EMC7 - ER membrane protein complex subunit 7 Gene

Homo sapiens

Also known as HT022; C11orf3; C15orf24; ORF1-FL1

Gene ID: 56851 | Gene type: protein coding

About EMC7

This gene has 4 transcripts (splice variants) and 208 orthologues. Ubiquitous expression in testis (RPKM 46.7), adrenal (RPKM 45.9) and 25 other tissues.

Summary

Contributes to membrane insertase activity. Involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Is integral component of endoplasmic reticulum membrane. Part of EMC complex. [provided by Alliance of Genome Resources, Apr 2022]

EMC7 Products(1)

mRNA	Protein	Name
NM_020154.3	NP_064539.1	ER membrane protein complex subunit 7 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to membrane insertase activity	IMP IMP: Inferred from mutant phenotype	29809151	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence	IDA IDA: Inferred from direct assay	29242231	GOA
involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence	IMP IMP: Inferred from mutant phenotype	29809151	GOA
involved in tail-anchored membrane protein insertion into ER membrane	IDA IDA: Inferred from direct assay	29242231	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of EMC complex	IDA IDA: Inferred from direct assay	22119785	GOA
part of EMC complex	IPI IPI: Inferred from physical interaction	32439656	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	32439656	GOA
located in membrane	IDA IDA: Inferred from direct assay	22119785	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EMC7 Protein Structure

DUF2012

0
100
200
242 a.a.

Protein Preferred Names

Protein Names

ER membrane protein complex subunit 7

UPF0480 protein C15orf24

EMC7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EMC7	Q9NPA0	KRTAP5-2	Homo sapiens	Q701N4	Y2H Prey Pooling	32296183
Intra	EMC7	Q9NPA0	KRTAP5-2	Homo sapiens	Q701N4	Y2H Array	32296183
Intra	EMC7	Q9NPA0	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	EMC7	Q9NPA0	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	EMC7	Q9NPA0	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	EMC7	Q9NPA0	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	EMC7	Q9NPA0	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	EMC7	Q9NPA0	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	EMC7	Q9NPA0	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	EMC7	Q9NPA0	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	EMC7	Q9NPA0	KRTAP5-9	Homo sapiens	P26371	Y2H Array	32296183
Intra	EMC7	Q9NPA0	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Nodular Hidradenoma

Eccrine Nodular Hidradenoma

Eccrine Acrospiroma

Acrospiroma	Poroma
Eccrine Hidradenoma	Eccrine Hidradenoma Of Skin
Hidradenoma	Adenoma, Sweat Gland
Benign Neoplasm Of Sweat Gland	Eccrine Poroma

Eccrine Sweat Gland Neoplasm

Eccrine Skin Neoplasm	Eccrine Tumor
Eccrine Neoplasm	Malignant Eccrine Neoplasm

Hidradenoma

Adenoma, Sweat Gland	Hidradenoma Of Skin
Sweat Gland Adenoma	Syringoadenoma
Eccrine Acrospiroma	Benign Neoplasm Of Sweat Gland

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04341	EMC7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	EMC7	MGD	MGI:1920274
Canis familiaris	EMC7	VGNC	VGNC:40336
Bos taurus	EMC7	VGNC	VGNC:55112
Rattus norvegicus	EMC7	RGD	RGD:1305045
Felis catus	EMC7	VGNC	VGNC:61837
Macaca mulatta	EMC7	VGNC	VGNC:72094

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