DNAJC11 - DnaJ heat shock protein family (Hsp40) member C11 Gene

Homo sapiens

Also known as dJ126A5.1

Gene ID: 55735 | Gene type: protein coding

About DNAJC11

Cytogenetic location: 1p36.31 Genomic coordinates (GRCh38): 1:6,634,170-6,701,816 (from NCBI)

This gene has 25 transcripts (splice variants), 281 orthologues and 20 paralogues. Ubiquitous expression in kidney (RPKM 23.0), colon (RPKM 15.3) and 25 other tissues.

Summary

Involved in cristae formation. Located in mitochondrial outer membrane and nuclear speck. Part of MIB complex. Colocalizes with MICOS complex and SAM complex. [provided by Alliance of Genome Resources, Apr 2022]

DNAJC11 Products(1)

mRNA	Protein	Name
NM_018198.4	NP_060668.2	dnaJ homolog subfamily C member 11

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17500595	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cristae formation	IMP IMP: Inferred from mutant phenotype	25111180	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of MICOS complex	IDA IDA: Inferred from direct assay	25997101	GOA
part of SAM complex	IDA IDA: Inferred from direct assay	25997101	GOA
located in mitochondrial outer membrane	IMP IMP: Inferred from mutant phenotype	25111180	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	25997101	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DNAJC11 Protein Structure

DnaJ

DUF3395

0
100
200
300
400
500
559 a.a.

Protein Preferred Names

Protein Names

dnaJ homolog subfamily C member 11

DnaJ (Hsp40) homolog, subfamily C, member 11

DNAJC11 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DNAJC11	Q9NVH1	PM20D2	Homo sapiens	Q8IYS1	Y2H Array	32296183
Intra	DNAJC11	Q9NVH1	PM20D2	Homo sapiens	Q8IYS1	Y2H Prey Pooling	32296183
Intra	DNAJC11	Q9NVH1	VPS52	Homo sapiens	Q8N1B4	Y2H Prey Pooling	32296183
Intra	DNAJC11	Q9NVH1	VPS52	Homo sapiens	Q8N1B4	Y2H Array	32296183
Intra	DNAJC11	Q9NVH1	HTT	Homo sapiens	P42858	Y2H	17500595

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Seckel Syndrome 6

SCKL6

Seckel Syndrome, Type 6

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03874	DNAJC11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DNAJC11	VGNC	VGNC:99893
Canis familiaris	DNAJC11	VGNC	VGNC:53345
Rattus norvegicus	DNAJC11	RGD	RGD:1307731
Mus musculus	DNAJC11	MGD	MGI:2443386
Felis catus	DNAJC11	VGNC	VGNC:80185

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