PARP11 - poly(ADP-ribose) polymerase family member 11 Gene

Homo sapiens

Also known as ARTD11; MIB006; C12orf6

Gene ID: 57097 | Gene type: protein coding

About PARP11

Cytogenetic location: 12p13.32 Genomic coordinates (GRCh38): 12:3,808,861-3,873,399 (from NCBI)

This gene has 8 transcripts (splice variants), 259 orthologues and 8 paralogues. Ubiquitous expression in prostate (RPKM 3.6), testis (RPKM 3.6) and 25 other tissues.

Summary

Enables NAD+ ADP-ribosyltransferase activity and protein ADP-ribosylase activity. Involved in protein auto-ADP-ribosylation and protein mono-ADP-ribosylation. Located in cytosol; nuclear body; and nuclear envelope. [provided by Alliance of Genome Resources, Apr 2022]

PARP11 Products(3)

mRNA	Protein	Name
NM_001286521.2	NP_001273450.1	protein mono-ADP-ribosyltransferase PARP11 isoform b
NM_001286522.2	NP_001273451.1	protein mono-ADP-ribosyltransferase PARP11 isoform b
NM_020367.6	NP_065100.2	protein mono-ADP-ribosyltransferase PARP11 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables NAD+-protein ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	25043379	GOA
enables NAD+-protein poly-ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	25673562	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein auto-ADP-ribosylation	IDA IDA: Inferred from direct assay	25043379	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nuclear envelope	IDA IDA: Inferred from direct assay	25673562	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PARP11 Protein Structure

WWE

PARP

0
100
200
300
338 a.a.

Protein Preferred Names

Protein Names

protein mono-ADP-ribosyltransferase PARP11

ADP-ribosyltransferase diphtheria toxin-like 11

Related Diseases

Diseases

Alias

Osteogenesis Imperfecta, Type Xx

OI20	Osteogenesis Imperfecta Type 20
Osteogenesis Imperfecta, Type 20	Osteogenesis Imperfecta Type Xx
Osteogenesis Imperfecta 20

Arthrogryposis, Renal Dysfunction, And Cholestasis 1

Arc Syndrome	ARCS1
Arthrogryposis Renal Dysfunction Cholestasis Syndrome	Arthrogryposis-Renal Dysfunction-Cholestasis Syndrome
Arcs	Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome
Arthrogryposis, Renal Dysfunction, And Cholestasis	Arthrogryposis-Renal Dysfunction-Cholestasis
Arthrogryposis - Renal Dysfunction - Cholestasis	Arthrogryposis Multiplex Congenita, Renal Dysfunction, And Cholestasis
Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome 1	Arthrogryposis Renal Dysfunction And Cholestasis 1
Arthrogryposis With Renal Dysfunction And Cholestasis Syndrome	Arthrogryposis, Renal Dysfunction, Cholestasis, Type 1
Kidney Failure	Renal Insufficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125218	PARP11 inhibitor ITK7	Inhibitor	99.77%	Unkown
HY-148566	OUL232	Inhibitor	99.86%	Unkown
HY-RS10053	PARP11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PARP11	MGD	MGI:2141505
Rattus norvegicus	PARP11	RGD	RGD:1561791
Bos taurus	PARP11	VGNC	VGNC:49073

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