Clec7a - C-type lectin domain family 7, member a Gene

Mus musculus

Also known as BGR; beta-GR; Clecsf12

Gene ID: 56644 | Gene type: protein coding

About Clec7a

Summary

Predicted to enable (1->3)-beta-D-glucan binding activity and pattern recognition receptor activity. Predicted to be involved in several processes, including phagocytosis, recognition; positive regulation of cytokine production involved in inflammatory response; and response to fungus. Predicted to be active in cell surface. Is expressed in brain; gut; limb; musculature; and ventral grey horn. Human ortholog(s) of this gene implicated in aspergillosis and chronic mucocutaneous candidiasis. Orthologous to human CLEC7A (C-type lectin domain containing 7A). [provided by Alliance of Genome Resources, Apr 2022]

Clec7a Products(2)

mRNA	Protein	Name
NM_001309637.2	NP_001296566.1	C-type lectin domain family 7 member A isoform 2
NM_020008.4	NP_064392.2	C-type lectin domain family 7 member A isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables (1->3)-beta-D-glucan binding	IDA IDA: Inferred from direct assay	12163569	MGI
enables (1->3)-beta-D-glucan immune receptor activity	IDA IDA: Inferred from direct assay	12719478	MGI
enables opsonin binding	IDA IDA: Inferred from direct assay	12163569	MGI
enables pattern recognition receptor activity	IDA IDA: Inferred from direct assay	19136564	MGI
enables pattern recognition receptor activity	IMP IMP: Inferred from mutant phenotype	15213161	MGI
enables polysaccharide binding	IDA IDA: Inferred from direct assay	12163569	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15845454	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in antifungal innate immune response	IDA IDA: Inferred from direct assay	19136564	MGI
involved in antifungal innate immune response	IMP IMP: Inferred from mutant phenotype	17159984	MGI
involved in cell activation	IDA IDA: Inferred from direct assay	19136564	MGI
acts upstream of or within cell surface pattern recognition receptor signaling pathway	IDA IDA: Inferred from direct assay	12719478	MGI
acts upstream of or within cell-cell adhesion	IDA IDA: Inferred from direct assay	14698225	MGI
involved in cellular response to molecule of fungal origin	IDA IDA: Inferred from direct assay	15845454	MGI
involved in detection of molecule of fungal origin	IDA IDA: Inferred from direct assay	15213161	MGI
acts upstream of or within detection of yeast	IDA IDA: Inferred from direct assay	14698225	MGI
involved in detection of yeast	IDA IDA: Inferred from direct assay	19136564	MGI
involved in innate immune response	IDA IDA: Inferred from direct assay	15845454	MGI
involved in leukocyte activation involved in immune response	IDA IDA: Inferred from direct assay	15845454	MGI
acts upstream of or within phagocytosis, engulfment	IDA IDA: Inferred from direct assay	14707091	MGI
acts upstream of or within phagocytosis, recognition	IDA IDA: Inferred from direct assay	14707091	MGI
acts upstream of or within positive regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	19136564	MGI
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	19136564	MGI
involved in positive regulation of T-helper 17 type immune response	IMP IMP: Inferred from mutant phenotype	32358020	MGI
acts upstream of positive regulation of calcium-mediated signaling	IDA IDA: Inferred from direct assay	19136564	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	15213161	MGI
involved in positive regulation of cytokine production involved in immune response	IDA IDA: Inferred from direct assay	27288407	MGI
involved in positive regulation of dendritic cell cytokine production	IDA IDA: Inferred from direct assay	27288407	MGI
involved in positive regulation of dendritic cell cytokine production	IMP IMP: Inferred from mutant phenotype	19136564	MGI
involved in positive regulation of interleukin-10 production	IMP IMP: Inferred from mutant phenotype	19136564	MGI
involved in positive regulation of interleukin-2 production	IMP IMP: Inferred from mutant phenotype	19136564	MGI
involved in positive regulation of interleukin-23 production	IMP IMP: Inferred from mutant phenotype	19136564	MGI
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	19136564	MGI
involved in positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	27288407	MGI
acts upstream of or within positive regulation of phagocytosis	IDA IDA: Inferred from direct assay	14707091	MGI
involved in positive regulation of stress-activated MAPK cascade	IDA IDA: Inferred from direct assay	27288407	MGI
acts upstream of or within positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	12719478	MGI
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	19136564	MGI
acts upstream of or within regulation of calcineurin-NFAT signaling cascade	IMP IMP: Inferred from mutant phenotype	19136564	MGI
involved in regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	19136564	MGI
acts upstream of or within response to molecule of fungal origin	IDA IDA: Inferred from direct assay	12719478	MGI
acts upstream of or within response to yeast	IDA IDA: Inferred from direct assay	12719478	MGI
involved in response to yeast	IDA IDA: Inferred from direct assay	19136564	MGI
involved in stimulatory C-type lectin receptor signaling pathway	IDA IDA: Inferred from direct assay	19136564	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	12163569	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

C-type lectin domain family 7 member A

C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12	C-type lectin superfamily member 12
DC-associated C-type lectin 1	beta-glucan receptor
dectin-1	dendritic cell-associated C-type lectin 1

Recombinant Clec7a Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75296	Dectin-1/CLEC7A Protein, Mouse (HEK293, His, solution)	NP_064392.2 (F69-L244)	≥95%
HY-P700694	Dectin-1/CLEC7A Protein, Mouse (HEK293, Fc)	Q6QLQ4 (G71-L244)	≥95%

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-147295	Odetiglucan		/	Phase 3

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02800	CLEC7A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Clec7a	NCBI	NCBI:64581

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