KDM4D - lysine demethylase 4D Gene

Homo sapiens

Also known as JMJD2D

Gene ID: 55693 | Gene type: protein coding

About KDM4D

Cytogenetic location: 11q21 Genomic coordinates (GRCh38): 11:94,973,709-94,999,519 (from NCBI)

This gene has 3 transcripts (splice variants), 207 orthologues and 10 paralogues. Biased expression in testis (RPKM 26.3) and brain (RPKM 0.6).

Summary

Enables histone H3-methyl-lysine-9 demethylase activity. Involved in histone H3-K9 demethylation. Acts upstream of or within several processes, including cellular response to ionizing radiation; positive regulation of chromatin binding activity; and positive regulation of double-strand break repair via nonhomologous end joining. Located in site of double-strand break. Biomarker of nephroblastoma. [provided by Alliance of Genome Resources, Apr 2022]

KDM4D Products(1)

mRNA	Protein	Name
NM_018039.3	NP_060509.2	lysine-specific demethylase 4D

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables histone H3K9 demethylase activity	IDA IDA: Inferred from direct assay	25124442	GOA
enables histone H3K9me2/H3K9me3 demethylase activity	IDA IDA: Inferred from direct assay	21914792	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular response to ionizing radiation	IMP IMP: Inferred from mutant phenotype	24550317	GOA
acts upstream of or within double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	24550317	GOA
involved in inflammatory response	IDA IDA: Inferred from direct assay	21914792	GOA
acts upstream of or within positive regulation of chromatin binding	IMP IMP: Inferred from mutant phenotype	24550317	GOA
acts upstream of or within positive regulation of double-strand break repair via nonhomologous end joining	IMP IMP: Inferred from mutant phenotype	24550317	GOA
acts upstream of or within regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	24550317	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in site of double-strand break	IDA IDA: Inferred from direct assay	24550317	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KDM4D Protein Structure

JmjN

JmjC

0
100
200
300
400
523 a.a.

Protein Preferred Names

Protein Names

lysine-specific demethylase 4D

[histone H3]-trimethyl-L-lysine(9) demethylase 4D

KDM4D Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KDM4D	Q6B0I6	CEP76	Homo sapiens	Q8TAP6	Y2H Prey Pooling	32296183
Intra	KDM4D	Q6B0I6	CEP76	Homo sapiens	Q8TAP6	Validated Y2H	32296183
Intra	KDM4D	Q6B0I6	CEP76	Homo sapiens	Q8TAP6	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-104048	QC6352	Inhibitor	99.48%	Unkown
HY-101928	KDM4D-IN-1	Inhibitor	99.95%	Unkown
HY-148807	Zavondemstat	Inhibitor	95.03%	Unkown
HY-148807A	Zavondemstat L-lysine	Inhibitor	/	Unkown
HY-RS07216	KDM4D Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-148807B	(S)-Zavondemstat		/	Unkown
HY-157408	KDM4D-IN-3		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KDM4D	MGD	MGI:3606484
Rattus norvegicus	KDM4D	RGD	RGD:1591045
Macaca mulatta	KDM4D	VGNC	VGNC:73908
Others	KDM4D	NCBI

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