NCLN - nicalin Gene

Homo sapiens

Also known as NET59

Gene ID: 56926 | Gene type: protein coding

About NCLN

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:3,185,930-3,209,575 (from NCBI)

This gene has 8 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in colon (RPKM 14.1), duodenum (RPKM 12.9) and 25 other tissues.

Summary

Enables ribosome binding activity. Involved in protein stabilization; regulation of protein complex stability; and regulation of protein-containing complex assembly. Located in endoplasmic reticulum membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

NCLN Products(2)

mRNA	Protein	Name
NM_001321463.2	NP_001308392.1	nicalin isoform 2 precursor
NM_020170.4	NP_064555.2	nicalin isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17261586	GOA
enables ribosome binding	IDA IDA: Inferred from direct assay	32820719	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in multi-pass transmembrane protein insertion into ER membrane	IDA IDA: Inferred from direct assay	36261522	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	20538592	GOA
involved in regulation of protein complex stability	IDA IDA: Inferred from direct assay	20538592	GOA
involved in regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	20538592	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	20538592	GOA
part of multi-pass translocon complex	IDA IDA: Inferred from direct assay	36261522	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	20538592	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NCLN Protein Structure

Peptidase_M28

0
100
200
300
400
500
563 a.a.

Protein Preferred Names

Protein Names

nicalin

nicalin homolog

Related Diseases

Diseases

Alias

Hirschsprung Disease 1

Hirschsprung Disease	Aganglionic Megacolon
Hscr	Hirschsprung'S Disease
Congenital Megacolon	Congenital Intestinal Aganglionosis
Colonic Aganglionosis	Hirschsprung Disease, Susceptibility To, 1
Hirschsprung Disease, Protection Against	HSCR1
Mgc	Pelvirectal Achalasia
Total Intestinal Aganglionosis	Megacolon, Aganglionic
Macrocolon	Hscr 1
Hirschsprung Disease Type 1	Hirschsprung Disease, Type 1
Congenital Dilatation Of Colon	Aganglionosis
Congenital Aganglionic Megacolon	Aganglionosis Of Colon
Bowel Aganglionosis	Colon Aganglionosis
Hirschsprung Megacolon

Lissencephaly 4

LIS4	Lissencephaly 4 With Microcephaly
Microlissencephaly	Lissencephaly, Type 4

Janus Kinase-3 Deficiency

Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 1

Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome	Berdon Syndrome
MMIHS	Megacystis Microcolon Intestinal Hypoperistalsis Syndrome
Megacystis, Microcolon, Hypoperistalsis Syndrome	Visceral Myopathy
Mmih Syndrome	Megacystis-Microcolon-Intestinal Hypoperistalsis-Hydronephrosis Syndrome
MMIHS1	Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome, Mmih
Mmhs

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09087	NCLN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NCLN	RGD	RGD:1309355
Felis catus	NCLN	VGNC	VGNC:80632
Mus musculus	NCLN	MGD	MGI:1926081
Bos taurus	NCLN	VGNC	VGNC:31919
Macaca mulatta	NCLN	VGNC	VGNC:75032
Canis familiaris	NCLN	VGNC	VGNC:43658

Name
Email *

	Sorry, but the email address you supplied was invalid.