2. Cell Cycle/DNA Damage Epigenetics
  3. PARP
  4. PARP11 inhibitor ITK7

PARP11 inhibitor ITK7  (Synonyms: ITK7)

Cat. No.: HY-125218 Purity: 99.77%
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PARP11 inhibitor ITK7 (ITK7) is a potent and selective PARP11 inhibitor. PARP11 inhibitor ITK7 can potently inhibit PARP11 with an IC50 value of 14 nM. PARP11 inhibitor ITK7 can be used for the research of cellular localization.

For research use only. We do not sell to patients.

PARP11 inhibitor ITK7 Chemical Structure

PARP11 inhibitor ITK7 Chemical Structure

CAS No. : 2411890-36-1

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5 mg USD 380 In-stock
10 mg USD 620 In-stock
25 mg USD 1250 In-stock
50 mg USD 2000 In-stock
100 mg USD 3200 In-stock
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Based on 1 publication(s) in Google Scholar

PARP11 inhibitor ITK7 Related Antibodies

Top Publications Citing Use of Products

View All PARP Isoform Specific Products:

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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  • Purity & Documentation

  • References

  • Customer Review

Description

PARP11 inhibitor ITK7 (ITK7) is a potent and selective PARP11 inhibitor. PARP11 inhibitor ITK7 can potently inhibit PARP11 with an IC50 value of 14 nM. PARP11 inhibitor ITK7 can be used for the research of cellular localization[1].

IC50 & Target

IC50: 14 nM (PARP11); 13 nM (PARP11-dependent auto-MARylation)[1]
In Vitro

PARP11 inhibitor ITK7 (ITK7) can potently inhibit PARP11 with an IC50 value of 14 nM[1].
ITK7 exhibits a dose-dependent inhibition of PARP11-dependent auto-MARylation with an EC50 value of 13 nM[1].
ITK7 (0, 0.03, 0.1, 0.3, 1, 3 μM; 3 h) inhibits PARP11 auto-MARylation activity in cells and causes PARP11 to dissociate from the nuclear envelope[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PARP11 inhibitor ITK7 Related Antibodies

Western Blot Analysis[1]

Cell Line: HeLa cells
Concentration: 0, 0.03, 0.1, 0.3, 1, 3 μM
Incubation Time: 3 h
Result: Inhibited GFP-PARP11 auto-MARylation activity in a dose-dependent manner in HeLa cells.
Molecular Weight

322.38

Formula

C17H14N4OS
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1NC(CSC2=NC=CC=N2)=NC3=C1C=CC(C#CC)=C3C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 4 mg/mL (12.41 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1019 mL 15.5096 mL 31.0193 mL
5 mM 0.6204 mL 3.1019 mL 6.2039 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  0.5% CMC-Na/saline water

    Solubility: 5 mg/mL (15.51 mM); Suspended solution; Need ultrasonic

  • Protocol 2

    Add each solvent one by one:  15% Cremophor EL    85% Saline

    Solubility: 10 mg/mL (31.02 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1019 mL 15.5096 mL 31.0193 mL 77.5482 mL
5 mM 0.6204 mL 3.1019 mL 6.2039 mL 15.5096 mL
10 mM 0.3102 mL 1.5510 mL 3.1019 mL 7.7548 mL
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PARP11 inhibitor ITK7 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PARP11 inhibitor ITK72411890-36-1ITK7ITK 7ITK-7PARPpoly ADP ribose polymeraseADP-ribosylationMARylationPARP11PARPsnuclear envelopecellular localizationInhibitorinhibitorinhibit

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