PRSS3 - serine protease 3 Gene

Homo sapiens

Also known as T9; MTG; TRY3; TRY4; PRSS4

Gene ID: 5646 | Gene type: protein coding

About PRSS3

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:33,750,679-33,799,231 (from NCBI)

This gene has 7 transcripts (splice variants), 474 orthologues and 3 paralogues. Restricted expression toward pancreas (RPKM 3091.3).

Summary

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This Enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2010]

PRSS3 Products(4)

mRNA	Protein	Name
NM_001197097.3	NP_001184026.3	trypsin-3 isoform 3 preproprotein
NM_001197098.1	NP_001184027.1	trypsin-3 isoform 4 preproprotein
NM_002771.4	NP_002762.3	trypsin-3 isoform 2 preproprotein
NM_007343.4	NP_031369.3	trypsin-3 isoform 1 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	6698368	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	6698368	GOA
enables serine-type endopeptidase activity	IDA IDA: Inferred from direct assay	6698368	GOA
enables serine-type peptidase activity	IDA IDA: Inferred from direct assay	9099703	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in endothelial cell migration	IMP IMP: Inferred from mutant phenotype	15313892	GOA
involved in proteolysis	IDA IDA: Inferred from direct assay	6698368	GOA
involved in zymogen activation	IDA IDA: Inferred from direct assay	6698368	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	6698368	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRSS3 Protein Structure

Trypsin

0
100
200
304 a.a.

Protein Preferred Names

Protein Names

trypsin-3

brain trypsinogen

Recombinant PRSS3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71456	PRSS3/Trypsin-3 Protein, Human (His)	P35030 (I81-N303)	≥95%
HY-P75985	PRSS3/Trypsin-3 Protein, Human (HEK293, His)	P35030-3 (V16-S247)	≥95%

Related Diseases

Diseases

Alias

Thyroiditis

Inflammation Of Thyroid

Thyroiditis Nos

Hashimoto Thyroiditis

Autoimmune Thyroiditis	Hashimoto Struma
Hashimoto'S Thyroiditis	Chronic Lymphocytic Thyroiditis
Lymphocytic Thyroiditis	Hashimoto Disease
Ht	Hashimoto'S Disease
Hashimoto'S Syndrome	Hypothyroidism, Autoimmune
Autoimmune Chronic Lymphocytic Thyroiditis	Chronic Lymphocytic Thyroiditides
Hashimoto Syndrome	Hashimotos Thyroiditis
Hashimoto Thyroiditis, Susceptibility To	Thyroiditis, Autoimmune
Lymphomatous Thyroiditis	Lymphoid Thyroiditis
Chronic Lymphadenoid Thyroiditis	Autoimmune Lymphocytic Chronic Thyroiditis
Goitre Lymphomatosa	Hashitoxicosis
Hashimoto Hypothyroidism	Lymphadenoid Goitre
Struma Lymphomatosa	Hyperthyroidism With Hashimoto Disease
Hashimoto Thyrotoxicosis	Thyrotoxicosis Due To Hashimoto Thyroiditis
Struma Lymphomatosis	Lymphadenoid Struma

Pancreatitis

Mumps Pancreatitis

Pancreatitis, Hereditary

Hereditary Pancreatitis	Chronic Pancreatitis
Hereditary Chronic Pancreatitis	Hp
Pancreatitis, Chronic, Susceptibility To	PCTT
Hpc	Pancreatitis, Chronic
Pancreatitis, Chronic, Protection Against	Autosomal Dominant Hereditary Pancreatitis
Familial Pancreatitis	Cp
Pancreatitis Hereditary

Autoimmune Disease Of Endocrine System

Celiac Disease 1

Celiac Disease	Coeliac Disease
Celiac Sprue	Celiac Disease, Susceptibility To
Gluten-Sensitive Enteropathy	Nontropical Sprue
Sprue	CELIAC1
Celiac Disease, Susceptibility To, 1	Celiac Sprue 1
Celiac Sprue, Susceptibility To, 1	Gluten-Sensitive Enteropathy 1
Gluten-Sensitive Enteropathy, Susceptibility To, 1	Idiopathic Steatorrhea
Cœliac Disease	Gluten Intolerance
Gluten-Induced Enteropathy	Gluten Enteropathy
Celiac Disease, Susceptibility To, Type 1	Childhood Celiac Disease
Coeliac Rickets	Gee Disease
Gee-Herter Disease	Heubner-Herter Disease
Idiopathic Steatorrhoea	Thaysen'S Disease
Herter Gee Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11253	PRSS3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PRSS3	RGD	RGD:1311446
Others	PRSS3	NCBI

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