CD177 - CD177 molecule Gene

Homo sapiens

Also known as NB1; PRV1; HNA2A; PRV-1; HNA-2a; NB1 GP

Gene ID: 57126 | Gene type: protein coding

About CD177

Cytogenetic location: 19q13.31 Genomic coordinates (GRCh38): 19:43,353,686-43,366,081 (from NCBI)

This gene has 3 transcripts (splice variants), 97 orthologues and 2 paralogues. Biased expression in bone marrow (RPKM 83.5), colon (RPKM 72.9) and 1 other tissue.

Summary

This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified. [provided by RefSeq, Apr 2014]

CD177 Products(1)

mRNA	Protein	Name
NM_020406.4	NP_065139.2	CD177 antigen precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium-dependent protein binding	IPI IPI: Inferred from physical interaction	17580308	GOA
enables integrin binding	IPI IPI: Inferred from physical interaction	21193407	GOA
enables protease binding	IPI IPI: Inferred from physical interaction	17244676	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell adhesion	IMP IMP: Inferred from mutant phenotype	28807980	GOA
involved in cell-cell adhesion via plasma-membrane adhesion molecules	IMP IMP: Inferred from mutant phenotype	17580308	GOA
involved in cell-cell junction maintenance	IMP IMP: Inferred from mutant phenotype	23202369	GOA
involved in leukocyte cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	17580308	GOA
involved in neutrophil extravasation	IMP IMP: Inferred from mutant phenotype	17580308	GOA
NOT involved in neutrophil migration	IMP IMP: Inferred from mutant phenotype	28240246	GOA
involved in neutrophil migration	IMP IMP: Inferred from mutant phenotype	28807980	GOA
involved in positive regulation of neutrophil degranulation	IGI IGI: Inferred from genetic interaction	21193407	GOA
involved in positive regulation of superoxide anion generation	IGI IGI: Inferred from genetic interaction	21193407	GOA
involved in protein localization to cell surface	IMP IMP: Inferred from mutant phenotype	17244676	GOA
involved in regulation of endocytosis	IDA IDA: Inferred from direct assay	28807980	GOA
involved in regulation of integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	28807980	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	12675722	GOA
located in plasma membrane raft	IDA IDA: Inferred from direct assay	21193407	GOA
located in secretory granule membrane	IDA IDA: Inferred from direct assay	18462208	GOA
located in tertiary granule membrane	IDA IDA: Inferred from direct assay	18462208	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

CD177 antigen

NB1 glycoprotein

CD177 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CD177	Q8N6Q3	KCNIP3	Homo sapiens	Q9Y2W7	Validated Y2H	32296183
Intra	CD177	Q8N6Q3	KCNIP3	Homo sapiens	Q9Y2W7	Y2H Prey Pooling	32296183
Intra	CD177	Q8N6Q3	KCNIP3	Homo sapiens	Q9Y2W7	Y2H Array	25416956
Intra	CD177	Q8N6Q3	KCNIP3	Homo sapiens	Q9Y2W7	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD177 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7801	CD177 Protein, Human (HEK293, His)	AAH29167.1 (L22-G407)	≥95%

Related Diseases

Diseases

Alias

Polycythemia

Erythrocythemia	Polycythemia Vera
Polycythaemia Due To High Altitude

Polycythemia Vera

PV	Polycythemia Rubra Vera
Prv	Osler-Vaquez Disease
Chronic Erythremia	Polycythaemia Rubra Vera
Primary Polycythemia	Vaquez Disease
Polycythemia Vera, Somatic	Osler-Vaquez Syndrome
Proliferative Polycythaemia	Polycythemia Ruba Vera
Acquired Primary Erythrocytosis	Heilmeyer-Schoner Disease
Vaquez Osler Disease	Primary Polycythaemia

Essential Thrombocythemia

Essential Thrombocytosis	Familial Thrombocytosis
Hemorrhagic Thrombocythemia	Hereditary Thrombocythemia
Primary Thrombocytosis	Idiopathic Thrombocythemia
Primary Thrombocythemia	Thrombocythemia, Essential
Essential Thrombocythaemia	Et
Familial Thrombocythemia	Thrombocythemia Essential

Myelofibrosis

Primary Myelofibrosis	Agnogenic Myeloid Metaplasia
Idiopathic Myelofibrosis	Myeloid Metaplasia
Myelofibrosis With Myeloid Metaplasia	Osteomyelofibrosis
Megakaryocytic Myelosclerosis	Myelosclerosis
Chronic Idiopathic Myelofibrosis	Myelofibrosis, Idiopathic
Myelofibrosis With Myeloid Metaplasia, Somatic	Myelofibrosis, Somatic
Aleukemic Myelosis	Bone Marrow Fibrosis
MYELOF	MMM
Agnogenic Myeloid Metaplasia With Myelofibrosis	Ammm
Myelosclerosis With Myeloid Metaplasia	Myelofibrosis Nos

Deep Leiomyoma

Myeloproliferative Neoplasm

Myeloproliferative Disorder	Chronic Myeloproliferative Disease
Myeloproliferative Neoplasms	Chronic Myeloproliferative Disorder
Cmpd	Cmpd, U
Chronic Myeloproliferative Disorders	Mpd
Mpn	Myeloproliferative Disorders
Myeloproliferative Disease	Campomelic Dysplasia

Neutropenia

Leukopenia

Thrombocytosis

Thrombocythaemia

Myopathy, Centronuclear, 1

Autosomal Dominant Centronuclear Myopathy	CNM1
Centronuclear Myopathy 1	Ad-Cnm
Myopathy, Centronuclear, Autosomal Dominant	Myotubular Myopathy, Autosomal Dominant
Centronuclear Myopathy, Autosomal, Modifier Of	Autosomal Dominant Myotubular Myopathy
Dnm2-Related Centronuclear Myopathy	Centronuclear Myopathy Autosomal Dominant
Myopathies, Structural, Congenital	Myopathy, Centronuclear, Type 1

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia	Chronic Myelogenous Leukemia
CML	Chronic Granulocytic Leukemia
Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib	Chronic Myeloid Leukaemia
Chronic Granulocytic Leukaemia	Chronic Myelogenous Leukaemia
Myeloid Leukemia, Chronic	Leukemia, Chronic Myelogenous
Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic	Cml - Chronic Myelogenous Leukemia
Cgl	Chronic Myelocytic Leukemia
Leukemia, Chronic Myeloid, Atypical	ACML
Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative	Myeloid Leukemia Chronic
Leukemia, Myeloid, Chronic	Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative
Cml- [Chronic Myeloid Leukaemia]	Cgl - [Chronic Granulocytic Leukaemia]
Chronic Myelocytic Leukaemia

Adult Hepatocellular Carcinoma

Adult Primary Hepatocellular Carcinoma	Adult Hepatoma
Adult Hcc

Myelodysplastic Syndrome

Myelodysplastic Syndromes	Myelodysplasia
MDS	Myelodysplastic Syndrome Included
Myelodysplastic Syndrome, Susceptibility To, Included	Myelodysplastic Syndrome, Somatic
Myelodysplastic Syndrome, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02196	CD177 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-E70527	Proteinase 3 (PR3), Human Neutrophil		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CD177	RGD	RGD:1562941
Macaca mulatta	CD177	VGNC	VGNC:70912
Mus musculus	CD177	MGD	MGI:1916141
Canis familiaris	CD177	VGNC	VGNC:38934
Bos taurus	CD177	VGNC	VGNC:27006
Others	CD177	NCBI

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