RAB25 - RAB25, member RAS oncogene family Gene

Homo sapiens

Also known as CATX-8; RAB11C

Gene ID: 57111 | Gene type: protein coding

About RAB25

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:156,061,160-156,070,504 (from NCBI)

This gene has 5 transcripts (splice variants), 265 orthologues and 68 paralogues. Biased expression in esophagus (RPKM 128.3), skin (RPKM 60.6) and 12 other tissues.

Summary

The protein encoded by this gene is a member of the Ras superfamily of small GTPases. The encoded protein is involved in membrane trafficking and cell survival. This gene has been found to be a tumor suppressor and an oncogene, depending on the context. Two variants, one protein-coding and the Other not, have been found for this gene. [provided by RefSeq, Nov 2015]

RAB25 Products(1)

mRNA	Protein	Name
NM_020387.4	NP_065120.2	ras-related protein Rab-25 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables myosin V binding	IPI IPI: Inferred from physical interaction	24006491	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17925226	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	15502842	GOA
involved in positive regulation of epithelial cell migration	IMP IMP: Inferred from mutant phenotype	22613965	GOA
involved in pseudopodium organization	IDA IDA: Inferred from direct assay	17925226	GOA
involved in regulation of vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	22613965	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	17925226	GOA
located in pseudopodium	IDA IDA: Inferred from direct assay	17925226	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB25 Protein Structure

Ras

0
100
200
213 a.a.

Protein Preferred Names

Protein Names

ras-related protein Rab-25

RAB25 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RAB25	P57735	RAB11FIP2	Homo sapiens	Q7L804	Validated Y2H	32296183
Intra	RAB25	P57735	MYO5B	Homo sapiens	Q9ULV0-2	Validated Y2H	32296183
Intra	RAB25	P57735	SH3BP5L	Homo sapiens	Q7L8J4	Y2H Prey Pooling	32296183
Intra	RAB25	P57735	SH3BP5L	Homo sapiens	Q7L8J4	Validated Y2H	32296183
Intra	RAB25	P57735	SH3BP5L	Homo sapiens	Q7L8J4	Y2H Array	32296183
Cross	RAB25	P57735	P08563-PRO_0000041303	Rubella virus	P08563-PRO_0000041303	Pull Down	24955142

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Binocular Vision Disease

Simultaneous Visual Perception Without Fusion

Corneal Dystrophy, Posterior Polymorphous, 4

PPCD4

Posterior Polymorphous Corneal Dystrophy 4

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11535	RAB25 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RAB25	VGNC	VGNC:45265
Rattus norvegicus	RAB25	RGD	RGD:1308447
Mus musculus	RAB25	MGD	MGI:1858203
Bos taurus	RAB25	VGNC	VGNC:33632
Macaca mulatta	RAB25	VGNC	VGNC:81525
Felis catus	RAB25	VGNC	VGNC:97585

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