MEPCE - methylphosphate capping enzyme Gene

Homo sapiens

Also known as BCDIN3

Gene ID: 56257 | Gene type: protein coding

About MEPCE

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,428,790-100,434,118 (from NCBI)

This gene has 7 transcripts (splice variants), 196 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 29.4), spleen (RPKM 17.1) and 25 other tissues.

Summary

Enables 7SK snRNA binding activity and RNA 5'-methyltransferase activity. Involved in RNA modification; positive regulation of protein localization to Cajal body; and positive regulation of snRNA transcription by RNA polymerase II. Located in nucleus. Part of 7SK snRNP. [provided by Alliance of Genome Resources, Apr 2022]

MEPCE Products(5)

mRNA	Protein	Name
NM_001194990.2	NP_001181919.1	7SK snRNA methylphosphate capping enzyme isoform B
NM_001194991.2	NP_001181920.1	7SK snRNA methylphosphate capping enzyme isoform B
NM_001194992.2	NP_001181921.1	7SK snRNA methylphosphate capping enzyme isoform B
NM_001363486.2	NP_001350415.1	7SK snRNA methylphosphate capping enzyme isoform B
NM_019606.6	NP_062552.2	7SK snRNA methylphosphate capping enzyme isoform A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 7SK snRNA binding	IDA IDA: Inferred from direct assay	28431135	GOA
enables RNA 5'-gamma-phosphate methyltransferase activity	IDA IDA: Inferred from direct assay	19906723	GOA
enables RNA binding	IPI IPI: Inferred from physical interaction	30559425	GOA
enables RNA methyltransferase activity	IDA IDA: Inferred from direct assay	17643375	GOA
enables RNA methyltransferase activity	IMP IMP: Inferred from mutant phenotype	24360279	GOA
enables S-adenosylmethionine-dependent methyltransferase activity	IDA IDA: Inferred from direct assay	17643375	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	30824372	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in RNA methylation	IDA IDA: Inferred from direct assay	17643375	GOA
involved in positive regulation of protein localization to Cajal body	IDA IDA: Inferred from direct assay	28254838	GOA
involved in positive regulation of snRNA transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	28254838	GOA
involved in snRNA metabolic process	IDA IDA: Inferred from direct assay	17643375	GOA
involved in snRNA modification	IDA IDA: Inferred from direct assay	17643375	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of 7SK snRNP	IDA IDA: Inferred from direct assay	17643375	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19906723	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	19906723	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MEPCE Protein Structure

Bin3

0
200
400
600
689 a.a.

Protein Preferred Names

Protein Names

7SK snRNA methylphosphate capping enzyme

bicoid-interacting protein 3 homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08338	MEPCE Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MEPCE	MGD	MGI:106477
Bos taurus	MEPCE	VGNC	VGNC:106819
Canis familiaris	MEPCE	VGNC	VGNC:43161
Rattus norvegicus	MEPCE	RGD	RGD:1560550
Macaca mulatta	MEPCE	VGNC	VGNC:74541
Felis catus	MEPCE	VGNC	VGNC:63450

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