2. Gene
  3. PPP1R9A - protein phosphatase 1 regulatory subunit 9A Gene

PPP1R9A - protein phosphatase 1 regulatory subunit 9A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as NRB1; NRBI; Neurabin-I

Gene ID: 55607 | Gene type: protein coding

About PPP1R9A

Cytogenetic location: 7q21.3 Genomic coordinates (GRCh38): 7:94,907,236-95,296,415 (from NCBI)

This gene has 8 transcripts (splice variants), 214 orthologues and 2 paralogues. Broad expression in brain (RPKM 4.9), adrenal (RPKM 2.5) and 21 other tissues.

Summary

This gene is imprinted, and located in a cluster of imprinted genes on chromosome 7q12. This gene is transcribed in both neuronal and multiple embryonic tissues, and it is maternally expressed mainly in embryonic skeletal muscle tissues and biallelically expressed in Other embryonic tissues. The protein encoded by this gene includes a PDZ domain and a sterile alpha motif (SAM). It is a regulatory subunit of protein Phosphatase I, and controls actin Cytoskeleton reorganization. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

PPP1R9A Products(5)

mRNA Protein Name
NM_001166160.2 NP_001159632.1 neurabin-1 isoform 1
NM_001166161.1 NP_001159633.1 neurabin-1 isoform 2
NM_001166162.1 NP_001159634.1 neurabin-1 isoform 3
NM_001166163.1 NP_001159635.1 neurabin-1 isoform 5
NM_017650.3 NP_060120.2 neurabin-1 isoform 4
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
17464283 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP1R9A Protein Structure

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (507 - 588)

SAM_2

SAM_2: SAM domain (Sterile alpha motif) (987 - 1049)

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  • 1000
  • 1098 a.a.
Protein Preferred Names Protein Names

neurabin-1

neural tissue-specific F-actin-binding protein I

PPP1R9A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PPP1R9A Q9ULJ8 RGS2 Homo sapiens P41220
Pull Down
17464283
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11005 PPP1R9A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PPP1R9A VGNC VGNC:44902
Felis catus PPP1R9A VGNC VGNC:64326
Mus musculus PPP1R9A MGD MGI:2442401
Macaca mulatta PPP1R9A VGNC VGNC:76258
Rattus norvegicus PPP1R9A RGD RGD:632280
Bos taurus PPP1R9A VGNC VGNC:33250