TIGAR - TP53 induced glycolysis regulatory phosphatase Gene

Homo sapiens

Also known as FR2BP; C12orf5

Gene ID: 57103 | Gene type: protein coding

About TIGAR

Cytogenetic location: 12p13.32 Genomic coordinates (GRCh38): 12:4,321,213-4,360,028 (from NCBI)

This gene has 4 transcripts (splice variants) and 108 orthologues. Ubiquitous expression in urinary bladder (RPKM 2.3), colon (RPKM 2.2) and 24 other tissues.

Summary

This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic Enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging Reactive Oxygen Species and provides some protection from DNA damage-induced Apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq, Jul 2008]

TIGAR Products(1)

mRNA	Protein	Name
NM_020375.3	NP_065108.1	fructose-2,6-bisphosphatase TIGAR

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables fructose-2,6-bisphosphate 2-phosphatase activity	EXP EXP: Inferred from Experiment	16839880	GOA
enables fructose-2,6-bisphosphate 2-phosphatase activity	IDA IDA: Inferred from direct assay	19015259	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23185017	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	25928429	GOA
involved in cellular response to cobalt ion	IDA IDA: Inferred from direct assay	25928429	GOA
involved in cellular response to hypoxia	IDA IDA: Inferred from direct assay	23185017	GOA
involved in negative regulation of programmed cell death	IDA IDA: Inferred from direct assay	23185017	GOA
involved in positive regulation of DNA repair	IMP IMP: Inferred from mutant phenotype	25928429	GOA
involved in positive regulation of hexokinase activity	IDA IDA: Inferred from direct assay	23185017	GOA
involved in regulation of pentose-phosphate shunt	IMP IMP: Inferred from mutant phenotype	25928429	GOA
involved in regulation of response to DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	25928429	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	23185017	GOA
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	23185017	GOA
located in nucleus	IDA IDA: Inferred from direct assay	25928429	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TIGAR Protein Structure

His_Phos_1

0
100
200
270 a.a.

Protein Preferred Names

Protein Names

fructose-2,6-bisphosphatase TIGAR

TP53-induced glycolysis and apoptosis regulator

TIGAR Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TIGAR	Q9NQ88	HK2	Homo sapiens	P52789	Anti Bait CoIP	23185017
Intra	TIGAR	Q9NQ88	HK2	Homo sapiens	P52789	Anti Tag CoIP	23185017

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hemangioma Of Spleen

Splenic Hemangioma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1925A	GO-203 TFA		99.28%	Unkown
HY-RS14523	TIGAR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TIGAR	MGD	MGI:2442752
Rattus norvegicus	TIGAR	RGD	RGD:1560038
Canis familiaris	TIGAR	VGNC	VGNC:47368
Bos taurus	TIGAR	VGNC	VGNC:35863
Macaca mulatta	TIGAR	VGNC	VGNC:78374

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