2. Recombinant Proteins
  3. Immune Checkpoint Proteins
  4. Inhibitory Checkpoint Molecules
  5. TIGIT Protein

TIGIT Protein

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T cell immunoglobulin and ITIM domain (TIGIT), also called WUCAM, Vstm3 and VSIG9, is a 244-amino acid transmembrane glycoprotein that expressed by lymphocytes, particularly in effector and regulatory CD4+ T cells, follicular helper CD4+ T cells, effective CD8+ T cells and NK cells. TIGIT is a member of the CD28 family and functions as a co-inhibitory receptor. TIGIT consists of one extracellular immunoglobulin variable region (IgV), a transmembrane domain and a short intracellular domain with one immunoreceptor tyrosine-based inhibitory motif (ITIM) and one immunoglobulin tyrosine tail (ITT)-like motif. TIGIT binds to CD155 (PVR, Necl5 or Tage4) with a high-affinity and also to CD112 (PVRL2 or nectin 2) and CD113 (PVRL3) with lower affinity. TIGIT potently inhibits innate and adaptive immunity through multiple mechanisms and is crucial for balancing T cell activation and for protection from autoimmunity.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P71363
    TIGIT Protein, Human (HEK293, mFc)

    T-cell immunoreceptor with Ig and ITIM domains; ; VSIG9; VSTM3; TIGIT; V-set and transmembrane domain-containing protein 3; V-set and immunoglobulin domain-containing protein 9

    		Human HEK293
    The TIGIT protein plays a key role in immune regulation and binds with high affinity to the poliovirus receptor (PVR). This interaction induces an immunosuppressive environment by increasing IL10 secretion and decreasing IL12B secretion. TIGIT Protein, Human (HEK293, mFc) is the recombinant human-derived TIGIT protein, expressed by HEK293 , with C-mFc labeled tag.
  • HY-P7414
    TIGIT Protein, Human (HEK293, Fc)

    rHuTIGIT, Fc Chimera; VSIG9; VSTM3; T Cell Immunoreceptor with Ig and ITIM Domains

    		Human HEK293
    TIGIT Protein, Human (HEK293, Fc) produced in HEK293 cells with the C-termimal human IgG1 Fc fragment. T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3). It belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM).
  • HY-P70624
    TIGIT Protein, Human (HEK293, His)

    T-cell immunoreceptor with Ig and ITIM domains; ; VSIG9; VSTM3; TIGIT; V-set and transmembrane domain-containing protein 3; V-set and immunoglobulin domain-containing protein 9

    		Human HEK293
    The TIGIT protein plays a key role in immune regulation and binds with high affinity to the poliovirus receptor (PVR). This interaction induces an immunosuppressive environment by increasing IL10 secretion and decreasing IL12B secretion. TIGIT Protein, Human (HEK293, His) is the recombinant human-derived TIGIT protein, expressed by HEK293 , with C-6*His labeled tag.
  • HY-P77235
    TIGIT Protein, Mouse (HEK293, mFc)

    T cell immunoreceptor with Ig and ITIM domains; TIGIT; VSIG9; VSTM3

    		Mouse HEK293
    TIGIT protein, with signaling receptor binding activity, functions upstream of T cell activation suppression. Active on the cell surface, it shares orthology with human TIGIT. Associated with modulating T cell responses, TIGIT exhibits biased expression, notably in the large intestine, small intestine, and other tissues. This highlights its potential in immune regulation within these contexts. TIGIT Protein, Mouse (HEK293, mFc) is the recombinant mouse-derived TIGIT protein, expressed by HEK293 , with C-mFc labeled tag. The total length of TIGIT Protein, Mouse (HEK293, mFc) is 125 a.a., with molecular weight of ~39-52 KDa.
  • HY-P78602
    TIGIT Protein, Rabbit (HEK293, Fc)

    TIGIT; VSIG9; VSTM3

    		Rabbit HEK293
    The TIGIT protein plays a key role in immune regulation and binds with high affinity to the poliovirus receptor (PVR). This interaction induces an immunosuppressive environment by increasing IL10 secretion and decreasing IL12B secretion. TIGIT Protein, Rabbit (HEK293, Fc) is the recombinant Rabbit-derived TIGIT protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TIGIT Protein, Rabbit (HEK293, Fc) is 127 a.a., with molecular weight of 45-55 kDa.
  • HY-P70677
    TIGIT Protein, Cynomolgus (HEK293, His)

    T-cell immunoreceptor with Ig and ITIM domains; VSIG9; VSTM3; TIGIT; V-set and transmembrane domain-containing protein 3; V-set and immunoglobulin domain-containing protein 9

    		Cynomolgus HEK293
    Ig-like domain-containing protein is a class of proteins that may be involved in protein–protein and protein–ligand interactions, therefore being involved in biological processes such as down-regulation of T cell activation or cardiac and neuronal development. TIGIT Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived TIGIT protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TIGIT Protein, Cynomolgus (HEK293, His) is 121 a.a., with molecular weight of 16-30 kDa.
  • HY-P72449
    TIGIT Protein, Mouse (110a.a, HEK293, His)

    T-cell immunoreceptor with Ig and ITIM domains; TIGIT; V-set and transmembrane domain-containing protein 3; VSTM3

    		Mouse HEK293
    TIGIT protein, with signaling receptor binding activity, functions upstream of T cell activation suppression. Active on the cell surface, it shares orthology with human TIGIT. Associated with modulating T cell responses, TIGIT exhibits biased expression, notably in the large intestine, small intestine, and other tissues. This highlights its potential in immune regulation within these contexts. TIGIT Protein, Mouse (110a.a, HEK293, His) is the recombinant mouse-derived TIGIT protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TIGIT Protein, Mouse (110a.a, HEK293, His) is 110 a.a., with molecular weight of 15-22 kDa.
  • HY-P74513
    TIGIT Protein, Rat (HEK293, Fc)

    T cell immunoreceptor with Ig and ITIM domains; TIGIT; VSIG9; VSTM3

    		Rat HEK293
    T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins, binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation or T cell dependent B cell responses by promoting the generation of mature immunoregulatory dendritic cells. TIGIT Protein, Rat (HEK293, Fc) is the recombinant rat-derived TIGIT protein, expressed by HEK293 , with C-hFc labeled tag.
  • HY-P78216
    TIGIT Protein, Human (Biotinylated, HEK293, His-Avi)

    TIGIT; VSIG9; VSTM3; WUCAM

    		Human HEK293
    The TIGIT protein plays a key role in immune regulation and binds with high affinity to the poliovirus receptor (PVR). This interaction induces an immunosuppressive environment by increasing IL10 secretion and decreasing IL12B secretion. TIGIT Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived TIGIT protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
  • HY-P71007
    TIGIT Protein, Cynomolgus (HEK293, C-hFc)

    T-cell immunoreceptor with Ig and ITIM domains; VSIG9; VSTM3; TIGIT; V-set and transmembrane domain-containing protein 3; V-set and immunoglobulin domain-containing protein 9

    		Cynomolgus HEK293
    Ig-like domain-containing protein is a class of proteins that may be involved in protein–protein and protein–ligand interactions, therefore being involved in biological processes such as down-regulation of T cell activation or cardiac and neuronal development. TIGIT Protein, Cynomolgus (HEK293, C-hFc) is the recombinant cynomolgus-derived TIGIT protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TIGIT Protein, Cynomolgus (HEK293, C-hFc) is 121 a.a., with molecular weight of 45-55 kDa.
  • HY-P72418
    TIGIT Protein, Human (HEK293, His-Avi)

    T-cell immunoreceptor with Ig and ITIM domains; VSIG9; VSTM3

    		Human HEK293
    The TIGIT protein plays a key role in immune regulation and binds with high affinity to the poliovirus receptor (PVR). This interaction induces an immunosuppressive environment by increasing IL10 secretion and decreasing IL12B secretion. TIGIT Protein, Human (HEK293, His-Avi) is the recombinant human-derived TIGIT protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag. The total length of TIGIT Protein, Human (HEK293, His-Avi) is 120 a.a., with molecular weight of 17-23 kDa.
  • HY-P76674
    TIGIT Protein, Cynomolgus (HEK293, Fc)

    T cell immunoreceptor with Ig and ITIM domains; TIGIT; VSIG9; VSTM3

    		Cynomolgus HEK293
    TIGIT is a receptor of the Ig superfamily that plays a key role in restricting adaptive and innate immunity. TIGIT can be used as an immune modulator to inhibit the activity of T cells and NK cells, and also regulates the recognition of cancer cells. TIGIT consists of an extracellular immunoglobulin (Ig) variable domain, a type 1 transmembrane domain, and a cytoplasmic tail with two inhibitory motifs. TIGIT Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived TIGIT protein, expressed by HEK293 , with C-hFc labeled tag.
  • HY-P71009
    TIGIT Protein, Mouse (118a.a, HEK293, Fc)

    T-cell immunoreceptor with Ig and ITIM domains; Tigit

    		Mouse HEK293
    TIGIT protein, with signaling receptor binding activity, functions upstream of T cell activation suppression. Active on the cell surface, it shares orthology with human TIGIT. Associated with modulating T cell responses, TIGIT exhibits biased expression, notably in the large intestine, small intestine, and other tissues. This highlights its potential in immune regulation within these contexts. TIGIT Protein, Mouse (118a.a, HEK293, Fc) is the recombinant mouse-derived TIGIT protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TIGIT Protein, Mouse (118a.a, HEK293, Fc) is 118 a.a., with molecular weight of 50-60 kDa.
Cat. No. Product Name Effect Purity