Mast1 - microtubule associated serine/threonine kinase 1 Gene

Mus musculus

Also known as SAST; SAST170; 9430008B02Rik

Gene ID: 56527 | Gene type: protein coding

About Mast1

Summary

Enables microtubule binding activity. Involved in brain development and Cytoskeleton organization. Located in membrane; neuron projection; and neuronal cell body. Is expressed in nervous system; neural retina; and skeletal muscle. Used to study mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations. Human ortholog(s) of this gene implicated in mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations. Orthologous to human MAST1 (microtubule associated serine/threonine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Mast1 Products(1)

mRNA	Protein	Name
NM_019945.2	NP_064329.2	microtubule-associated serine/threonine-protein kinase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables microtubule binding	IDA IDA: Inferred from direct assay	30449657	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10404183	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in brain development	IMP IMP: Inferred from mutant phenotype	30449657	MGI
involved in cytoskeleton organization	IDA IDA: Inferred from direct assay	12477932	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	10404183	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	30449657	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	30449657	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

microtubule-associated serine/threonine-protein kinase 1

syntrophin associated serine/threonine kinase

syntrophin-associated serine-threonine protein kinase

Mast1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Mast1	Q9R1L5	PTEN	Homo sapiens	P60484	Beta Galactosidase	15951562

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08161	MAST1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mast1	NCBI	NCBI:22983

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