Sfn - stratifin Gene

Mus musculus

Also known as Er; Mme1; Ywhas; 14-3-3

Gene ID: 55948 | Gene type: protein coding

About Sfn

Summary

Enables phosphoprotein binding activity and protein kinase binding activity. Involved in several processes, including establishment of skin barrier; positive regulation of protein export from nucleus; and regulation of epidermal cell division. Acts upstream of or within keratinocyte differentiation; negative regulation of keratinocyte proliferation; and regulation of cyclin-dependent protein serine/threonine kinase activity. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in transitional cell carcinoma and vulva squamous cell carcinoma. Orthologous to human SFN (stratifin). [provided by Alliance of Genome Resources, Apr 2022]

Sfn Products(1)

mRNA	Protein	Name
NM_018754.2	NP_061224.2	14-3-3 protein sigma

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphoprotein binding	IPI IPI: Inferred from physical interaction	17938205	MGI
enables protein binding	IDA IDA: Inferred from direct assay	18606808	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16710422	MGI
enables protein kinase binding	IDA IDA: Inferred from direct assay	10767298	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cAMP/PKA signal transduction	IDA IDA: Inferred from direct assay	18606808	MGI
involved in establishment of skin barrier	IMP IMP: Inferred from mutant phenotype	24075906	MGI
acts upstream of or within keratinization	IMP IMP: Inferred from mutant phenotype	6174530	MGI
acts upstream of or within keratinocyte development	IGI IGI: Inferred from genetic interaction	24075906	MGI
acts upstream of or within keratinocyte differentiation	IMP IMP: Inferred from mutant phenotype	16239341	MGI
acts upstream of keratinocyte proliferation	IGI IGI: Inferred from genetic interaction	17041603	MGI
acts upstream of or within negative regulation of keratinocyte proliferation	IGI IGI: Inferred from genetic interaction	17041603	MGI
acts upstream of or within negative regulation of stem cell proliferation	IGI IGI: Inferred from genetic interaction	17041603	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18606808	MGI
involved in positive regulation of cell growth	IDA IDA: Inferred from direct assay	16710422	MGI
involved in positive regulation of epidermal cell differentiation	IMP IMP: Inferred from mutant phenotype	24075906	MGI
involved in positive regulation of protein export from nucleus	IDA IDA: Inferred from direct assay	17938205	MGI
involved in protein export from nucleus	IDA IDA: Inferred from direct assay	18606808	MGI
acts upstream of or within regulation of cell cycle	IDA IDA: Inferred from direct assay	10767298	MGI
acts upstream of or within regulation of cyclin-dependent protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	10767298	MGI
involved in regulation of epidermal cell division	IMP IMP: Inferred from mutant phenotype	24075906	MGI
acts upstream of or within skin development	IGI IGI: Inferred from genetic interaction	17041603	MGI
acts upstream of or within skin development	IMP IMP: Inferred from mutant phenotype	16239341	MGI
acts upstream of stem cell proliferation	IGI IGI: Inferred from genetic interaction	17041603	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16710422	MGI
located in nucleus	IDA IDA: Inferred from direct assay	16710422	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

14-3-3 protein sigma

14-3-3 sigma protein

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, sigma polypeptide

Recombinant Sfn Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74438	14-3-3 sigma Protein, Mouse	O70456 (M1-S248)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-132242	DL-Sulforaphane N-acetyl-L-cysteine		99.90%	Unkown
HY-RS12769	SFN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W588248	DL-Sulforaphane glutathione		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sfn	NCBI	NCBI:2810

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