LGMN - legumain Gene

Homo sapiens

Also known as AEP; LGMN1; PRSC1

Gene ID: 5641 | Gene type: protein coding

About LGMN

Cytogenetic location: 14q32.12 Genomic coordinates (GRCh38): 14:92,703,809-92,748,627 (from NCBI)

This gene has 19 transcripts (splice variants), 210 orthologues and 1 paralogue. Ubiquitous expression in placenta (RPKM 135.7), spleen (RPKM 98.7) and 23 other tissues.

Summary

This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This Enzyme may be involved in the processing of Bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active Enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008]

LGMN Products(4)

mRNA	Protein	Name
NM_001008530.3	NP_001008530.1	legumain isoform 1 preproprotein
NM_001363696.2	NP_001350625.1	legumain isoform 2 precursor
NM_001363699.2	NP_001350628.1	legumain isoform 3 precursor
NM_005606.7	NP_005597.3	legumain isoform 1 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	9821970	GOA
enables cysteine-type endopeptidase activity	IMP IMP: Inferred from mutant phenotype	9065484	GOA
enables endopeptidase activator activity	IDA IDA: Inferred from direct assay	18374643	GOA
enables peptidase activity	IDA IDA: Inferred from direct assay	136644	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25630877	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	9821970	GOA
involved in antigen processing and presentation of exogenous peptide antigen via MHC class II	IDA IDA: Inferred from direct assay	9872320	GOA
involved in cellular response to amyloid-beta	IDA IDA: Inferred from direct assay	25326800	GOA
involved in cellular response to calcium ion	IDA IDA: Inferred from direct assay	21237226	GOA
involved in cellular response to hepatocyte growth factor stimulus	IDA IDA: Inferred from direct assay	21237226	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	21237226	GOA
acts upstream of or within negative regulation of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	18374643	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	21237226	GOA
involved in positive regulation of endothelial cell chemotaxis	IDA IDA: Inferred from direct assay	18377911	GOA
involved in positive regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	21237226	GOA
involved in positive regulation of monocyte chemotaxis	IDA IDA: Inferred from direct assay	18377911	GOA
involved in response to acidic pH	IDA IDA: Inferred from direct assay	18374643	GOA
involved in self proteolysis	IDA IDA: Inferred from direct assay	9821970	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	18377911	GOA
located in extracellular region	IDA IDA: Inferred from direct assay	18377911	GOA
is active in lysosomal lumen	IDA IDA: Inferred from direct assay	9872320	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	21237226	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LGMN Protein Structure

Peptidase_C13

0
100
200
300
400
433 a.a.

Protein Preferred Names

Protein Names

legumain

asparaginyl endopeptidase

Related Diseases

Diseases

Alias

Schistosomiasis

Katayama Fever	Bilharzia
Bilharziasis	Schistosomiasis Mansoni
Blood Fluke	Schistosoma Mansoni Infection
Snail Fever	Acute Schistosomiasis
Schistosomiasis Manson	Schistosomiasis Due To Schistosoma Mansoni [Intestinal Schistosomiasis]
Intestinal Schistosomiasis Nos	Intestinal Schistosomiasis
Egyptian Splenomegaly	Bilharziasis Of Intestine
Schistosomal Dysentery	Schistosomiasis Of Colon
Asiatic Schistosomiasis	Eastern Schistosomiasis
Schistosoma Japonicum Infection	Schistosomiasis Japonicum
Katayama Disease	Katayama Syndrome
Oriental Schistosomiasis

Aneruptive Fever

Rickettsia Helvetica Spotted Fever

Cerebral Amyloid Angiopathy, Cst3-Related

Cerebral Amyloid Angiopathy	Hereditary Cerebral Hemorrhage With Amyloidosis
Hchwa	Hereditary Cystatin C Amyloid Angiopathy
Cerebral Amyloid Angiopathy, Familial	Amyloidosis, Cerebroarterial, Icelandic Type
Amyloidosis Vi	Cerebral Hemorrhage, Hereditary, With Amyloidosis
Cst3-Related Cerebral Amyloid Angiopathy	Cerebral Hemorrhage, Hereditary, With Amyloidosis, Icelandic Variant
Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Variant	Caa, Familial
Cerebral Amyloid Angiopathy, Genetic	Acys Amyloidosis
Cst3-Related Amyloidosis	Cystatin Amyloidosis
Hchwa, Icelandic Type	Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Type
Amyloidosis 6	AMYL6
Acys	Caa
Cerebral Amyloid Angiopathy Cst3-Related	Cerebroarterial Amyloidosis Icelandic Type
Cystatin C Amyloidosis	Hccaa
Hchwai	Hchwa-I
Hereditary Cerebral Hemorrhage With Amyloidosis Icelandic Type	Cerebral Amyloid Angiopathy Familial
Angiopathy, Amyloid, Cerebral, Cst3-Related	Hereditary Cerebral Amyloid Angiopathy, Icelandic Type
Familial Cerebral Amyloid Angiopathy	Cerebral Amyloid Angiopathy, Hereditary

Keratosis Follicularis Spinulosa Decalvans, Autosomal Dominant

Autosomal Dominant Keratosis Follicularis Spinulosa Decalvans

KFSD

Trichomoniasis

Trichomonas Infection	Trichomonas Infections
Disease Due To Trichomonadidae	Infection By Trichomonas
Trichomonadosis	Trichomonas Pruritus
Trichomonosis	Tricomoniasis

Tick Infestation

Tick Infestations

Robinow Syndrome, Autosomal Recessive 1

Robinow Syndrome, Autosomal Recessive	Autosomal Recessive Robinow Syndrome
Covesdem Syndrome	RRS1
Costovertebral Segmentation Defect-Mesomelia Syndrome	Rrs
Costovertebral Segmentation Defect With Mesomelia, Formerly	Covesdem Syndrome, Formerly
Costovertebral Segmentation Defect With Mesomelia	Robinow Syndrome Autosomal Recessive With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals
Robinow Syndrome Autosomal Recessive With Brachy-Syn-Polydactyly	Robinow Syndrome, Autosomal Recessive, With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals
Robinow Syndrome, Autosomal Recessive, With Brachy-Syn-Polydactyly	Robinow, Autosomal Recessive Syndrome, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07617	LGMN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	LGMN	VGNC	VGNC:30860
Macaca mulatta	LGMN	VGNC	VGNC:74274
Canis familiaris	LGMN	VGNC	VGNC:42654
Felis catus	LGMN	VGNC	VGNC:69086
Rattus norvegicus	LGMN	RGD	RGD:619832
Mus musculus	LGMN	MGD	MGI:1330838
Susscrofa domestica	LGMN	NCBI
Others	LGMN	NCBI

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