2. Gene
  3. CYSLTR2 - cysteinyl leukotriene receptor 2 Gene

CYSLTR2 - cysteinyl leukotriene receptor 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HG57; CYSLT2; GPCR21; HPN321; CYSLT2R; KPG_011; hGPCR21; PSEC0146

Gene ID: 57105 | Gene type: protein coding

About CYSLTR2

Cytogenetic location: 13q14.2 Genomic coordinates (GRCh38): 13:48,653,929-48,711,226 (from NCBI)

This gene has 6 transcripts (splice variants), 80 orthologues, 16 paralogues and is associated with 53 phenotypes. Broad expression in placenta (RPKM 7.8), heart (RPKM 2.8) and 17 other tissues.

Summary

The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems. [provided by RefSeq, Jul 2008]

CYSLTR2 Products(11)

mRNA Protein Name
NM_001308476.3 NP_001295405.1 cysteinyl leukotriene receptor 2
NM_020377.5 NP_065110.1 cysteinyl leukotriene receptor 2
NM_001387013.1 NP_001373942.1 cysteinyl leukotriene receptor 2
NM_001308465.3 NP_001295394.1 cysteinyl leukotriene receptor 2
NM_001308468.3 NP_001295397.1 cysteinyl leukotriene receptor 2
NM_001308467.3 NP_001295396.1 cysteinyl leukotriene receptor 2
NM_001387014.1 NP_001373943.1 cysteinyl leukotriene receptor 2
NM_001308469.3 NP_001295398.1 cysteinyl leukotriene receptor 2
NM_001308471.3 NP_001295400.1 cysteinyl leukotriene receptor 2
NM_001308470.3 NP_001295399.1 cysteinyl leukotriene receptor 2
NM_001387012.1 NP_001373941.1 cysteinyl leukotriene receptor 2
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
21525870 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CYSLTR2 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (55 - 305)

  • 0
  • 100
  • 200
  • 300
  • 346 a.a.
Protein Preferred Names Protein Names

cysteinyl leukotriene receptor 2

G-protein coupled receptor GPCR21

G-protein coupled receptor HG57

cysteinyl leukotriene CysLT2 receptor

CYSLTR2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CYSLTR2 Q9NS75 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra
CYSLTR2 Q9NS75 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra
CYSLTR2 Q9NS75 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra
CYSLTR2 Q9NS75 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
CYSLTR2 Q9NS75 DLG1 Homo sapiens Q12959
TAP
26617989
Intra
CYSLTR2 Q9NS75 DLG1 Homo sapiens Q12959
Ub Reconstruction
21525870
Intra
CYSLTR2 Q9NS75 LNX1 Homo sapiens Q8TBB1
Y2H Array
32296183
Intra
CYSLTR2 Q9NS75 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Conjunctival Cancer

Malignant Neoplasm Of Conjunctiva

Conjunctival Neoplasms

Conjunctival Tumor

Malignant Conjunctival Tumor

Malignant Tumor Of Conjunctiva

Neoplasm Of Conjunctiva

Conjunctiva Cancer

Primary Malignant Neoplasm Of Conjunctiva
Melanoma, Uveal

Uveal Melanoma

Choroidal Melanoma

Melanoma Of Uvea

Iris Melanoma

Malignant Melanoma Of Choroid

Malignant Melanoma Of Iris
Malignant Conjunctival Melanoma

Conjunctival Melanoma

Malignant Melanoma Of Conjunctiva

Conjunctival Malignant Melanoma
Vernal Conjunctivitis

Conjunctivitis Vernal

Conjunctivitis, Vernal
Asthma, Nasal Polyps, And Aspirin Intolerance

Asthma And Nasal Polyps

Asa Triad

Asthma, Aspirin-Induced, Susceptibility To

Asthma, Aspirin-Induced

Asthma, With Nasal Polyps And Aspirin Intolerance

ANPAI

Aia

Aspirin-Intolerant Asthma

Asthma Aspirin-Induced

Nasal Polyps Asthma And Aspirin Sensitivity

Samter Triad

Asthma With Aspirin Triad Including Nonsteroidal Anti-Inflammatory Activity And Nasal Polyps
Aspirin-Induced Respiratory Disease

Aspirin-Sensitive Asthma
Persistent Mild Asthma
Exercise-Induced Bronchoconstriction

Exercise-Induced Asthma

Asthma Exercise-Induced
Ocular Melanoma

Intraocular Melanoma

Uveal Melanoma

Eye Melanoma

Melanoma Of Eye

Melanoma Of The Uvea

Malignant Melanoma Of Eye
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus
Uveal Disease

Uveal Diseases
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03497 CYSLTR2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS03498 Cysltr2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS03499 Cysltr2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CYSLTR2 MGD MGI:1917336
Bos taurus CYSLTR2 VGNC VGNC:50271
Macaca mulatta CYSLTR2 VGNC VGNC:106256
Rattus norvegicus CYSLTR2 RGD RGD:619797
Canis familiaris CYSLTR2 VGNC VGNC:57504