runny Nose

Colon Sarcoma

Colonic Sarcoma

Loeffler Endocarditis

Eosinophilic Endomyocardial Disease	Eosinophilic Endocarditis
Loeffler'S Endocarditis	Primary Eosinophilic Endomyocardial Restrictive Cardiomyopathy

Pulmonary Eosinophilia

Asthmatic Pulmonary Eosinophilia	Eosinophilic Lung Infiltrate
Weingarten'S Syndrome

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Gastroenteritis

Cholera Morbus	Infectious Colitis, Enteritis And Gastroenteritis
Enteritis Due To Astrovirus	Rotaviral Gastroenteritis
Viral Gastroenteritis Due To Rotavirus

Schizophrenia 13

SCZD13	Schizophrenia Susceptibility Locus, Chromosome 15q13-Q14-Related
Schizophrenia, Susceptibility To, 13

Loeffler Syndrome

Loeffler'S Pneumonia	Loffler'S Syndrome
Simple Pulmonary Eosinophilia

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Endomyocardial Fibrosis

Becker'S Disease	Obscure African Cardiomyopathy
African Endomyocardial Fibrosis	Endomyocardial Sclerosis
EMF	Becker Muscular Dystrophy

Myiasis

Infestation By Fly Larvae	Infestation By Maggots
Maggot Infestation	Infestation By Larvae Of Flies
Infestation By Dermatobia	Infestation By Estrus Ovis
Infestation By Oestrus Ovis	Oestriasis
Oestrosis

Esophagitis, Eosinophilic, 1

Eosinophilic Esophagitis	EOE1
Esophagitis, Eosinophilic	Ee

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11088	PRG2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PRG2	MGD	MGI:103294
Rattus norvegicus	PRG2	RGD	RGD:69336

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