2. Gene
  3. Cldn18 - claudin 18 Gene

Cldn18 - claudin 18 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 56492 | Gene type: protein coding

About Cldn18

Summary

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is a downstream target gene regulated by the T/EBP/NKX2.1 homeodomain transcription factor. Four alternatively spliced transcript variants resulted from alternative promoters and alternative splicing have been identified, which encode two lung-specific isoforms and two stomach-specific isoforms respectively. This gene is also expressed in colons, inner ear and skin, and its expression is increased in both experimental colitis and ulcerative colitis. [provided by RefSeq, Aug 2010]

Cldn18 Products(4)

mRNA Protein Name
NM_001194921.1 NP_001181850.1 claudin-18 isoform A2.1
NM_001194922.1 NP_001181851.1 claudin-18 isoform A1.2 precursor
NM_001194923.1 NP_001181852.1 claudin-18 isoform A2.2
NM_019815.3 NP_062789.1 claudin-18 isoform A1.1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
19706394 MGI
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to estrogen stimulus IMP
IMP: Inferred from mutant phenotype
23299504 MGI
acts upstream of or within digestive tract development IMP
IMP: Inferred from mutant phenotype
22437732 MGI
involved in epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
29400695 MGI
involved in epithelial fluid transport IMP
IMP: Inferred from mutant phenotype
24588076 MGI
involved in lung alveolus development IMP
IMP: Inferred from mutant phenotype
24787463 MGI
acts upstream of or within negative regulation of bone resorption IMP
IMP: Inferred from mutant phenotype
22437732 MGI
acts upstream of or within negative regulation of osteoclast development IMP
IMP: Inferred from mutant phenotype
22437732 MGI
acts upstream of or within negative regulation of protein localization to nucleus IDA
IDA: Inferred from direct assay
22437732 MGI
involved in negative regulation of protein localization to nucleus IMP
IMP: Inferred from mutant phenotype
29400695 MGI
acts upstream of or within negative regulation of tumor necrosis factor-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
22437732 MGI
involved in organ growth IMP
IMP: Inferred from mutant phenotype
29400695 MGI
acts upstream of protein localization to nucleus IDA
IDA: Inferred from direct assay
22437732 MGI
involved in tight junction assembly IMP
IMP: Inferred from mutant phenotype
22079592 MGI
involved in tight junction organization IMP
IMP: Inferred from mutant phenotype
24588076 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cell-cell junction IDA
IDA: Inferred from direct assay
29400695 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
29400695 MGI
located in tight junction IDA
IDA: Inferred from direct assay
22079592 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

claudin-18

Recombinant Cldn18 Proteins

Cat. No. Product Name Accession Purity
HY-P700404 Claudin-18/CLDN18.2 Protein-VLP, Mouse (HEK293, His) P56857-3 (M1-V264) ≥95%

Related Agents

Clinical Phase
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99350 Gresonitamab 99.12% Phase 1
Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02768 CLDN18 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990742 Givastomig / Unkown
HY-P991027 Spevatamig / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cldn18 NCBI NCBI:51208
Macaca fascicularis Cldn18 NCBI NCBI:102126717