FGD6 - FYVE, RhoGEF and PH domain containing 6 Gene

Homo sapiens

Also known as ZFYVE24

Gene ID: 55785 | Gene type: protein coding

About FGD6

Cytogenetic location: 12q22 Genomic coordinates (GRCh38): 12:95,076,749-95,217,467 (from NCBI)

This gene has 7 transcripts (splice variants), 263 orthologues and 10 paralogues. Ubiquitous expression in skin (RPKM 3.9), gall bladder (RPKM 3.5) and 25 other tissues.

Summary

Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in several processes, including filopodium assembly; regulation of GTPase activity; and regulation of cell shape. Predicted to be located in Golgi apparatus; lamellipodium; and ruffle. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

FGD6 Products(1)

mRNA	Protein	Name
NM_018351.4	NP_060821.3	FYVE, RhoGEF and PH domain-containing protein 6

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FGD6 Protein Structure

RhoGEF

FYVE

0
300
600
900
1200
1430 a.a.

Protein Preferred Names

Protein Names

FYVE, RhoGEF and PH domain-containing protein 6

zinc finger FYVE domain-containing protein 24

FGD6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FGD6	Q6ZV73	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Aarskog-Scott Syndrome

Aarskog Syndrome	Faciogenital Dysplasia
Faciodigitogenital Syndrome	AAS
Fgdy	X-Linked Aarskog Syndrome
Intellectual Developmental Disorder, X-Linked, Syndromic 16	Aarskog Syndrome, X-Linked
Intellectual Developmental Disorder, X-Linked Syndromic 16	Greig'S Syndrome
Aarskog Scott Syndrome	Aarskog Disease
Scott Aarskog Syndrome	Facio-Digito-Genital Dysplasia
Faciogenital Dysplasia With Attention Deficit-Hyperactivity Disorder	Aarskog-Scott Syndrome ) Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04885	FGD6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	FGD6	VGNC	VGNC:72548
Bos taurus	FGD6	VGNC	VGNC:28969
Felis catus	FGD6	VGNC	VGNC:62244
Mus musculus	FGD6	MGD	MGI:1261419
Canis familiaris	FGD6	VGNC	VGNC:40838
Rattus norvegicus	FGD6	RGD	RGD:1565609

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