CLEC7A - C-type lectin domain containing 7A Gene

Homo sapiens

Also known as BGR; CD369; CANDF4; SCARE2; DECTIN1; CLECSF12

Gene ID: 64581 | Gene type: protein coding

About CLEC7A

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:10,116,777-10,130,304 (from NCBI)

This gene has 13 transcripts (splice variants), 227 orthologues, 23 paralogues and is associated with 3 phenotypes. Broad expression in appendix (RPKM 22.1), bone marrow (RPKM 11.8) and 17 other tissues.

Summary

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and Plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

CLEC7A Products(6)

mRNA	Protein	Name
NM_022570.5	NP_072092.2	C-type lectin domain family 7 member A isoform b
NM_197947.3	NP_922938.1	C-type lectin domain family 7 member A isoform a
NM_197948.3	NP_922939.1	C-type lectin domain family 7 member A isoform c
NM_197949.3	NP_922940.1	C-type lectin domain family 7 member A isoform d
NM_197950.3	NP_922941.1	C-type lectin domain family 7 member A isoform e
NM_197954.3	NP_922945.1	C-type lectin domain family 7 member A isoform f

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables (1->3)-beta-D-glucan binding	IDA IDA: Inferred from direct assay	22267217	GOA
enables carbohydrate binding	IDA IDA: Inferred from direct assay	11567029	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables pattern recognition receptor activity	IDA IDA: Inferred from direct assay	11567029	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell recognition	IDA IDA: Inferred from direct assay	11567029	GOA
involved in cellular response to molecule of fungal origin	IDA IDA: Inferred from direct assay	22267217	GOA
involved in detection of fungus	IDA IDA: Inferred from direct assay	19358895	GOA
involved in detection of molecule of fungal origin	IDA IDA: Inferred from direct assay	19358895	GOA
involved in phagocytosis, recognition	IDA IDA: Inferred from direct assay	11567029	GOA
involved in positive regulation of cell maturation	IDA IDA: Inferred from direct assay	19358895	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	24721111	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	24721111	GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	22267217	GOA
involved in positive regulation of cytokine production involved in inflammatory response	IDA IDA: Inferred from direct assay	22267217	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	19358895	GOA
involved in positive regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	22267217	GOA
involved in positive regulation of interleukin-10 production	IDA IDA: Inferred from direct assay	19358895	GOA
involved in positive regulation of interleukin-12 production	IDA IDA: Inferred from direct assay	19358895	GOA
involved in positive regulation of interleukin-2 production	IDA IDA: Inferred from direct assay	19358895	GOA
involved in positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	19358895	GOA
involved in positive regulation of interleukin-8 production	IMP IMP: Inferred from mutant phenotype	25251945	GOA
involved in positive regulation of killing of cells of another organism	IDA IDA: Inferred from direct assay	19358895	GOA
involved in positive regulation of lymphocyte activation	IDA IDA: Inferred from direct assay	19358895	GOA
involved in positive regulation of monocyte chemotactic protein-1 production	IMP IMP: Inferred from mutant phenotype	25251945	GOA
involved in positive regulation of nitric oxide biosynthetic process	IDA IDA: Inferred from direct assay	19358895	GOA
involved in positive regulation of phagocytosis	IDA IDA: Inferred from direct assay	19358895	GOA
involved in positive regulation of protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	22267217	GOA
involved in positive regulation of respiratory burst	IDA IDA: Inferred from direct assay	19358895	GOA
involved in positive regulation of superoxide anion generation	IDA IDA: Inferred from direct assay	19358895	GOA
involved in positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	19358895	GOA
involved in positive regulation of type II interferon production	IDA IDA: Inferred from direct assay	19358895	GOA
involved in positive regulation of wound healing	IMP IMP: Inferred from mutant phenotype	24721111	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	24721111	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	24721111	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	25251945	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLEC7A Protein Structure

Lectin_C

0
100
200
247 a.a.

Protein Preferred Names

Protein Names

C-type lectin domain family 7 member A

C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12

Recombinant CLEC7A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70101	Dectin-1/CLEC7A Protein, Human (HEK293, Fc)	Q9BXN2 (T66-M247)	≥95%

Related Diseases

Diseases

Alias

Aspergillosis

Aspergillosis, Susceptibility To	Infection Due To Aspergillus
Aspergilloma	Aspergillus Nodule
Simple Aspergilloma	Aspergillus
Aspergillus Flavus Infection	Aspergillus Fumigatus Infection
Aspergillus Infection	Infection By Aspergillus Fumigatus
Intracavitary Aspergillus Fungus Ball	Aspergillus Terreus

Candidiasis, Familial, 4

Familial Chronic Mucocutaneous Candidiasis	CANDF4
Candidiasis, Familial Chronic Mucocutaneous	Candidiasis, Familial, 4, Autosomal Recessive
Candidiasis Familial Chronic Mucocutaneous	Chronic Mucocutaneous Candidiasis 4
Candidiasis, Familial, Type 4	Candidiasis, Familial, 2

Chronic Mucocutaneous Candidiasis

Candidiasis, Chronic Mucocutaneous	Cmc
Candidiasis Chronic Mucocutaneous

Candidiasis

Systemic Candidiasis	Invasive Candidiasis
Disseminated Candidiasis	Systemic Candida Infections
Candidiasis, Invasive

Trichosporonosis

Fungal Infectious Disease

Mycoses

Mycosis

Opportunistic Mycosis

Opportunistic Mycoses

Opportunistic Systemic Mycoses

Primary Systemic Mycosis

Vulvovaginal Candidiasis

Candidiasis Of Vulva And Vagina	Candidiasis, Vulvovaginal
Candidal Vulvovaginitis	Candidal: Cervix
Monilial Vulvovaginitis	Candidiasis Vulvovaginal

Subcutaneous Mycosis

Subcutaneous Fungal Disease

Invasive Aspergillosis

Aspergillosis Invasive

Tinea Profunda

Deep Seated Dermatophytosis	Granuloma Trichophyticum
Majocchi'S Granuloma

Dermatophytosis

Tinea	Dermatophytosis, Unspecified
Ringworm	Infections Due To Species Of Epidermophyton, Microsporum And Trichophyton
Cutaneous Mycosis	Dermal Mycosis
Superficial Mycosis, Unspecified	Fungus Infection Of Skin
Skin Mycosis	Dermatitis Fungoid
Fungal Dermatitis	Fungal Dermatosis
Mycotic Infection Of Skin

Phaeohyphomycosis

Infection By Dematiacious Fungi	Phaehyphomycosis
Phaeomycosis	Pheohyphomycosis
Infection By Dematiacious Fungi [Phaehyphomycosis]	Dematiaceous Fungal Infection

Vaginal Disease

Vaginal Diseases

Tinea Corporis

Dermatophytosis Of The Body

Dermatophytosis Of The Trunk

Coccidioidomycosis

Valley Fever	Primary Extrapulmonary Coccidioidomycosis
Coccidioides Immitis Infection	Coccidiosis
Coccidioides Infection	Coccidioidomycosis, Unspecified
San Joaquin Fever	California Disease
Desert Fever	Desert Rheumatism
San Joaquin Valley Fever	Enteric Coccidiosis
Primary Pulmonary Coccidioidomycosis	Acute Coccidioidomycosis
Posadas Wernicke Disease

Blastomycosis

Gilchrist'S Disease	North American Blastomycosis
Blastomyces Dermatitidis Infection	Blastomycotic Infection
Infection By Blastomyces Dermatitidis	Gilchrist Disease
Chicago Disease	Chicago Disease Or Disorder
Blastomycosis, Unspecified	Blastomyces Infection

Nail Disease

Nail Diseases	Abnormality Of The Nail
Nail Anomaly

Tinea Pedis

Athlete'S Foot	Dermatophytosis Of Foot
Ringworm Of Foot	Moccasin Foot

Superficial Mycosis

Piedra

Steroid-Modified Tinea Infection

Neonatal Candidiasis

Neonatal Candida Infection	Neonatal Monilia Infection
Neonatal Moniliasis

Pneumocystosis

Pneumocystis Jirovecii Pneumonia	Pneumocystis Carinii Pneumonia
Pneumocystis Pneumonia	Pulmonary Pneumocystosis
PCP	Pneumocystosis Pneumonia
Pneumonia Pneumocystis Carinii	Pneumonia, Pneumocystis
Pneumocystis Jiroveci Pneumonia

Chromoblastomycosis

Chromomycosis	Mossy Foot Disease
Verrucous Dermatitis	Fonseca Disease
Pedroso Disease	Drechslera Hawaiiensis
Drechslera Infection

Sporotrichosis

Rose Gardener'S Disease

Cutaneous Candidiasis

Candidiasis, Cutaneous

Denture Stomatitis

Stomatitis, Denture

Denture Sore Mouth

Penicilliosis

Tinea Imbricata

Kerion Celsi	Trichophyton Infection
Tinea Imbricata, Susceptibility To	Susceptibility To Tinea Imbricata
Tinea Capitis Profunda	Trichophytia Profunda Barbae
Trichophytia Profunda Capitis	Tinea Capitis

Tinea Capitis

Dermatophytosis Of Scalp	Scalp Ringworm
Dermatophytosis Of Scalp Or Beard	Tinea Capitis Due To Trichophyton Rubrum
Trichophyton Rubrum Tinea Capitis

White Piedra

Tinea Blanca

Trichosporosis Nodosa

Cryptococcosis

Cryptococcus Neoformans Infection	Torulosis
Busse-Buschke'S Disease	Cryptococcal Infection
European Cryptococcosis	Torula
Infection By Cryptococcus Neoformans	Cryptococcosis Infection
European Blastomycosis	European Blastomycotic Infection
European Blastomycoses Infection	Torula Histolytica Infection

Oral Candidiasis

Thrush	Candidiasis Of Mouth
Oral Moniliasis	Thrush, Oral
Candidiasis, Oral	Oral Thrush
Candidiasis	Equine Thrush

Mucormycosis

Zygomycosis	Disseminated Mucormycosis
Absidia Infection	Absidia Mucoromycosis
Cunninghamella Infection	Cunninghamella Mucoromycosis
Infection By Absidia Spp	Infection By Rhizopus Spp
Mucor Infection	Mucor Mucoromycosis
Infection By Mucor Spp	Rhizopus Infection
Rhizopus Mucoromycosis	Infection By Cunninghamella Spp
Phycomycosis Nos

Allergic Bronchopulmonary Aspergillosis

Aspergillosis, Allergic Bronchopulmonary	Abpa
Allergic Bronchopulmonary Mycosis	Hinson-Pepys Disease
Pulmonary Aspergillus Disease	Allergic Aspergillosis
Aspergillosis Allergic Bronchopulmonary

Pityriasis Versicolor

Tinea Versicolor

Infection By Pityrosporum Furfur

Histoplasmosis

Darling Disease	Reticuloendotheliosis, X-Linked
Infection By Histoplasma Capsulatum	Histoplasma Infection
Reticuloendothelial Cytomycosis	Cytomycosis
Darling Histoplasmosis	African Histoplasmosis
Histoplasmosis Duboisii

Hyper Ige Recurrent Infection Syndrome 1

Job Syndrome	Hyper-Ige Recurrent Infection Syndrome 1
Hyperimmunoglobulin E Syndrome	Job'S Syndrome
Recurring Cold Staphylococcal Abscesses	Ige Syndromes
Buckley Syndrome	Hie - [Hyperimmunoglobulin E] Syndrome
Job-Buckley Syndrome	Quie-Hill Syndrome

Fungal Meningitis

Meningitis, Fungal

Mycotic Meningitis

Autoimmune Polyendocrine Syndrome Type 1

Whitaker Syndrome	Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy
Autoimmune Polyglandular Syndrome I	Polyglandular Type I Autoimmune Syndrome

Autoimmune Polyendocrine Syndrome

Autoimmune Polyendocrinopathy	Autoimmune Polyglandular Failure
Autoimmune Polyglandular Syndrome	Polyendocrinopathies, Autoimmune
Lloyd'S Syndrome	Aps
Polyendocrinopathies Autoimmune	Polyendocrine Autoimmunity Syndrome
Lloyd Syndrome	Polyglandular Autoimmune Deficiency
Progressive Pluriglandular Insufficiency	Pluriglandular Autoimmune Atrophy
Pluriglandular Autoimmune Syndrome	Thyroid-Adrenocortical Insufficiency Syndrome

Neuroaspergillosis

Fusariosis

Fusarium Infection

Vulvovaginitis

Vulvo-Vaginitis

Cryptococcal Meningitis

Meningitis, Cryptococcal

Meningitis Cryptococcal

Esophageal Candidiasis

Candidiasis Of The Esophagus	Candida Esophagitis
Candidal Esophagitis	Esophageal Moniliasis
Esophageal Thrush

Corneal Ulcer

Cornea Ulcer	Ulcerative Keratitis
Corneal Ulcer Nos

Mycobacterium Tuberculosis 1

Tuberculosis	Tuberculoma
Tuberculosis, Susceptibility To	Mycobacterium Tuberculosis, Susceptibility To, 1
Mtbs1	TB

Hyper Ige Syndrome

Hyper-Ige Syndrome	Hyper Immunoglobulin E Syndrome
Hies	Hyper-Ige Recurrent Infection Syndrome
Hyperimmunoglobulin E Syndrome	Hyper Ige
Job Syndrome	Hartnup Disease

Chronic Granulomatous Disease

Cgd	Granulomatous Disease, Chronic
Autosomal Recessive Chronic Granulomatous Disease	X-Linked Chronic Granulomatous Disease
Bridges-Good Syndrome	Congenital Dysphagocytosis
Quie Syndrome	Chronic Septic Granulomatosis
Chronic Granulomatous Disorder	Granulomatous Disease Chronic
Granulomatous Disease, Chronic, X-Linked

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-147295	Odetiglucan		/	Phase 3

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02800	CLEC7A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CLEC7A	VGNC	VGNC:97753
Mus musculus	CLEC7A	MGD	MGI:1861431
Felis catus	CLEC7A	VGNC	VGNC:60955
Rattus norvegicus	CLEC7A	RGD	RGD:1565140
Bos taurus	CLEC7A	VGNC	VGNC:58597
Canis familiaris	CLEC7A	VGNC	VGNC:39335
Others	CLEC7A	NCBI