CLDN18 - claudin 18 Gene

Homo sapiens

Also known as SFTA5; SFTPJ

Gene ID: 51208 | Gene type: protein coding

About CLDN18

Cytogenetic location: 3q22.3 Genomic coordinates (GRCh38): 3:137,998,816-138,033,649 (from NCBI)

This gene has 3 transcripts (splice variants), 234 orthologues and 22 paralogues. Biased expression in stomach (RPKM 335.4) and lung (RPKM 153.8).

Summary

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010]

CLDN18 Products(2)

mRNA	Protein	Name
NM_001002026.3	NP_001002026.1	claudin-18 isoform 2
NM_016369.4	NP_057453.1	claudin-18 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19706394	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLDN18 Protein Structure

PMP22_Claudin

0
100
200
261 a.a.

Protein Preferred Names

Protein Names

claudin-18

surfactant associated 5

CLDN18 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CLDN18	P56856	EHHADH	Homo sapiens	Q08426	Validated Y2H	32296183
Intra	CLDN18	P56856	PMP22	Homo sapiens	Q01453	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CLDN18 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70045	Claudin-18/CLDN18.1 Protein, Human (His)	P56856-1 (D28-L76)	≥95%
HY-P70701	Claudin-18/CLDN18.2 Protein, Human (His)	P56856-2 (D28-L76)	≥95%
HY-P78105	Claudin-18/CLDN18.2 Protein-VLP, Human (Biotinylated, HEK293)	P56856-2 (M1-V261)	≥95%
HY-P78368	Claudin-18/CLDN18.2 Protein-VLP, Human (HEK293)	P56856-2 (M1-V261)	≥95%
HY-P700403	Claudin-18/CLDN18.2 Protein-VLP, Human (HEK293, His)	P56856-2 (M1-V261)	≥95%

Related Diseases

Diseases

Alias

Gastroesophageal Adenocarcinoma

Gastric And Esophageal Adenocarcinoma

Gastro-Esophageal Adenocarcinoma

Gastroesophageal Junction Adenocarcinoma

Adenocarcinoma Of Cardioesophageal Junction	Adenocarcinoma Of Gastroesophageal Junction
Adenocarcinoma Of The Gastroesophageal Junction

Colitis

Ulcerative Colitis

Colitis Gravis	Left Sided Ulcerative Colitis
Left-Sided Ulcerative Colitis	Idiopathic Proctocolitis
Inflammatory Bowel Disease, Ulcerative Colitis Type	Uc
Colitis Ulcerative	Colitis, Ulcerative
Chronic Left-Sided Ulcerative Colitis	Uc - [Ulcerative Colitis]
Chronic Ulcerative Enteritis	Mucosal Proctocolitis
Ulcerative Mucosal Proctocolitis	Left Hemicolitis

Bladder Urachal Carcinoma

Urachal Cancer

Urachal Carcinoma

Urachus Cancer

Malignant Tumor Of Urachus

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Diffuse Gastric Cancer

Hereditary Diffuse Gastric Adenocarcinoma	Hereditary Diffuse Gastric Cancer
Signet Cell Adenocarcinoma	Signet Ring Cell Carcinoma
Signet Ring Cell Gastric Carcinoma	Signet Ring Gastric Carcinoma
Fdgc	Familial Diffuse Cancer Of Stomach
Familial Diffuse Gastric Cancer	Gastric Cancer, Familial Diffuse
Gastric Cancer, Hereditary Diffuse	Hdgc
Hereditary Diffuse Cancer Of Stomach	Diffuse Gastric Cancer Syndrome
Cancer, Gastric, Diffuse	Carcinoma, Signet Ring Cell
Gastric Signet Ring Carcinoma

Signet Ring Cell Adenocarcinoma

Signet Ring Cell Carcinoma	Carcinoma, Signet Ring Cell
Signet Ring Carcinoma	Carcinoma Signet Ring Cell

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Diffuse Gastric And Lobular Breast Cancer Syndrome

Hereditary Diffuse Gastric Cancer	HDGC
LBC	Familial Diffuse Gastric Cancer
Fdgc	Hereditary Diffuse Gastric Adenocarcinoma
Breast Cancer, Lobular	Gastric Cancer, Familial Diffuse, And Cleft Lip With Or Without Cleft Palate
DGLBC	Gastric Cancer, Hereditary Diffuse
Gastric Cancer, Familial Diffuse Breast Cancer, Lobular	Diffuse Gastric And Lobular Breast Cancer Syndrome With Or Without Cleft Lip And/Or Palate
E-Cadherin-Associated Hereditary Gastric Cancer	Familial Diffuse Cancer Of Stomach
Hereditary Diffuse Cancer Of Stomach	Gastric Cancer Familial Diffuse
Gastric Cancer Familial Diffuse And Cleft Lip With Or Without Cleft Palate	Cancer, Gastric, Hereditary Diffuse

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99350	Gresonitamab		99.12%	Phase 1

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02768	CLDN18 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990742	Givastomig		/	Unkown
HY-P991027	Spevatamig		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CLDN18	VGNC	VGNC:27408
Canis familiaris	CLDN18	VGNC	VGNC:39314
Rattus norvegicus	CLDN18	RGD	RGD:1359696
Mus musculus	CLDN18	MGD	MGI:1929209
Macaca mulatta	CLDN18	VGNC	VGNC:71248
Felis catus	CLDN18	VGNC	VGNC:60933
Macaca fascicularis	CLDN18	NCBI	NCBI:102126717
Others	CLDN18	NCBI

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