2. Gene
  3. KDM4D - lysine demethylase 4D Gene

KDM4D - lysine demethylase 4D Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as JMJD2D

Gene ID: 55693 | Gene type: protein coding

About KDM4D

Cytogenetic location: 11q21 Genomic coordinates (GRCh38): 11:94,973,709-94,999,519 (from NCBI)

This gene has 3 transcripts (splice variants), 207 orthologues and 10 paralogues. Biased expression in testis (RPKM 26.3) and brain (RPKM 0.6).

Summary

Enables histone H3-methyl-lysine-9 demethylase activity. Involved in histone H3-K9 demethylation. Acts upstream of or within several processes, including cellular response to ionizing radiation; positive regulation of chromatin binding activity; and positive regulation of double-strand break repair via nonhomologous end joining. Located in site of double-strand break. Biomarker of nephroblastoma. [provided by Alliance of Genome Resources, Apr 2022]

KDM4D Products(1)

mRNA Protein Name
NM_018039.3 NP_060509.2 lysine-specific demethylase 4D
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables histone H3K9 demethylase activity IDA
IDA: Inferred from direct assay
25124442 GOA
enables histone H3K9me2/H3K9me3 demethylase activity IDA
IDA: Inferred from direct assay
21914792 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cellular response to ionizing radiation IMP
IMP: Inferred from mutant phenotype
24550317 GOA
acts upstream of or within double-strand break repair via homologous recombination IMP
IMP: Inferred from mutant phenotype
24550317 GOA
involved in inflammatory response IDA
IDA: Inferred from direct assay
21914792 GOA
acts upstream of or within positive regulation of chromatin binding IMP
IMP: Inferred from mutant phenotype
24550317 GOA
acts upstream of or within positive regulation of double-strand break repair via nonhomologous end joining IMP
IMP: Inferred from mutant phenotype
24550317 GOA
acts upstream of or within regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
24550317 GOA
Cellular Component GO Annotation Evidence Reference Source
located in site of double-strand break IDA
IDA: Inferred from direct assay
24550317 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KDM4D Protein Structure

JmjN

JmjN: jmjN domain (19 - 53)

JmjC

JmjC: JmjC domain, hydroxylase (179 - 295)

  • 0
  • 100
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  • 400
  • 523 a.a.
Protein Preferred Names Protein Names

lysine-specific demethylase 4D

[histone H3]-trimethyl-L-lysine(9) demethylase 4D

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-104048 QC6352 Inhibitor 99.48% Unkown
HY-101928 KDM4D-IN-1 Inhibitor 99.95% Unkown
HY-148807 Zavondemstat Inhibitor 95.03% Unkown
HY-148807A Zavondemstat L-lysine Inhibitor / Unkown
HY-RS07216 KDM4D Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-157408 KDM4D-IN-3 / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus KDM4D MGD MGI:3606484
Rattus norvegicus KDM4D RGD RGD:1591045
Macaca mulatta KDM4D VGNC VGNC:73908
Others KDM4D NCBI