ACOT13 - acyl-CoA thioesterase 13 Gene

Homo sapiens

Also known as HT012; THEM2; PNAS-27

Gene ID: 55856 | Gene type: protein coding

About ACOT13

Cytogenetic location: 6p22.3 Genomic coordinates (GRCh38): 6:24,667,077-24,705,046 (from NCBI)

This gene has 3 transcripts (splice variants) and 200 orthologues. Ubiquitous expression in kidney (RPKM 18.3), liver (RPKM 16.3) and 25 other tissues.

Summary

This gene encodes a member of the thioesterase superfamily. In humans, the protein co-localizes with microtubules and is essential for sustained cell proliferation. The orthologous mouse protein forms a homotetramer and is associated with mitochondria. The mouse protein functions as a medium- and long-chain acyl-CoA thioesterase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2009]

ACOT13 Products(2)

mRNA	Protein	Name
NM_001160094.2	NP_001153566.1	acyl-coenzyme A thioesterase 13 isoform 2
NM_018473.4	NP_060943.1	acyl-coenzyme A thioesterase 13 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables fatty acyl-CoA hydrolase activity	IDA IDA: Inferred from direct assay	16934754	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein homotetramerization	IPI IPI: Inferred from physical interaction	16934754	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACOT13 Protein Structure

4HBT

0
100
140 a.a.

Protein Preferred Names

Protein Names

acyl-coenzyme A thioesterase 13

hotdog-fold thioesterase superfamily member 2

ACOT13 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ACOT13	Q9NPJ3	YWHAG	Homo sapiens	P61981	Y2H Array	32814053
Intra	ACOT13	Q9NPJ3	YWHAG	Homo sapiens	P61981	Y2H Pooling	32814053
Intra	ACOT13	Q9NPJ3	YWHAG	Homo sapiens	P61981	Validated Y2H	32814053
Intra	ACOT13	Q9NPJ3	KAT5	Homo sapiens	Q92993	Y2H Pooling	32814053
Intra	ACOT13	Q9NPJ3	KAT5	Homo sapiens	Q92993	Validated Y2H	32814053
Intra	ACOT13	Q9NPJ3	KAT5	Homo sapiens	Q92993	Y2H Array	32814053
Intra	ACOT13	Q9NPJ3	SPG21	Homo sapiens	Q9NZD8	Validated Y2H	32296183
Intra	ACOT13	Q9NPJ3	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053
Intra	ACOT13	Q9NPJ3	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
Intra	ACOT13	Q9NPJ3	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ACOT13 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7452	ACOT13 Protein, Human (HEK293, His)	Q9NPJ3-1 (T2-N140)	≥95%

Related Diseases

Diseases

Alias

Dyslexia

Reading Disorder

Specific Reading Disorder	Reading
Dyslexia	Developmental Reading Disorder

Learning Disability

Learning Disabilities	Learning Disorders
Academic Skill Disorder	Learning Disorder

Leukoencephalopathy With Vanishing White Matter

Cree Leukoencephalopathy	Vanishing White Matter Disease
Ovarioleukodystrophy	Vanishing White Matter Leukodystrophy
Childhood Ataxia With Central Nervous System Hypomyelinization	Cach
Cach Syndrome	Myelinosis Centralis Diffusa
VWM	Cle
Childhood Ataxia With Central Nervous System Hypomyelination	Childhood Ataxia With Diffuse Central Nervous System Hypomyelination
Cach/Vwm	Cach/Vwm Syndrome
Childhood Ataxia With Central Nervous System Hypomyelination/Vanishing White Matter	Cree Leukoencehalopathy
Late Infantile Cach Syndrome	Juvenile Or Adult Cach Syndrome
Congenital Or Early Infantile Cach Syndrome	Leukodystrophy With Vanishing White Matter

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00176	ACOT13 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ACOT13	VGNC	VGNC:37518
Macaca mulatta	ACOT13	VGNC	VGNC:69487
Mus musculus	ACOT13	MGD	MGI:1914084
Bos taurus	ACOT13	VGNC	VGNC:25549
Felis catus	ACOT13	VGNC	VGNC:102373
Rattus norvegicus	ACOT13	RGD	RGD:1306513
Others	ACOT13	NCBI

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