RBM38 - RNA binding motif protein 38 Gene

Homo sapiens

Also known as RNPC1; SEB4B; SEB4D; HSRNASEB; dJ800J21.2

Gene ID: 55544 | Gene type: protein coding

About RBM38

Cytogenetic location: 20q13.31 Genomic coordinates (GRCh38): 20:57,391,396-57,409,333 (from NCBI)

This gene has 5 transcripts (splice variants), 247 orthologues and 24 paralogues. Broad expression in bone marrow (RPKM 68.1), lymph node (RPKM 23.9) and 18 other tissues.

Summary

Enables mRNA 3'-UTR binding activity. Involved in DNA damage response, signal transduction by p53 class mediator; negative regulation of cell population proliferation; and regulation of RNA metabolic process. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

RBM38 Products(3)

mRNA	Protein	Name
NM_001291780.2	NP_001278709.1	RNA-binding protein 38 isoform c
NM_017495.6	NP_059965.2	RNA-binding protein 38 isoform a
NM_183425.3	NP_906270.1	RNA-binding protein 38 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	17050675	GOA
enables mRNA binding	IDA IDA: Inferred from direct assay	17050675	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in 3'-UTR-mediated mRNA stabilization	IDA IDA: Inferred from direct assay	17050675	GOA
involved in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	IDA IDA: Inferred from direct assay	17050675	GOA
involved in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	IDA IDA: Inferred from direct assay	17050675	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	17050675	GOA
involved in regulation of RNA splicing	IDA IDA: Inferred from direct assay	19285943	GOA
NOT involved in regulation of cell cycle	IDA IDA: Inferred from direct assay	17050675	GOA
involved in regulation of cell cycle	IDA IDA: Inferred from direct assay	17050675	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	17050675	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17050675	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBM38 Protein Structure

RRM_1

0
100
200
239 a.a.

Protein Preferred Names

Protein Names

RNA-binding protein 38

CLL-associated antigen KW-5

Related Diseases

Diseases

Alias

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Erythema Infectiosum

Fifth Disease	Slapped Cheek Syndrome
Parvovirus B19 Infection

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11750	RBM38 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RBM38	RGD	RGD:1308503
Macaca mulatta	RBM38	VGNC	VGNC:76484
Mus musculus	RBM38	MGD	MGI:1889294
Canis familiaris	RBM38	VGNC	VGNC:54726
Bos taurus	RBM38	VGNC	VGNC:33798
Others	RBM38	NCBI

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