PRR5 - proline rich 5 Gene

Homo sapiens

Also known as PP610; PROTOR1; PROTOR-1; FLJ20185k

Gene ID: 55615 | Gene type: protein coding

About PRR5

Cytogenetic location: 22q13.31 Genomic coordinates (GRCh38): 22:44,668,751-44,737,681 (from NCBI)

This gene has 18 transcripts (splice variants), 255 orthologues and 1 paralogue. Broad expression in fat (RPKM 9.7), spleen (RPKM 8.6) and 23 other tissues.

Summary

This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010]

PRR5 Products(6)

mRNA	Protein	Name
NM_001017528.3	NP_001017528.1	proline-rich protein 5 isoform 2
NM_001017529.3	NP_001017529.1	proline-rich protein 5 isoform 3
NM_001017530.2	NP_001017530.1	proline-rich protein 5 isoform 3
NM_001198721.2	NP_001185650.1	proline-rich protein 5 isoform 4
NM_015366.4	NP_056181.2	proline-rich protein 5 isoform 2
NM_181333.4	NP_851850.1	proline-rich protein 5 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24550280	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of TORC2 complex	IDA IDA: Inferred from direct assay	22609986	GOA
part of TORC2 complex	IPI IPI: Inferred from physical interaction	17461779	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRR5 Protein Structure

HbrB

0
100
200
300
388 a.a.

Protein Preferred Names

Protein Names

proline-rich protein 5

Rho GTPase activating protein 8

PRR5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PRR5	P85299	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	33961781
Intra	PRR5	P85299	DLG1	Homo sapiens	Q12959	Phage Display	24550280

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Endocervicitis

Dravet Syndrome

Severe Myoclonic Epilepsy Of Infancy	Severe Myoclonic Epilepsy In Infancy
Smei	Epileptic Encephalopathy, Early Infantile, 6
DRVT	Developmental And Epileptic Encephalopathy 6a
Dee6a	Eiee6
Developmental And Epileptic Encephalopathy, 6	Dee6
Developmental And Epileptic Encephalopathy 6	Early Infantile Epileptic Encephalopathy 6
Myoclonic Epilepsy, Severe, Of Infancy	Sme
Severe Myoclonus Epilepsy Of Infancy	Borderline Smei
Smeb	Smeb-M
Smeb-O	Smeb-Sw
Smei-Borderland	Smei-Borderland More Than One Feature
Smei-Borderland-Myoclonic Seizures	Smei-Borderland-Spike Wave
Intractable Childhood Epilepsy With Generalized Tonic-Clonic Seizures	ICEGTC
Infantile Severe Myoclonic Epilepsy	Epilepsy, Intractable Childhood, With Generalized Tonic-Clonic Seizures

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11232	PRR5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PRR5	VGNC	VGNC:107920
Mus musculus	PRR5	MGD	MGI:1924714
Rattus norvegicus	PRR5	RGD	RGD:1307954
Felis catus	PRR5	VGNC	VGNC:64387
Bos taurus	PRR5	VGNC	VGNC:33400
Canis familiaris	PRR5	VGNC	VGNC:45047

Name
Email *

	Sorry, but the email address you supplied was invalid.