GSDMB - gasdermin B Gene

Homo sapiens

Also known as GSDML; PP4052; GSDMB-1; PRO2521

Gene ID: 55876 | Gene type: protein coding

About GSDMB

Cytogenetic location: 17q21.1 Genomic coordinates (GRCh38): 17:39,904,595-39,918,635 (from NCBI)

This gene has 15 transcripts (splice variants), 150 orthologues and 4 paralogues. Broad expression in small intestine (RPKM 18.8), duodenum (RPKM 16.9) and 17 other tissues.

Summary

This gene encodes a member of the gasdermin-domain containing protein family. Other gasdermin-family genes are implicated in the regulation of Apoptosis in epithelial cells, and are linked to Cancer. Alternative splicing and the use of alternative promoters results in multiple transcript variants. Additional variants have been described, but they are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding. [provided by RefSeq, Nov 2016]

GSDMB Products(10)

mRNA	Protein	Name
NM_001042471.2	NP_001035936.1	gasdermin-B isoform 1
NM_001165958.2	NP_001159430.1	gasdermin-B isoform 3
NM_001165959.2	NP_001159431.1	gasdermin-B isoform 4
NM_001369402.2	NP_001356331.1	gasdermin-B isoform 1
NM_001388420.1	NP_001375349.1	gasdermin-B isoform 3
NM_001388421.1	NP_001375350.1	gasdermin-B isoform 4
NM_001388422.1	NP_001375351.1	gasdermin-B isoform 1
NM_001388423.1	NP_001375352.1	gasdermin-B isoform 2
NM_001388424.1	NP_001375353.1	gasdermin-B isoform 5
NM_018530.3	NP_061000.2	gasdermin-B isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cardiolipin binding	IDA IDA: Inferred from direct assay	34022140	GOA
enables phospholipid binding	IDA IDA: Inferred from direct assay	28154144	GOA
enables wide pore channel activity	IDA IDA: Inferred from direct assay	32299851	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cytotoxic T cell pyroptotic cell death	IDA IDA: Inferred from direct assay	28154144	GOA
involved in defense response to Gram-negative bacterium	IDA IDA: Inferred from direct assay	34022140	GOA
involved in granzyme-mediated programmed cell death signaling pathway	IDA IDA: Inferred from direct assay	32299851	GOA
involved in killing by host of symbiont cells	IDA IDA: Inferred from direct assay	34022140	GOA
NOT involved in pyroptotic inflammatory response	IDA IDA: Inferred from direct assay	36899106	GOA
involved in pyroptotic inflammatory response	IDA IDA: Inferred from direct assay	32299851	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in plasma membrane	IDA IDA: Inferred from direct assay	28154144	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GSDMB Protein Structure

Gasdermin

0
100
200
300
416 a.a.

Protein Preferred Names

Protein Names

gasdermin-B

gasdermin-like protein

Related Diseases

Diseases

Alias

Oral Squamous Cell Carcinoma

Mouth Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Mouth

Childhood-Onset Asthma

Childhood Asthma

Asthma Childhood

Chronic Asthma

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05855	GSDMB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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