2. Gene
  3. GNG12 - G protein subunit gamma 12 Gene

GNG12 - G protein subunit gamma 12 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as HG3A

Gene ID: 55970 | Gene type: protein coding

About GNG12

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:67,701,475-67,833,467 (from NCBI)

This gene has 2 transcripts (splice variants), 248 orthologues and 11 paralogues. Ubiquitous expression in duodenum (RPKM 59.3), small intestine (RPKM 55.3) and 24 other tissues.

Summary

Enables PDZ domain binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

GNG12 Products(1)

mRNA Protein Name
NM_018841.6 NP_061329.3 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables PDZ domain binding IDA
IDA: Inferred from direct assay
23209302 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21988832 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GNG12 Protein Structure

G-gamma

G-gamma: GGL domain (12 - 72)

  • 0
  • 72 a.a.
Protein Preferred Names Protein Names

guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

G-protein gamma-12 subunit

GNG12 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
GNG12 Q9UBI6 FHL2 Homo sapiens Q14192
Y2H Array
31515488
Intra
GNG12 Q9UBI6 FHL2 Homo sapiens Q14192
Y2H Prey Pooling
32296183
Intra
GNG12 Q9UBI6 FHL2 Homo sapiens Q14192
Y2H Array
32296183
Intra
GNG12 Q9UBI6 FHL2 Homo sapiens Q14192
Validated Y2H
25416956
Intra
GNG12 Q9UBI6 FHL2 Homo sapiens Q14192
Y2H
21988832
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05554 GNG12 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris GNG12 VGNC VGNC:41318
Macaca mulatta GNG12 VGNC VGNC:106371
Rattus norvegicus GNG12 RGD RGD:621516
Mus musculus GNG12 MGD MGI:1336171
Bos taurus GNG12 VGNC VGNC:29463