2. Gene
  3. CD248 - CD248 molecule Gene

CD248 - CD248 molecule Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TEM1; CD164L1

Gene ID: 57124 | Gene type: protein coding

About CD248

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:66,314,494-66,317,044 (from NCBI)

This gene has 1 transcript (splice variant), 109 orthologues and 8 paralogues.

Summary

Predicted to enable extracellular matrix binding activity and extracellular matrix protein binding activity. Predicted to be involved in cell migration. Predicted to act upstream of or within several processes, including anatomical structure regression; lymph node development; and positive regulation of endothelial cell apoptotic process. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

CD248 Products(1)

mRNA Protein Name
NM_020404.3 NP_065137.1 endosialin precursor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD248 Protein Structure

Lectin_C

Lectin_C: Lectin C-type domain (42 - 157)

FXa_inhibition

FXa_inhibition: Coagulation Factor Xa inhibitory site (235 - 271)

EGF_CA

EGF_CA: Calcium-binding EGF domain (312 - 350)

  • 0
  • 200
  • 400
  • 600
  • 757 a.a.
Protein Preferred Names Protein Names

endosialin

2610111G01Rik

CD248 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CD248 Q9HCU0 LSAMP Homo sapiens Q13449
Y2H Array
32814053
Intra
CD248 Q9HCU0 LSAMP Homo sapiens Q13449
Validated Y2H
32814053
Intra
CD248 Q9HCU0 LSAMP Homo sapiens Q13449
Y2H Pooling
32814053
Intra
CD248 Q9HCU0 ICAM5 Homo sapiens Q9UMF0
Validated Y2H
32814053
Intra
CD248 Q9HCU0 ICAM5 Homo sapiens Q9UMF0
Y2H Pooling
32814053
Intra
CD248 Q9HCU0 ICAM5 Homo sapiens Q9UMF0
Y2H Array
32814053
Intra
CD248 Q9HCU0 MAPK3 Homo sapiens P27361
Y2H Pooling
32814053
Intra
CD248 Q9HCU0 MAPK3 Homo sapiens P27361
Validated Y2H
32814053
Intra
CD248 Q9HCU0 MAPK3 Homo sapiens P27361
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD248 Proteins

Cat. No. Product Name Accession Purity
HY-P78042 Endosialin/CD248 Protein, Human (HEK293, His) Q9HCU0-1 (Q18-L687) ≥95%

Related Diseases

Diseases Alias
Vascular Cancer

Blood Vessel Tumors

Malignant Vascular Neoplasm

Renal Vein Leiomyosarcoma

Vascular Neoplasms

Blood Vessel Neoplasm

Blood Vessel Tumor

Blood Vessel Tumour Disorder

Haemangiomatous Tumour

Leiomyosarcoma Of The Renal Vein

Malignant Great Vessel Tumor

Malignant Tumor Of Pulmonary Artery

Malignant Tumor Of Pulmonary Vein

Malignant Vascular Tumor

Neoplasm Of Great Vessel

Pulmonary Artery Malignant Neoplasm

Pulmonary Vein Malignant Neoplasm

Vascular Tissue Neoplasm

Vascular Tumors

Blood Vessel Cancer

Neoplasms, Vascular Tissue

Malignant Neoplasm Of Great Vessels
Granulomatous Disease, Chronic, Autosomal Recessive, 3

CGD3

Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type Iii

Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 3

Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type Iii

Cgd, Autosomal Recessive Cytochrome B-Positive, Type Iii

Granulomatous Disease, Chronic, Due To Ncf4 Deficiency

Chronic Granulomatous Disease 3, Autosomal Recessive

Autosomal Recessive Chronic Granulomatous Disease 3

Autosomal Recessive Cytochrome B-Positive Cgd Type Iii

Cdg3

Chronic Granulomatous Disease Due To Ncf4 Deficiency

Cgd Autosomal Recessive Cytochrome B-Positive Type Iii

Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type Iii

Granulomatous Disease Chronic Due To Ncf4 Deficiency

Granulomatous Disease, Chronic, Autosomal Recessive Cytochrome B-Positive, Type 3
Adult Fibrosarcoma
Urinary Tract Infection

Urinary Tract Infections

Uti

Urinary Tract Infection Nos

Uti - [Urinary Tract Infection]

Uti Nos - [Urinary Tract Infection Nos]

Urosepsis Nos

E Coli Uti

E Coli Urinary Tract Infection

Escherichia Coli Uti
Epiglottitis

Acute Epiglottitis

Acute Epiglottitis And Supraglottitis

Acute Epiglottiditis

Epiglottiditis

Epiglottitis Nos
Sarcoma

Connective And Soft Tissue Neoplasm

Tumor Of Soft Tissue And Skeleton

Sarcomas

Sarcoma - Category
Urethritis

Nonspecific Urethritis

Non-Gonococcal Urethritis

Nongonococcal Urethritis
Salmonellosis

Salmonella Infections

Salmonella Infection
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02215 CD248 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CD248 VGNC VGNC:70822
Rattus norvegicus CD248 RGD RGD:1310404
Felis catus CD248 VGNC VGNC:102744
Mus musculus CD248 MGD MGI:1917695
Bos taurus CD248 VGNC VGNC:27017
Canis familiaris CD248 VGNC VGNC:51859
Others CD248 NCBI