PAG1 - phosphoprotein membrane anchor with glycosphingolipid microdomains 1 Gene

Homo sapiens

Also known as CBP; PAG

Gene ID: 55824 | Gene type: protein coding

About PAG1

Cytogenetic location: 8q21.13 Genomic coordinates (GRCh38): 8:80,967,810-81,112,068 (from NCBI)

This gene has 4 transcripts (splice variants) and 193 orthologues. Broad expression in lymph node (RPKM 8.7), placenta (RPKM 8.2) and 25 other tissues.

Summary

The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation. [provided by RefSeq, Jul 2008]

PAG1 Products(1)

mRNA	Protein	Name
NM_018440.4	NP_060910.3	phosphoprotein associated with glycosphingolipid-enriched microdomains 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SH2 domain binding	IDA IDA: Inferred from direct assay	10790433	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10790433	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	10790433	GOA
involved in regulation of T cell activation	IDA IDA: Inferred from direct assay	10790433	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane raft	IDA IDA: Inferred from direct assay	10790433	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	10790433	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PAG1 Protein Structure

PAG

0
100
200
300
400
432 a.a.

Protein Preferred Names

Protein Names

phosphoprotein associated with glycosphingolipid-enriched microdomains 1

Csk-binding protein

PAG1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PAG1	Q9NWQ8	CSK	Homo sapiens	P41240	Anti Bait CoIP	18070987
Intra	PAG1	Q9NWQ8	RACK1	Homo sapiens	P63244	Anti Bait CoIP	23866081
Intra	PAG1	Q9NWQ8	FYN	Homo sapiens	P06241	Peptide Array	18056706
Intra	PAG1	Q9NWQ8	FYN	Homo sapiens	P06241	CoIP	18056706
Intra	PAG1	Q9NWQ8	LYN	Homo sapiens	P07948	Anti Bait CoIP	18070987
Intra	PAG1	Q9NWQ8	LYN	Homo sapiens	P07948	Anti Bait CoIP	23866081

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Chromosome 8q21.11 Deletion Syndrome

8q21.11 Microdeletion Syndrome	Del(8)(Q21.11)
Deletion 8q21.11	Monosomy 8q21.11

B-Lymphoblastic Leukemia/Lymphoma With Hypodiploidy

B-All With Hypodiploidy

Hypodiploid All

Peters-Plus Syndrome

Krause-Kivlin Syndrome	Peters Plus Syndrome
Peters Anomaly	Irido-Corneo-Trabecular Dysgenesis
PTRPLS	Peters Anomaly With Short-Limb Dwarfism
Peters Anomaly-Short Limb Dwarfism Syndrome	Peters Anomaly With Short Limb Dwarfism
Peters Congenital Glaucoma	Krause-Van Schooneveld-Kivlin Syndrome
Peters' Plus Syndrome	Peters'-Plus Syndrome
Anomaly Peters

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09971	PAG1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PAG1	VGNC	VGNC:32553
Felis catus	PAG1	VGNC	VGNC:64025
Rattus norvegicus	PAG1	RGD	RGD:620394
Canis familiaris	PAG1	VGNC	VGNC:44242
Mus musculus	PAG1	MGD	MGI:2443160
Macaca mulatta	PAG1	VGNC	VGNC:75698
Others	PAG1	NCBI

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