PRKG2 - protein kinase cGMP-dependent 2 Gene

Homo sapiens

Also known as AMD4; PKG2; SMDP; cGK2; cGKII; PRKGR2

Gene ID: 5593 | Gene type: protein coding

About PRKG2

Cytogenetic location: 4q21.21 Genomic coordinates (GRCh38): 4:81,087,370-81,217,836 (from NCBI)

This gene has 7 transcripts (splice variants), 185 orthologues, 5 paralogues and is associated with 3 phenotypes. Biased expression in prostate (RPKM 4.2), small intestine (RPKM 4.1) and 11 other tissues.

Summary

This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein binds to and inhibits the activation of several Receptor Tyrosine Kinases. The membrane-bound protein is a regulator of intestinal secretion, bone growth and Renin secretion. Alternate splicing results in multiple transcript variants encoding distinct isoforms whose regulatory N-termini differ in length but whose C-terminal catalytic domains are identical. [provided by RefSeq, May 2018]

PRKG2 Products(7)

mRNA	Protein	Name
NM_001282480.1	NP_001269409.1	cGMP-dependent protein kinase 2 isoform b
NM_001282481.1	NP_001269410.1	cGMP-dependent protein kinase 2 isoform b
NM_001282482.1	NP_001269411.1	cGMP-dependent protein kinase 2 isoform c
NM_001282483.1	NP_001269412.1	cGMP-dependent protein kinase 2 isoform d
NM_001282485.2	NP_001269414.1	cGMP-dependent protein kinase 2 isoform e
NM_001363401.2	NP_001350330.1	cGMP-dependent protein kinase 2 isoform a
NM_006259.3	NP_006250.1	cGMP-dependent protein kinase 2 isoform a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables cGMP-dependent protein kinase activity	IMP IMP: Inferred from mutant phenotype	33106379	GOA
enables mitogen-activated protein kinase binding	IMP IMP: Inferred from mutant phenotype	33106379	GOA
enables protein serine kinase activity	IMP IMP: Inferred from mutant phenotype	33106379	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	15905169	GOA
involved in signal transduction	IMP IMP: Inferred from mutant phenotype	33106379	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRKG2 Protein Structure

cNMP_binding

Pkinase

0
200
400
600
762 a.a.

Protein Preferred Names

Protein Names

cGMP-dependent protein kinase 2

cGMP-dependent protein kinase II

Related Diseases

Diseases

Alias

Spondylometaphyseal Dysplasia, Pagnamenta Type

SMDP	Dysplasia, Spondylometaphyseal, Pagnamenta Type

Acromesomelic Dysplasia 4

AMD4	Acromesomelic Dysplasia-4
Dysplasia, Acromesomelic, Type 4

Acromesomelic Dysplasia

Acromesomelic Dwarfism	Dysplasia, Acromesomelic
Acromesomelic Dysplasia Hunter-Thompson Type

Chromosome 4q21 Deletion Syndrome

4q21 Microdeletion Syndrome	Monosomy 4q21
Del(4)(Q21)	Chromosome Deletion Syndrome 4q21

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Hyperphenylalaninemia

Hyperphenylalaninaemia

Brachydactyly

Malignant Hemangioma

Secretory Diarrhea

Alcohol Dependence

Alcoholism	Alcohol Dependence, Susceptibility To
Alcohol Dependence, Protection Against	Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against
Alcoholism, Susceptibility To	Alcoholic Intoxication, Chronic
Pharyngeal Neoplasms	Chronic Alcoholism
Dipsomania	Alcohol Addiction
Ethanol Dependence	Chronic Ethanolism
Chronic Alcoholic Disease Nos	Alcoholic Disease Nos
Alcoholic

Osteochondrodysplasia

Skeletal Dysplasia	Chondrodystrophy
Congenital Anomaly Of Cartilage	Osteochondrodysplasias
Cartilage Development Disorder	Osteochondrodysplasia Syndrome
Dysplasia, Skeletal	Mucopolysaccharidosis Iv

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11155	PRKG2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PRKG2	VGNC	VGNC:44990
Mus musculus	PRKG2	MGD	MGI:108173
Macaca mulatta	PRKG2	VGNC	VGNC:76420
Bos taurus	PRKG2	VGNC	VGNC:33341
Rattus norvegicus	PRKG2	RGD	RGD:3401
Felis catus	PRKG2	VGNC	VGNC:69070
Others	PRKG2	NCBI

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